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Nano-machining of biosensor electrodes through gold nanoparticles deposition produced by femtosecond laser ablation

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Abstract

We report an application of femtosecond laser ablation to improve the sensitivity of biosensors based on a quartz crystal microbalance device. The nanoparticles produced by irradiating a gold target with 527-nm, 300-fs laser pulses, in high vacuum, are directly deposited on the quartz crystal microbalance electrode. Different gold electrodes are fabricated by varying the deposition time, thus addressing how the nanoparticles surface coverage influences the sensor response. The modified biosensor is tested by weighting immobilized IgG antibody from goat and its analyte (IgG from mouse), and the results are compared with a standard electrode. A substantial increase of biosensor sensitivity is achieved, thus demonstrating that femtosecond laser ablation and deposition is a viable physical method to improve the biosensor sensitivity by means of nanostructured electrodes.

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Acknowledgments

We acknowledge the financial support of the Fondazione con il Sud (Project No. 2011-PDR-18, “Biosensori piezoelettrici a risposta in tempo reale per applicazioni ambientali e agro-alimentari”).

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Authors and Affiliations

  1. Dipartimento di Fisica, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia, 80126, Naples, Italy

    B. Della Ventura, R. Funari, K. K. Anoop, S. Amoruso, G. Ausanio, F. Gesuele, R. Velotta & C. Altucci

  2. CNR-SPIN, UOS Napoli Complesso Universitario di Monte S. Angelo, Via Cintia, 80126, Naples, Italy

    K. K. Anoop, S. Amoruso & G. Ausanio

Authors
  1. B. Della Ventura
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  2. R. Funari
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  3. K. K. Anoop
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  4. S. Amoruso
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  5. G. Ausanio
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  6. F. Gesuele
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  7. R. Velotta
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  8. C. Altucci
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Correspondence to S. Amoruso.

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Della Ventura, B., Funari, R., Anoop, K.K. et al. Nano-machining of biosensor electrodes through gold nanoparticles deposition produced by femtosecond laser ablation. Appl. Phys. B 119, 497–501 (2015). https://doi.org/10.1007/s00340-015-6091-3

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  • DOI: https://doi.org/10.1007/s00340-015-6091-3

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