Skip to main content
SpringerLink
Log in

Pharmacokinetics of caffeine in patients with decompensated type I and type II diabetes mellitus

  • Originals
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

Diabetes may alter the pharmacokinetics of aminopyrine and antipyrine, which are used to assess liver function. Caffeine has recently been used to test liver function, but the effect of diabetes on caffeine kinetics is not known.

The kinetics of caffeine has been examined in patients with decompensated Type I and Type II diabetes and in two age- and sex-matched control groups. In both types of diabetes the apparent caffeine clearance, half-life, and apparent volume of distribution were similar to controls.

It is concluded that decompensated diabetes does not influence the cytochrome P-448 mono-oxygenase system responsible for caffeine metabolism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Faas FH, Carter WJ (1980) Cytochrome P-450 mediated drug metabolism in the streptozotocin diabetic rat. Horm Metabol Res 12: 706–707

    Google Scholar 

  2. Daintith H, Stevenson IH, O'Malley KO (1976) Influence of diabetes mellitus on drug metabolism in man. Int J Clin Pharmacol 13: 55–58

    Google Scholar 

  3. Reinke LA, Stohs SJ, Rosenberg H (1978) Altered activity of hepatic mixed-function mono-oxygenase enzymes in streptozotocin-induced diabetic rats. Xenobiotica 8: 611–619

    Google Scholar 

  4. Zysset T, Sommer L (1986) Diabetes alters drug metabolism — in vivo studies in a streptozotocin-diabetic rat model. Experientia 42: 560–562

    Google Scholar 

  5. Zysset T, Tlach C (1987) Altered liver function in diabetes: Model experiments with aminopyrine in the rat. J Pharmacol Exp Ther 240: 271–276

    Google Scholar 

  6. Zysset T, Wietholtz H (1988) Differential effect of Type I and Type II diabetes on antipyrine disposition in man. Eur J Clin Pharmacol 34: 369–375

    Google Scholar 

  7. Past MR, Cook DE (1982) Effect of diabetes on rat liver cytochrome P-450. Evidence for a unique diabetes-dependent rat liver cytochrome P-450. Biochem Pharmacol 31: 3329–3334

    Google Scholar 

  8. Bircher J, Küpfer A, Gikalov I, Preisig R (1976) Dose dependence of the14C-aminopyrine breath test. Clin Pharmacol Ther 20: 484–492

    Google Scholar 

  9. Hepner GW, Vesell ES (1974) Assessment of aminopyrine metabolism in man by breath analysis after oral administration of14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis. N Engl J Med 291: 1384–1388

    Google Scholar 

  10. Saunders JB, Lewis KO, Paton A (1980) Early diagnosis of alcoholic cirrhosis by the aminopyrine breath test. Gastroenterology 79: 112–114

    Google Scholar 

  11. Andreasen PB, Greisen G (1976) Phenazone metabolism in patients with liver disease. Eur J Clin Invest 6: 21–26

    Google Scholar 

  12. Vestal RE, Norris AH, Tobin JD, Cohen BJH, Shock NW, Andres R (1975) Antipyrine metabolism in man: influence of age, alcohol, caffeine, and smoking. Clin Pharmacol Ther 18: 425–432

    Google Scholar 

  13. Teunissen MWE, Spoelstra P, Koch CW, Weeda B, Van Duyn W, Janssens AR, Breimer DD (1984) Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis. Br J Clin Pharmacol 18: 707–715

    Google Scholar 

  14. Vesell ES (1979) The antipyrine test in clinical pharmacology: conceptions and misconceptions. Clin Pharmacol Ther 26: 275–286

    Google Scholar 

  15. Jost G, Wahlländer A, von Mandach U, Preisig R (1987) Overnight salivary caffeine clearance: a liver function test suitable for routine use. Hepatology 7: 338–344

    Google Scholar 

  16. Renner E, Wietholtz H, Huguenin P, Arnaud MJ, Preisig R (1984) Caffeine: a model compound for measuring liver function. Hepatology 1: 38–46

    Google Scholar 

  17. Wahlländer A, Renner E, Preisig R (1985) Fasting plasma caffeine concentration. A guide to severity of chronic liver disease. Scand J Gastroenterol 20: 1133–1141

    Google Scholar 

  18. Wietholtz H, Vögelin M, Arnaud MJ, Bircher J, Preisig R (1981) Assessment of the cytochrome P-448 dependent liver enzyme system by a caffeine breath test. Eur J Clin Pharmacol 21: 53–59

    Google Scholar 

  19. Perucca E, Hedges A, Makki KA, Ruprah M, Wilson JF, Richens A (1984) A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. Br J Clin Pharmacol 18: 401–410

    Google Scholar 

  20. Melani F, Rubenstein AH, Oyer PE, Steiner DF (1970) Identification of proinsulin and C-peptide in human serum by a specific immunoassay. Proc Natl Acad Sci USA 67: 541

    Google Scholar 

  21. Zysset T, Wahlländer A, Preisig R (1984) Evaluation of caffeine plasma levels by an automated enzyme immunoassay (EMIT) in comparison with a high-performance liquid chromatographic method. Ther Drug Monit 6: 348–354

    Google Scholar 

  22. Bonati M, Latini R, Galletti F, Young JF, Tognoni G, Garattini S (1982) Caffeine disposition after oral doses. Clin Pharmacol Ther 32: 98–106

    Google Scholar 

  23. Wissenschaftliche Tabellen Geigy (1980) Teilband Statistik, 8. Auflage, Ciba-Geigy Ldt. Basle, Switzerland

    Google Scholar 

  24. Welborn TA, Garcia-Webb P, Bonser AM (1981) Basal C-peptide in the discrimination of type I from Type II diabetes. Diabetes Care 4: 616–619

    Google Scholar 

  25. Desmond P, Patwardhan RH, Johnson RF, Schenker S (1980) Impaired elimination of caffeine in cirrhosis. Dig Dis Sci 25: 193–197

    Google Scholar 

  26. Parsons WD, Neims AH (1978) Effect of smoking on caffeine clearance. Clin Pharmacol Ther 24: 40–45

    Google Scholar 

  27. Schnegg M, Lauterburg BH (1986) Quantitative liver function in the elderly assessed by galactose elimination capacity, aminopyrine demethylation and caffeine clearance. J Hepatol 3: 164–171

    Google Scholar 

  28. Wietholtz H, Zysset Th, Kreiten K, Kohl D, Büchsel R, Matern S (1989) Effect of phenytoin carbamazepine and valproic acid on caffeine metabolism. Eur J Clin Pharmacol 36: 401–406

    Google Scholar 

  29. Camilleri M, Malagelada JR (1984) Abnormal intestinal motility in diabetics with the gastroparesis syndrome. Eur J Invest 14: 420–427

    Google Scholar 

  30. Saltzman MB, McCallum RW (1983) Diabetes and the stomach. Yale J Biol Med 56: 179–187

    Google Scholar 

  31. Nakanome C, Akai H, Hongo M, Imai N, Toyota T, Goto Y, Okuguchi F, Komatsu K (1983) Disturbances of the alimentary tract motility and hypermotilinemia in the patients with diabetes mellitus. Tohoku J Exp Med 139: 205–215

    Google Scholar 

  32. Murali KV, Adithan C, Shashindran CH, Gambhir SS, Chandrasekar S (1983) Antipyrine metabolism in patients with diabetes mellitus. Clin Exp Pharmacol Physiol 10: 7–13

    Google Scholar 

  33. Campbell ME, Grant DM, Inaba T, Kalow W (1987) Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes. Drug Metab Dispos 15: 237–249

    Google Scholar 

  34. Nebert DW, Negishi M (1982) Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution. Biochem Pharmacol 31: 2311–2317

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, Regionalspital Biel, Biel, Switzerland

    T. Zysset

  2. Department of Internal Medicine, Neues Klinikum, Aachen, FRG

    H. Wietholtz

Authors
  1. T. Zysset
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Wietholtz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zysset, T., Wietholtz, H. Pharmacokinetics of caffeine in patients with decompensated type I and type II diabetes mellitus. Eur J Clin Pharmacol 41, 449–452 (1991). https://doi.org/10.1007/BF00626367

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00626367

Key words

Search

Navigation