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Microbiological transformation of cannabinoids

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Summary

Microorganisms were screened for their ability to modify 2 synthetic cannabinoid substrates (I andII). Structure analyses revealed that microorganisms transformed the substrates by (a) primary oxidation of the side chain, β-oxidation of the side chain, ketone formation on the side chain or cyclohexene ring, (b) secondary hydroxylation on the side chain, (c) aromatization of the cyclohexene ring, and (d) tertiary hydroxylation at the b/c ring juncture.

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Authors and Affiliations

  1. The Lilly Research Laboratories, Eli Lilly and Company, 46206, Indianapolis, Indiana, USA

    B. J. Abbott, D. S. Fukuda & R. A. Archer

Authors
  1. B. J. Abbott
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  2. D. S. Fukuda
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  3. R. A. Archer
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Abbott, B.J., Fukuda, D.S. & Archer, R.A. Microbiological transformation of cannabinoids. Experientia 33, 718–720 (1977). https://doi.org/10.1007/BF01944147

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  • DOI: https://doi.org/10.1007/BF01944147

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