The elasto-optic properties of liquids on the basis of the first principles of acousto-optics were theoretically investigated. A relationship for calculating the elasto-optic constant of liquids using only the refractive index was obtained. The refractive index values corresponding to the maximum elasto-optic constant for polar and nonpolar liquids were determined. Calculations for about 100 liquids were performed and compared with known experimental data. This study significantly extends our understanding of the acousto-optic effect and has practical applications for predicting the elasto-optic constant of a liquid and estimating its wavelength dispersion. Full article

In this study, the development trends of bioclimatic parameters recorded at the Maribor and Murska Sobota climate stations from 1952 to 2022 and the dynamics of grape ripening in early-, medium-, and late-ripening grape varieties in the Podravje wine-growing region in Slovenia (north-eastern Slovenia) from 1980 to 2022 were investigated. Based on the data on soluble solids content, total acidity, and the recommended harvest date per year (until the technological ripeness of the grapes; 76°Oe), trends for shortening the growing period of the vines were calculated. Temperature changes have been more pronounced since 1980. The number of so-called hot days (with a maximum of T > 30 °C) has increased the most, which has the greatest impact on other bioclimatic parameters, e.g., the average temperature and growing degree days (GDDs) and the Huglin index (HI). For the period of 1980 to 2022, the trends were 0.44 °C (Murska Sobota) and 0.51 °C (Maribor) per decade, respectively. The trends were more pronounced for the average temperature in the period of May–June (TMJ). After 1980, the HI increased by about 10 units per year. As a result of the climate warming, grapes in north-eastern Slovenia ripened 26 (‘Sauvignon Blanc’) to 35 (‘Welschriesling’) days earlier. The trends showed a decrease in total acidity, which can be attributed to the higher temperatures during the growing season period, especially during the ripening period of the grapes (véraison). After 2010, the average temperatures during the growing season (1 April to 31 October) in Podravje were 1.6 °C higher than in the 1980s. In line with the earlier ripening of the grapes, the actual average temperature from 1 April to the harvest date was a further 1.0 °C higher. The higher temperatures in the late-ripening varieties ‘Riesling’ and ‘Furmint’ had a positive effect on the lower total acidity. Total annual precipitation and precipitation in the growing season for the period 1980 to 2022 in the Maribor area show decreasing trends of 6 mm/m² (p = 0.001) and 4 mm/m² (p = 0.012), respectively. In the eastern sub-wine-growing region of Podravje (Murska Sobota), the trends in precipitation were not significant. Full article

This article presents two monopole antennas with an endfire radiation pattern in the UHF band that can be installed on dry walls or metallic cabinets as a part of wireless sensor nodes, making them a suitable choice for smart home applications, such as the wireless remote control of house appliances. Two different antennas are proposed to cover the RFID bands of North America (902–928 MHz) and worldwide (860–960 MHz). The antennas have wide horizontal radiation patterns that provide great reading coverage in their communication with a base station placed at a certain distance from the antennas. The structures have two ground planes, one in-plane and the other vertical. The vertical ground helps the antenna to have a directive radiation and also makes it easily installed on walls. The antenna feeding line lies over the vertical ground substrate. The maximum dimensions of the narrow-band antenna are L × W = 0.3$\lambda \times$ 0.14$\lambda$, and those for the wide-band antenna are L × W = 0.39$\lambda \times$ 0.14$\lambda$. The measured results show that the bandwidth of the proposed antennas for the North America and worldwide RFID bands are from 902 MHz to 939 MHz and 822 MHz to 961 MHz, with maximum gains of 4.2 dBi and 4.9 dBi, respectively. Full article

Wind turbines emit infrasound and low-frequency noise (ILFN), which can be annoying for people living near wind farms. To assess the acoustic impact of wind turbines on the environment, it is essential to model ILFN propagation during the forecasting stage. This study assesses the effectiveness of three commonly used sound propagation models (ISO 9613-2, CNOSSOS-EU for favourable propagation conditions, Nord2000) in predicting ILFN generated by wind turbines. The performance of these models in modelling ILFN is generally not validated or guaranteed. The analysis covers octave frequency bands ranging from 4 Hz to 250 Hz, and comparisons are made against measurements conducted at a wind farm in Poland. Non-parametric statistical tests were used with a significance level of $\alpha =0.05$ to determine significant differences between measured and predicted results. The results show that the Nord2000 method provides accurate calculations, while the ISO 9613-2 method can be used for simplified assessments of ILFN generated by wind turbines during the investment preparation phase. Full article

Optical tracking of head pose via fiducial markers has been proven to enable effective correction of motion artifacts in the brain during magnetic resonance imaging but remains difficult to implement in the clinic due to lengthy calibration and set up times. Advances in deep learning for markerless head pose estimation have yet to be applied to this problem because of the sub-millimetre spatial resolution required for motion correction. In the present work, two optical tracking systems are described for the development and training of a neural network: one marker-based system (a testing platform for measuring ground truth head pose) with high tracking fidelity to act as the training labels, and one markerless deep-learning-based system using images of the markerless head as input to the network. The markerless system has the potential to overcome issues of marker occlusion, insufficient rigid attachment of the marker, lengthy calibration times, and unequal performance across degrees of freedom (DOF), all of which hamper the adoption of marker-based solutions in the clinic. Detail is provided on the development of a custom moiré-enhanced fiducial marker for use as ground truth and on the calibration procedure for both optical tracking systems. Additionally, the development of a synthetic head pose dataset is described for the proof of concept and initial pre-training of a simple convolutional neural network. Results indicate that the ground truth system has been sufficiently calibrated and can track head pose with an error of <1 mm and <1°. Tracking data of a healthy, adult participant are shown. Pre-training results show that the average root-mean-squared error across the 6 DOF is 0.13 and 0.36 (mm or degrees) on a head model included and excluded from the training dataset, respectively. Overall, this work indicates excellent feasibility of the deep-learning-based approach and will enable future work in training and testing on a real dataset in the MRI environment. Full article

Rickettsioses, often underreported, pose public health challenges. Rickettsia asembonensis is a potential emerging pathogen that was previously detected in humans, animals, and a variety of arthropods. While its pathogenicity in humans remains unclear, it poses a potential public health threat. Here, we present an extended epidemiological, diagnostic, and genetic analysis of the information provided in a preliminary report on the investigation of rickettsiae in Peru. In particular, we report the detection of R. asembonensis in blood specimens collected from four human patients with an acute undifferentiated fever of a seven- to nine-day duration, all of whom tested negative for other vector-borne pathogens. Additionally, we describe the replicative capacity of the R. asembonensis isolates in cell cultures. Full article

Background: Vulvar stenosis is a debilitating condition that compromises sexual function, urination, and the ability to undergo gynecological examinations. The purpose of this study is to describe the technique of capillary perforator perineal flaps (CPPF) for the correction of vulvar stenosis. Methods: We retrospectively examined patients with vulvar stenosis treated through surgical separation and reconstruction with CPPF. The procedure involved vulvar separation with the creation of a subsequent defect, repaired using a flap, harvested laterally to the labia majora including a capillary perforator and transferred through a subcutaneous tunnel to repair the vulvar defect. The functional outcome was evaluated with the Bradford scale, comparing the preoperative and postoperative scores using the Student’s t-test. Results: thirteen patients were included, three with stenosis following treatment for vulvar cancer and ten due to lichen sclerosus. In total, we analyzed 29 flaps, with an average size of 15.6 cm². We always included just one perforator in the flap and no postoperative complications. Stenosis was resolved in all patients, with no recurrences one year after the surgery. The preoperative average severity of the stenosis was 2.3 + 0.6, reducing to 0.3 + 0.4 post-intervention, indicating a significant improvement (p < 0.01). Conclusions: CPPF has proven to be a quick and safe method for the reconstruction of vulvar stenosis. Full article

The effect of bacterial cellulose nanocrystal–fish gelatin/cinnamon essential oil (BCNCs–FGelA/CEO) nanocoatings containing different concentrations of essential oil (1.2, 1.8, and 2.4 mL/L) on reducing the ripening and aging processes of ‘Red Gold’ nectarine fruit during cold storage (60 days, 4 °C) was studied. As a general trend, the application of the coating delayed the ripening process, and increasing the concentration of essential oil was effective in improving the coating efficacy. After 60 days, the lowest values of weight loss (6.93%), peroxidase and polyphenol oxidase activity (11.49 and 0.48 abs min⁻¹ g⁻¹, respectively), soluble solid content (14.56%), and pH (4.17) were detected for samples covered with the BCNCs–FGelA coatings containing the highest tested CEO concentration, whereas the maximum values of the same parameters (20.68%, 18.74 and 0.76 abs min⁻¹ g⁻¹, 17.93%, and 4.39, respectively) were found in the uncoated samples. In addition, increasing the concentration of the essential oil resulted in a better preservation of the firmness, ascorbic acid, and total acidity of the samples. Finally, the respiration rate and ethylene production of coated samples were lower than those detected in uncoated samples, though some differences arose depending on the amount of CEO loaded in the coatings. This study showed the capability of BCNCs–FGelA/CEO coatings to increase the cold storage period and preserve the quality of ‘Red Gold’ nectarine fruit, thereby reducing losses and increasing economic efficiency in the fruit industry. Full article

The aging process of wine is influenced by various factors, including the presence of oxygen, the temperature, and the storage conditions. While oxygen can have both positive and negative effects on wine quality, temperature fluctuations during storage can impact its chemical composition. This study has investigated the aging of Merlot and Sangiovese wines under traditional cellar conditions and underwater, exploring the influence of storage parameters on their chemical evolution. Analyzing parameters such as temperature, pressure, and chemical composition, the research revealed subtle but significant changes in the wines over time. Both wines showed a gradual reduction in total phenols, anthocyanins, non-flavonoid compounds, and total sulfur dioxide, irrespective of the storage conditions. Preliminary findings suggested that aging wine underwater does not induce significant alterations in its fundamental characteristics compared to traditional cellar aging. These results contribute to a deeper understanding of wine aging processes and highlight the importance of storage conditions in preserving wine quality. Further research is needed to fully elucidate the complexities of underwater aging and its broader implications for wine production. Full article

Species belonging to the genus Echinophora (Apiaceae) have been used by humanity since ancient times as flavoring agents, preservatives, and medicines for the treatment of a broad spectrum of conditions, including respiratory, digestive and kidney disorders, fungi infections, wounds, and gastric ulcers. Phytochemical studies on this botanical genus mainly investigate the essential oil composition and reveal the species as a rich source of volatile compounds, including monoterpenes and phenylpropanoids. Among the non-volatile secondary metabolites, flavonoids, coumarins, phenolic acids, phytosterols, and polyacetylenes have been identified. Pharmacological studies revealed Echinophora extracts and essential oils exhibit different biological properties, including antibacterial, antifungal, anticancer, insecticidal, anti-inflammatory, and hepatoprotective activities. However, compared to other genera, the biological activity and chemical diversity of this genus are not well studied. In future decades, it is highly likely that the small genus Echinophora will play an important role in drug discovery and drug development. Full article

Although American Indian and Alaska Native (AIAN) students are the most underrepresented group in the U.S. in biomedical and health sciences relative to population size, little is known about long-term research education programs and outcome tracking. For over 20 years, the Partnership for Native American Cancer Prevention (NACP) has been supported under the National Cancer Institute’s (NCI)-funded Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) program. Programming included hands-on mentored research and an array of development opportunities. A validated tracking system combining participation records, institutional records, and enrollment/degree attainment from the National Student Clearinghouse documents outcomes. Collectively (2002–2022) NACP engaged 367 AIAN trainees, of whom 237 individuals earned 220 bachelors, 87 masters, and 34 doctoral/professional degrees. Approximately 45% of AIAN doctoral recipients are currently engaged in academic or clinical work, and 10% in industry or tribal leadership. A total of 238 AIAN students participated in mentored research, with 85% demonstrating strong outcomes; 51% attained a degree, and 34% are currently enrolled. Implementation of a robust tracking system documented acceleration in degree attainment over time. Next steps will evaluate the most impactful training activities on student outcomes. Full article

Background: The group climate within residential youth care institutions is considered a transactional process, both within a group of youth from various cultural backgrounds and between them and their group workers. The ongoing interaction between the cultural characteristics of these girls may influence the quality of the group climate. This study aimed to provide an in-depth account of the living group climate experiences and perceptions of Dutch girls with a Moroccan cultural background in Dutch residential groups. Method: Interpretative phenomenological analysis was employed to explore the girls’ group climate experiences. Result: Three major themes emerged, namely (a) level of involvement of Moroccan girls in their living group, (b) perceptions of Moroccan girls’ sense of belonging in a living group, and (c) cultural and religious equality or disparity results in two interaction patterns. The findings revealed that equality or disparity in language, culture, and religion affect Moroccan girls’ experiences and perceptions of the living group climate. A crucial finding was that cultural and religious disparity leads to interaction patterns wherein the girls pre-emptively exclude themselves from receiving support from native group workers. Conclusion: Professionals must be aware of the cultural and religious dynamics, including the interplay and impact of cultural and religious equality and disparity, influencing Moroccan girls’ group climate experiences. Full article

Background: Modulator therapies improve weight and body mass index (BMI) in cystic fibrosis (CF) patients. We aimed to compare the nutritional risk index (NRI) in adult CF patients receiving modulator (MT) or only non-modulator (conventional) therapies (non-MT). Methods: A single-center prospective cohort study was conducted between June and December 2023. The NRI based on weight gain and albumin was calculated at beginning and end of a 12-week period in both groups. This design was pragmatic, since it was based on individual patient access to MT for 12 weeks. Results: In total, 107 patients were included [mean (SD) age: 23.85 (4.98) years, 54.7% male, 46.7% MT]. In the MT group, mean (SD) weight (kg) and albumin (g/dL) increased significantly [changes: +3.09 (2.74) and +0.17 (0.37); p < 0.001]. In the non-MT group, weight and albumin decreased significantly [changes: −0.99 (1.73) and −0.12 (0.30); p < 0.001]. Compared to the MT group, baseline mean (SD) NRI in the non-MT group was significantly higher [100.65 (11.80) vs. 104.10 (10.10); p = 0.044]. At the end of the 12 weeks, mean (SD) NRI in the MT group was higher than in the non-MT group [104.18 (10.40) vs. 102.58 (12.39); p = 0.145]. In the MT group, the NRI category improved in 22 (44%), and worsened in 3 (6%) patients (p < 0.001). In the non-MT group, the NRI category improved in 2 (3.5%), and worsened in 10 (17.5%) patients (p < 0.001). Conclusions: This is the first study reporting on a positive effect of MT on NRIs, based on weight gain and albumin. Personalized nutrition and routine follow-up of adults with CF based on NRI is recommended prior to MT initiation. Full article

To ensure the safety of vehicle travel, the maintenance of road infrastructure has become increasingly critical, with efficient and accurate detection techniques for road cracks emerging as a key research focus in the industry. The development of deep learning technologies has shown tremendous potential in improving the efficiency of road crack detection. While convolutional neural networks have proven effective in most semantic segmentation tasks, overcoming their limitations in road crack segmentation remains a challenge. To address this, this paper proposes a novel road crack segmentation network that leverages the powerful spatial feature modeling capabilities of Swin Transformer and the Encoder–Decoder architecture of DeepLabv3+. Additionally, the incorporation of a multi-scale coding module and attention mechanism enhances the network’s ability to densely fuse multi-scale features and expand the receptive field, thereby improving the integration of information from feature maps. Performance comparisons with current mainstream semantic segmentation models on crack datasets demonstrate that the proposed model achieves the best results, with an MIoU of 81.06%, Precision of 79.95%, and F1-score of 77.56%. The experimental results further highlight the model’s superior ability in identifying complex and irregular cracks and extracting contours, providing guidance for future applications in this field. Full article

Loose-fill thermal composite insulation produced from surface-modified wood scobs has been explored as a potential fire-resistant material for building envelopes. This work involves fire resistance behavior comparisons between four coating systems consisting of liquid glass, liquid glass-tung oil, liquid glass-expandable graphite, and liquid glass-tung oil-expandable graphite. The techniques of thermogravimetric and differential thermogravimetric analyses, gross heat combustion via a calorimetric bomb, cone calorimetry, SEM imaging of char residues, and energy dispersive spectrometry for elemental analysis, as well as propensity to undergo continuous smoldering, were implemented. The coating technique resulted in greater thermal stability at a higher temperature range (500–650 °C) of the resulting loose-fill thermal composite insulation, reduced flame-damaged area heights after the exposure of samples at 45° for 15 s and 30 s, with a maximum of 49% decreased gross heat combustion, reduced heat release and total smoke release rates, improved char residue layer formation during combustion and changed smoldering behavior due to the formation of homogeneous and dense carbon layers. The results showed that the highest positive impact was obtained using the liquid glass and liquid glass-expandable graphite system because of the ability of the liquid glass to cover the wood scob particle surface and form a stable and strong expanding carbon layer. Full article

ZF-HD transcription factors, which are unique to land plants, are involved in the regulation of abiotic stress response and related signaling pathways, and play a crucial role in plant growth and development. Dendrobium is one of the largest genera of orchids, with a high ornamental and ecological value. However, the specific functions of the ZF-HDs in Dendrobium remain unknown. In this study, we identified a total of 53 ZF-HDs from D. chrysotoxum (17), D. catenatum (23), and D. huoshanense (13), and analyzed their physicochemical properties, phylogenetic relationships, chromosomal locations, protein structures, conserved motifs, and expression patterns. The phylogenetic relationships revealed that 53 ZF-HDs were classified into six subfamilies (ZHDI–V and MIF), and all ZF-HD proteins contained motif 1 and motif 4 conserved domains, while a minority of these proteins had exons. The analysis of cis-elements in the promoters of ZF-HDs from three Dendrobium species showed that growth- and development-related elements were the most prevalent, followed by hormone response and abiotic stress response elements. Through collinearity analysis, 14 DchZF-HDs were found to be collinear with DhuZF-HDs, and 12 DchZF-HDs were found to be collinear with DcaZF-HDs. Furthermore, RT-qPCR analysis revealed that DchZF-HDs play a regulatory role in the development of lateral organs during the flowering process. The results indicated that DchZHD2 plays a role in the unpigmented bud stage, while DchMIF8 and DchZHD16 play significant roles during the pigmented bud and initial bloom stages. Hence, this study provides a crucial basis for further exploring ZF-HDs functions in regulating the floral organs of orchids. Full article

In this study, a beverage made from a combination of Agave sap (AS) and prickly pear juice (PPJ) was analyzed for its nutrients and bioactive and potentially health-promoting compounds. The beverage was evaluated for its ability to act as an antioxidant, regulate glycemic properties, and undergo gut bacterial fermentation in vitro. The major mono- and oligosaccharides present in the beverage were galacturonic acid (217.74 ± 13.46 mg/100 mL), rhamnose (227.00 ± 1.58 mg/100 mL), and fructose (158.16 ± 8.86 mg/mL). The main phenolic compounds identified were protocatechuic acid (440.31 ± 3.06 mg/100 mL) and catechin (359.72 ± 7.56 mg/100 mL). It was observed that the beverage had a low glycemic index (<40) and could inhibit digestive carbohydrases. The combination of ingredients also helped to reduce gas production during AS fermentation from 56.77 cm³ to 15.67 cm³. The major SCFAs produced during fermentation were butyrate, acetate, and propionate, with valerate being produced only during the late fermentation of the AS. This beverage is rich in bioactive compounds, such as polyphenols and dietary fiber, which will bring health benefits when consumed. Full article

Iron deficiency is the number one nutritional problem worldwide. Iron uptake is regulated at the intestine and is highly influenced by the gut microbiome. Blood from the intestines drains directly into the liver, informing iron status and gut microbiota status. Changes in either iron or the microbiome are tightly correlated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD). To investigate the underlying mechanisms of the development of MASLD that connect altered iron metabolism and gut microbiota, we compared specific pathogen free (SPF) or germ-free (GF) mice, fed a normal or low-iron diet. SPF mice on a low-iron diet showed reduced serum triglycerides and MASLD. In contrast, GF low-iron diet-fed mice showed increased serum triglycerides and did not develop hepatic steatosis. SPF mice showed significant changes in liver lipid metabolism and increased insulin resistance that was dependent upon the presence of the gut microbiota. We report that total body loss of mitochondrial iron importer Mitoferrin2 (Mfrn2⁻/⁻) exacerbated the development of MASLD on a low-iron diet with significant lipid metabolism alterations. Our study demonstrates a clear contribution of the gut microbiome, dietary iron, and Mfrn2 in the development of MASLD and metabolic syndrome. Full article

Head and neck cancers rank as the sixth most prevalent cancers globally. In addition to traditional risk factors such as smoking and alcohol use, human papillomavirus (HPV) infections are becoming a significant causative agent of head and neck cancers, particularly among Western populations. Although HPV offers a significant survival benefit, the search for better biomarkers is still ongoing. In the current study, our objective was to investigate whether the expression levels of three PDZ-domain-containing proteins (SCRIB, NHERF2, and DLG1), known HPV E6 cellular substrates, influence the survival of HNSCC patients treated by primary surgery (n = 48). Samples were derived from oropharyngeal and oral cancers, and HPV presence was confirmed by PCR and p16 staining. Clinical and follow-up information was obtained from the hospital database and the Croatian Cancer registry up to November 2023. Survival was evaluated using the Kaplan–Meier method and Cox proportional hazard regression. The results were corroborated through the reanalysis of a comparable subset of TCGA cancer patients (n = 391). In conclusion, of the three targets studied, only SCRIB levels were found to be an independent predictor of survival in the Cox regression analysis, along with tumor stage. Further studies in a more typical Western population setting are needed since smoking and alcohol consumption are still prominent in the Croatian population, while the strongest association between survival and SCRIB levels was seen in HPV-negative cases. Full article

This research aims to contribute to the development of the Eco-LeanSat concept by focusing on a sustainable approach to satellite manufacturing and the repurposing of remaining satellite capabilities after failure. Despite satellites no longer being suitable for their original purposes, these remaining capabilities can find new applications. The study begins by identifying relevant innovative eco-design applications. Subsequently, it examines sustainability within the satellite lifecycle supply chain, categorizing it into four methods: (1) active debris removal, (2) transport logistics, (3) mission extension, and (4) repair and construction. Aligned with emerging trends in space activities, the study also considers future developments to maximize satellites’ potential to provide new services. Additionally, the research includes a description of a potential lean manufacturing process that encompasses logistic chains to support the development of a more sustainable space economy. Finally, the study concludes with a technological survey tracing the evolution of the development of the SmallSat and CubeSat platforms that identifies relevant innovative designs for a sustainable space environment. Full article

This study aimed to investigate the effects of yeast cultures on the antioxidant capacity, rumen fermentation, and growth performance of goats in the summer. An in vitro experiment was conducted using yeast culture supplemented at 0% (control), 0.6% (test 1), 0.9% (test 2), and 1.2% (test 3) of the dry matter (DM) weight of the basal diet. With a 24 h fermentation, the pH value; the total short-chain fatty acid, acetic acid, propionic acid, and butyric acid concentrations; and the degradability of the DM, the neutral detergent fiber, and the acid detergent fiber were significantly increased (p < 0.05) in tests 2 and 3 compared with the control group. In the feeding experiment, thirty-six crossbreed goats aged 3.0 ± 0.5 months with a body weight of 11.08 ± 1.41 kg were divided, and the yeast culture was supplemented at 0% (control), 0.90% (test 1), and 1.20% (test 2) of the basal diet. Similar effects on rumen fermentation parameters were obtained in test 1 and 2 groups compared to the in vitro experiment. Moreover, the dry matter intake, average daily gain, serum total antioxidant capacity, and the activities of total superoxide dismutase and glutathione peroxidase were significantly higher and the malondialdehyde concentration was significantly lower (p < 0.05) in tests 1 and 2 compared with the control. The results indicated that yeast culture (0.90%) could improve the antioxidant capacity, rumen fermentation, and growth performance of goats in summer. The optimal supplementation concentration is 0.90% DM. Full article

The PRESERVE study (NCT04972097) aims to evaluate the safety and effectiveness of the NanoKnife System to ablate prostate tissue in patients with intermediate-risk prostate cancer (PCa). The NanoKnife uses irreversible electroporation (IRE) to deliver high-voltage electrical pulses to change the permeability of cell membranes, leading to cell death. A total of 121 subjects with organ-confined PCa ≤ T2c, prostate-specific antigens (PSAs) ≤ 15 ng/mL, and a Gleason score of 3 + 4 or 4 + 3 underwent focal ablation of the index lesion. The primary endpoints included negative in-field biopsy and adverse event incidence, type, and severity through 12 months. At the time of analysis, the trial had completed accrual with preliminary follow-up available. Demographics, disease characteristics, procedural details, PSA responses, and adverse events (AEs) are presented. The median (IQR) age at screening was 67.0 (61.0–72.0) years and Gleason distribution 3 + 4 (80.2%) and 4 + 3 (19.8%). At 6 months, all patients with available data (n = 74) experienced a median (IQR) percent reduction in PSA of 67.6% (52.3–82.2%). Only ten subjects (8.3%) experienced a Grade 3 adverse event; five were procedure-related. No Grade ≥ 4 AEs were reported. This study supports prior findings that IRE prostate ablation with the NanoKnife System can be performed safely. Final results are required to fully assess oncological, functional, and safety outcomes. Full article