Fraunhofer-Publica

The Fraunhofer-Publica has been successfully documenting the research results of the Fraunhofer-Gesellschaft for over 30 years. The platform enables the collaborative linking of research-relevant objects and disseminates within the international scientific community.

The Fraunhofer-Publica thus fulfils its responsibility to promote the transfer of knowledge and know-how to industry and society.

Categories

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Research outputs

As an application-oriented research organisation, Fraunhofer aims to conduct highly innovative and solution-oriented research - for the benefit of society and to strengthen the German and European economy.

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Projects

Fraunhofer is tackling the current challenges facing industry head on. By pooling their expertise and involving industrial partners at an early stage, the Fraunhofer Institutes involved in the projects aim to turn original scientific ideas into marketable products as quickly as possible.

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Researchers

Scientific achievement and practical relevance are not opposites - at Fraunhofer they are mutually dependent. Thanks to the close organisational links between Fraunhofer Institutes and universities, science at Fraunhofer is conducted at an internationally first-class level.

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Institutes

The Fraunhofer-Gesellschaft is the leading organisation for applied research in Europe. Institutes and research facilities work under its umbrella at various locations throughout Germany.

Recent Additions

  • Publication
    Alternative strategies for the recombinant synthesis, DOPA modification and analysis of mussel foot proteins - A case study for Mefp-3 from Mytilus edulis
    ( 2024)
    Zwies, Constanze
    ;
    Rodríguez, Ángela María Vargas
    ;
    Naumann, Marcel
    ;
    Seifert, Franziska
    ;
    Pietzsch, Markus
    Mussel foot proteins (Mfps) possess unique binding properties to various surfaces due to the presence of L-3,4-dihydroxyphenylalanine (DOPA). Mytilus edulis foot protein-3 (Mefp-3) is one of several proteins in the byssal adhesive plaque. Its localization at the plaque-substrate interface approved that Mefp-3 plays a key role in adhesion. Therefore, the protein is suitable for the development of innovative bio-based binders. However, recombinant Mfp-3s are mainly purified from inclusion bodies under denaturing conditions. Here, we describe a robust and reproducible protocol for obtaining soluble and tag-free Mefp-3 using the SUMO-fusion technology. Additionally, a microbial tyrosinase from Verrucomicrobium spinosum was used for the in vitro hydroxylation of peptide-bound tyrosines in Mefp-3 for the first time. The highly hydroxylated Mefp-3, confirmed by MALDI-TOF-MS, exhibited excellent adhesive properties comparable to a commercial glue. These results demonstrate a concerted and simplified high yield production process for recombinant soluble and tag-free Mfp3-based proteins with on demand DOPA modification.
  • Publication
    Keynote: 4-D+ nanoSCOPE Project
    ( 2024)
    Christiansen, Silke
    The number of elderly and very elderly people is increasing worldwide, and so is the number of patients suffering from osteoporosis. This disease significantly impairs the quality of life and leads to high social costs. Nevertheless, the origin and course of osteoporosis are still not sufficiently understood. This is because methods for an in-depth analysis of the fine bone structure over time in living individuals are not yet available, especially those that also allow large matrix studies with statistical significance. An interdisciplinary research project now wants to change this. The 4-D+ nanoSCOPE project is developing a groundbreaking X-ray microscope (image acquisition with submicron resolution over a hundred times faster than is currently possible). An interdisciplinary team intend to enable X-ray microscopy studies in living creatures for the very first time. They plan to do so by combining state-of-the-art imaging techniques with innovative precision learning software and a novel Xray microscope. Their method has the potential to revolutionize our understanding of bone structure and improve bone remodelling, by enabling an effective assessment of the effects on bone of age, hormones, inflammation and treatment.
  • Mainwork
    Bildverarbeitung für die Medizin 2024
    (Springer Vieweg, 2024)
    Maier, Andreas

Most viewed

  • Publication
    Tailoring the MontiArcAutomaton Component & Connector ADL for Generative Development
    ( 2015)
    Ringert, J.O.
    ;
    Rumpe, B.
    ;
    Wortmann, A.
    Component & connector (C&C) architecture description languages (ADLs) combine component-based software engineering and model-driven engineering to increase reuse and to abstract from implementation details. Applied to robotics application development, current C&C ADLs often require domain experts to provide component behavior descriptions as programming language artifacts or as models of a-priori fixed behavior modeling languages. They are limited to specific target platforms or require extensive handcrafting to transform platform-independent software architecture models into platform-specific implementations. We have developed the MontiArcAutomaton framework that combines structural extension of C&C concepts with integration of application-specific component behavior modeling languages, seamless transformation from logical into platform-specific software architectures, and a-posteriori black-box composition of code generators for different robotics platforms. This paper describes the roles and activities for tailoring MontiArcAutomaton to application-specific demands.