Chronic liver disease is one of the main causes of morbidity and mortality in people living with HIV (PLWH). The increasing life expectancy of PLWH, effective treatment for viral hepatitis, and Western dietary patterns as well as the adverse effects of antiretroviral therapy (ART) have rendered metabolic dysfunction-associated steatotic liver disease (MASLD) the most common chronic liver disease in PLWH. The risk factors for MASLD in PLWH include traditional MASLD risk factors and additional virus-specific factors, including the adverse effects of ART. The management of patients suffering from HIV and MASLD is often challenging. Apart from the conventional management of MASLD, there are also certain limitations concerning the use of ART in this patient population. In general, the appropriate combination of antiretroviral drugs should be chosen to achieve the triad of effective viral suppression, avoidance of mitochondrial dysfunction, and deterrence of worsening the patient’s metabolic profile. In the current review, we discuss the epidemiology of MASLD in PLWH, the risk factors, and the disease pathogenesis, as well as the limitations in the use of ART in this patient population, while practical recommendations on how to overcome these limitations are also given. Full article

Modern electric motors developed for the automotive industry have an ever higher power density with a relatively compact size. Among the various existing solutions to improve torque and power density, a reduction in the dimensions of the end-windings has been explored, aiming to decrease volume, weight, and losses. However, more compact end-windings often lead to complex shapes of the conductors, especially when preformed hairpin windings are considered. The rectangular cross-section of hairpin conductors makes them prone to deviating out of the bending plane during the forming process. This phenomenon, known as torsional–flexural instability, is influenced by the specific aspect ratio of the cross-section dimensions and the bending direction. This study focuses on understanding this instability phenomenon, aiming to identify a potential threshold of the cross-section aspect ratio. The instability makes it difficult to predict the final geometry, potentially compromising the compliance with the geometric tolerances. A finite element model is developed to analyse a single planar bend in a hairpin conductor. Various cross-section dimensions with different aspect ratios are simulated identifying those that experience instability. Moreover, an experimental campaign is conducted to confirm the occurrence of instability by testing the same single planar bending. The experimental data obtained are used to validate the finite element model for the tested dimensions. The aim is to provide designers with a useful tool to select hairpin geometries that are more suitable for the folding process, contributing to successful assembly and improving the overall design process of preformed hairpin conductors. Full article

Achromobacter insolitus and Achromobacter aegrifaciens, bacterial degraders of the herbicide glyphosate, were found to induce phosphonatase (phosphonoacetaldehyde hydrolase, EC 3.11.1.1) when grown on minimal media with glyphosate as the sole source of phosphorus. The phosphonatases of the strains were purified to an electrophoretically homogeneous state and characterized. The enzymes differed in their kinetic characteristics and some other parameters from the previously described phosphonatases. The phosphonatase of A. insolitus was first revealed to separate into two stable forms, which had similar kinetic characteristics but interacted differently with affinity and ion-exchange resins. The genomes of the investigated bacteria were sequenced. The phosphonatase genes were identified, and their context was determined: the bacteria were shown to have gene clusters, which, besides the phosphonatase operon, included genes for LysR-type transcription activator (substrate sensor) and putative iron-containing oxygenase PhnHD homologous to monooxygenases PhnY and TmpB of marine organophosphonate degraders. Genes of 2-aminoethylphosphonate aminotransferase (PhnW, EC 2.6.1.37) were absent in the achromobacterial phosphonatase operons; instead, we revealed the presence of genes encoding the putative flavin oxidase HpnW. In silico simulation showed 1-hydroxy-2-aminoethylphosphonate to be the most likely substrate of the new monooxygenase, and a number of glycine derivatives structurally similar to glyphosate to be substrates of flavin oxidase. Full article

The sweetpotato whitefly, Bemisia tabaci MEAM1, is a pest known to significantly impact tomato development and yields through direct damage and virus transmission. To manage this pest, the current study compared the effectiveness of various insecticide rotations. Field trials included rotations involving synthetic insecticides, biochemicals, and microbial agents, applied according to their highest labeled concentrations. The results indicated that while standard synthetic insecticides consistently reduced whitefly egg and nymph counts significantly, microbial biopesticide rotations also achieved reductions, although less consistently. This study demonstrated that while traditional chemical treatments remain highly effective, microbial biopesticides containing Beauveria bassiana and Cordyceps javanica present a viable alternative to manage MEAM1 in tomato fields. The data generated in this study provided baseline information for further investigations to determine the potential for optimizing integrated pest management (IPM) and insecticide resistance management (IRM) strategies by incorporating microbial biopesticides in rotations with a variety of modes of action to sustainably manage B. tabaci MEAM1 populations in agricultural settings. Full article

Artificial corner reflectors are widely used in the vegetated landslide for time series InSAR monitoring due to their permanent scattering features. This paper investigated the RCS features of a novel dihedral CR under multi-resource SAR datasets. An RCS reduction model for the novel dihedral corner reflector has been proposed to evaluate the energy loss caused by the deviation between the SAR incident angle and the CR’s axis. On the Huangtupo slope, Badong county, Hubei province, tens of dihedral CRs had been installed and the TSX–spotlight and Sentinel-TOPS data had been collected. Based on the observation results of CRs with more than ten deviation angles, the proposed reduction model was tested with preferable consistency under a real dataset, while 2 dBsm of systematic bias was verified in those datasets. The maximum incident angle deviation in the Sentinel data overlapping area is over 12°, which leads to a 2.4 dBsm RCS decrease for horizontally placed dihedral CRs estimated by the proposed model, which has also been testified by the observed results. The testing results from the Sentinel data show that in high, vegetation-covered mountain areas like the Huangtupo slope, the dihedral CRs with a 0.4 m slide length can be achieve 1 mm precision accuracy, while a side length of 0.2 m can achieve the same accuracy under TSX–spotlight data. Full article

This paper proposes a temperature-adaptive radiative cooling (TARC) coating with simple preparation, cost effectiveness, and large-scale application based on a thermochromic powder. To determine the energy efficiency of the proposed TARC coating, the heat transfer on the surface of the TARC coating was analyzed. Then, a typical two-story residential building with a roof area of 258.43 m² was modeled using EnergyPlus. Finally, the energy-saving potential and carbon emission reduction resulting from the application of the proposed TARC roof in buildings under different climates in China were discussed. The results showed that the average solar reflectivity under visible light wavelengths (0.38–0.78 μm) decreases from 0.71 to 0.37 when the TARC coating changes from cooling mode to heating mode. Furthermore, energy consumption can be reduced by approximately 17.8–43.0 MJ/m² and 2.0–32.6 MJ/m² for buildings with TARC roofs compared to those with asphalt shingle roofs and passive daytime radiative cooling (PDRC) roofs, respectively. This also leads to reductions in carbon emissions of 9.4–38.0 kgCO₂/m² and 1.0–28.9 kgCO₂/m² for the buildings located in the selected cities. To enhance building energy efficiency, TARC roofs and PDRC roofs are more suitable for use on buildings located in zones with high heating demands and high cooling demands, respectively. Full article

In this study, six different animal models were fitted, and the constrained maximum likelihood method was used to assess the genetic parameters and genetic trends of early growth traits in Luzhong mutton sheep. The experimental data of this study included the newborn weight (BWT, N = 2464), weaning weight (WWT, N = 2923), weight at 6 months of age (6WT, N = 2428), average daily weight gain from birth to weaning (ADG1, N = 2424), and average daily weight gain from weaning to 6 months of age (ADG2, N = 1836) in Luzhong mutton sheep (2015~2019). The best model for the genetic parameters of the five traits in Luzhong mutton sheep was identified as Model 4 using the Akaike information criterion (AIC) and likelihood ratio test (LRT) methods, in which the estimated values of direct heritability for the BWT, WWT, 6WT, ADG1, and ADG2 were 0.156 ± 0.057, 0.547 ± 0.031, 0.653 ± 0.031, 0.531 ± 0.035, and 0.052 ± 0.046, respectively, and the values for maternal heritability were 0.201 ± 0.100, 0.280 ± 0.047, 0.197 ± 0.053, 0.275 ± 0.052, and 0.081 ± 0.092, respectively. The genetic correlation between the ADG2 and WWT was negative, and the genetic and phenotypic correlations among the remaining traits were positive. In this study, maternal effects had a more significant influence on early growth traits in Luzhong mutton sheep. In conclusion, to effectively improve the accuracy of genetic parameter estimation, maternal effects must be fully considered to ensure more accurate and better breeding planning. Full article

This paper presents a new layered plaster-based material for building purposes. First, a new manufacturing machine was designed to make the elaboration process easier. This manufacturing machine and the way it works are described. In this study, perlite and recycled glass wool (RGW) were added to traditional plaster with the aim of improving the performance of this material. Two series (with and without perlite) and three different layer configurations were developed and assessed. Recycled glass wool layered materials were subjected to both physical and mechanical characterisation to determine their suitability for precast elaboration. The addition of perlite resulted in a significant improvement in flexural strength. Moreover, the addition of RGW also gave rise to extra flexural strength when added. The two-layered samples performed better than the one-layered samples. Mechanical properties increased up to 75% when both the perlite and RGW layers were added. Potential Global Warming Potential (GWP 100) savings were also analysed, reporting up to 49% savings. A complementary cost analysis was performed, aimed at establishing potential savings in production costs; thus, 13–57% potential cost savings were reported. After that, a comparative analysis within the literature was conducted to contextualise the results obtained in this study. Full article

The topographical turn in literary and cultural studies has shed new light on the deeply symbolic significance of the natural and urban places where stories unfold. This focus on spatiality is particularly evident in the South Asian literature by contemporary women writers, where locations acquire a personality and significantly contribute to the shaping of gender identities. Although most of these narratives portray female protagonists who develop strategies of resistance and sisterhood within traditional domestic spaces, the widely praised transnational novels Brick Lane and The Mistress of Spices show that women can also achieve independence and self-realization in the bustling urban environment. Drawing on cultural geography as well as gender and social studies, this essay argues that the global dimension of the city offers diasporic women the opportunity to forge new empowered selves in the above-mentioned books. First, the article maintains that London and Oakland, CA, where the main characters live, exert a centripetal force on women, thus triggering change and mobility, both in physical and psychical terms. Second, it claims that the two cities are gendered “heterotopias”, i.e., heterogeneous spaces where border-crossing women, like those featured in the two novels at hand, can overcome alienation and develop creativity, resilience, and self-confidence. In conclusion, urban spaces serve as “safe houses” for immigrant women, where they can cure their emotional and physical diseases and become figures of adaptive hybridity. Full article

The main challenge in milk production has been to maintain a focus on efficient processes that enhance production outcomes while aligning with animal welfare and sustainability and being valued by society. As an alternative to improve cow welfare in production and provide better handling of the waste generated by the activity, the system called the compost-bedded pack barn (CBP) has been widely adopted in countries with temperate climates and higher milk production. This CBP has been attracting global interest, including from countries with tropical and subtropical climates, such as Brazil, where many producers have started to use it due to the response in terms of milk productivity. A CBP can be designed either in (a) an open facility with natural ventilation or a positive-pressure ventilation system or (b) totally closed facilities, equipped with negative-pressure ventilation systems and permanent thermal control. The latter system is being implemented in Brazil, despite insufficient knowledge about its efficiency. The objective of this study was, through a review, to gather and describe the most recent information on the use of open and closed CBP systems for dairy cattle housing, mainly covering how it is applied in tropical climate regions. To achieve the proposed objective, this review study included the following topics related to CBPs: (i) implementation, (ii) bedding, (iii) general construction and architectural characteristics, and (iv) ambient thermal conditioning. Knowledge gaps and directions for future research are also identified here. Full article

Smell loss affects around 15–20% of the population, with a major effect on the quality of life. The most common complaint is the impairment of the eating experience, with around 90% of patients reporting this issue. A study conducted at a specialised Taste and Smell Clinic investigated if food and cooking can positively affect the enjoyment of food, subjective cooking skills, and quality of life in patients with smell loss. The 49 participants in the study received a 5-week cooking school course that focused on emphasizing the other senses to regain the enjoyment of food. Participants gained more confidence in cooking, and their quality of life improved significantly. Positively evaluated recipes were adjusted based on feedback and published as free e-books in Danish, German, and English. Eating and cooking are multisensory experiences, and the perception of food depends on the complex interaction of senses and surroundings. If the olfactory input is reduced or absent, both the enjoyment and cooking experience can be negatively affected. Therefore, focusing on food and cooking can have a positive impact on patients with smell loss. Full article

The aim of this paper is to study the use of Lambert W functions in the analysis of nonlinear dynamics and bifurcations of a new two-dimensional $\gamma$-Ricker population model. Through the use of such transcendental functions, it is possible to study the fixed points and the respective eigenvalues of this exponential diffeomorphism as analytical expressions. Consequently, the maximum number of fixed points is proved, depending on whether the Allee effect parameter $\gamma$ is even or odd. In addition, the analysis of the bifurcation structure of this $\gamma$-Ricker diffeomorphism, also taking into account the parity of the Allee effect parameter, demonstrates the results established using the Lambert W functions. Numerical studies are included to illustrate the theoretical results. Full article

Malicious reverse engineering of software has served as a valuable technique for attackers to infringe upon and steal intellectual property. We can employ obfuscation techniques to protect against such attackers as useful tools to safeguard software. Applying obfuscation techniques to source code can prevent malicious attackers from reverse engineering a program. However, the ambiguity surrounding the protective efficacy of these source code obfuscation tools and techniques presents challenges for users in evaluating and comparing the varying degrees of protection provided. This paper addresses these issues and presents a methodology to quantify the effect of source code obfuscation. Our proposed method is based on three main types of data: (1) the control flow graph, (2) the program path, and (3) the performance overhead added to the process—all of which are derived from a program analysis conducted by human experts and automated tools. For the first time, we have implemented a tool that can quantitatively evaluate the quality of obfuscation techniques. Then, to validate the effectiveness of the implemented framework, we conducted experiments using four widely recognized commercial and open-source obfuscation tools. Our experimental findings, based on quantitative values related to obfuscation techniques, demonstrate that our proposed framework effectively assesses obfuscation quality. Full article

Inflammation and thrombosis are implicated in several chronic disorders. Recent studies have outlined the way in which several compounds can offer protection against inflammation. Within this comprehensive review the so-far reported anti-inflammatory health-promoting effects of several metal-based complexes, both in vitro and in vivo, are thoroughly presented. These metal-based compounds usually interfere with various biochemical processes associated with the inflammatory response and thrombus formation and become capable of inhibiting these biochemical pathways with proposed health benefits. Emphasis is given to the multifaceted actions of metal-based complexes that have exhibited potent anti-inflammatory and antithrombotic activities against the inflammatory mediator, platelet-activating factor (PAF), and its thrombo-inflammatory signaling, as well as on their anti-platelet and antitumor health promoting properties. Furthermore, the enhancement of the anti-inflammatory potency of well-established bioactive compounds by their incorporation as ligands in several metal-based complexes is discussed. Metal-based complexes bearing natural anti-inflammatory bioactives are also outlined. Characteristic examples of both free and metal-based porphyrins are explored. These compounds are recognized to have anti-inflammatory and antithrombotic assets, in addition to other pleiotropic advantages including antibacterial or anticancer actions. Additionally, applications of metal complexes in various models of inflammatory and thrombotic complications are demonstrated. The combined results of this study show that further research is required towards the preparation of several metal-based complexes with improved pharmacological profiles. Finally, restrictions on the application of these metal-based compounds are also covered, along with their prospects for the future and the need for additional study in order to improve their efficacy and safety. Full article

Heusler alloys, which were unintentionally discovered at the start of the 20^th century, have become intriguing materials for many extraordinary functional applications in the 21^st century, including smart devices, spintronics, magnetic refrigeration and the shape memory effect. With this review article, we would like to provide a comprehensive review on the recent progress in the development of Heusler alloys, especially Ni-Mn based ones, focusing on their structural crystallinity, order-disorder atoms, phase changes and magnetic ordering atoms. The characterization of the different structures of these types of materials is needed, where a detailed exploration of the crystal structure is presented, encompassing the influence of temperature and compositional variations on the exhibited phases. Hence, this class of materials, present at high temperatures, consist of an ordered austenite with a face-centered cubic (FCC) superlattice as an L2₁ structure, or body-centered cubic (BCC) unit cell as a B2 structure. However, a low-temperature martensite structure can be produced as an L10, 10M or 14M martensite structures. The crystal lattice structure is highly dependent on the specific elements comprising the alloy. Additionally, special emphasis is placed on phase transitions within Heusler alloys, including martensitic transformations ranging above, near or below room temperature and magnetic transitions. Therefore, divers’ crystallographic defects can be presented in such types of materials affecting their structural and magnetic properties. Moreover, an important property of Heusler compounds, which is the ability to regulate the valence electron concentration through element substitution, is discussed. The possible challenges and remaining issues are briefly discussed. Full article

The low-pressure die casting (LPDC) process was experimentally and numerically studied to produce AlSi7Mg0.3 components such as steering knuckles. Steering knuckles are important safety components in the context of a vehicle’s suspension system, serving as the mechanical interface that facilitates the articulation of the steering to control the front wheel’s orientation, while simultaneously bearing the vertical load imposed by the vehicle’s weight. This work focuses on the development of a numerical model in ProCAST^®, replicating the production of the aforementioned part. The model analyses parameters such as the filling dynamics, solidification process, and presence of shrinkage porosities. For the purpose of evaluating the quality of the castings, six parts were produced and characterised, both mechanically (tensile and hardness tests) and microstructurally (porosity and optical microscopy analysis). When correlating simulation results with the available experimental data, it is possible to conclude that the usage of the LPDC process is a viable alternative to the use of steels and other metals for the production of very high-quality castings while using lighter alloys such as aluminium and magnesium in more demanding applications. Full article

Context/Objective: In order to better understand which metabolic differences are related to insulin resistance in metabolic syndrome (MetSyn), we used hyperinsulinemic–euglycemic (HE) clamps in individuals with MetSyn and related peripheral insulin resistance to circulating biomarkers. Design/Methods: In this cross-sectional study, HE-clamps were performed in treatment-naive men (n = 97) with MetSyn. Subjects were defined as insulin-resistant based on the rate of disappearance (Rd). Machine learning models and conventional statistics were used to identify biomarkers of insulin resistance. Findings were replicated in a cohort with n = 282 obese men and women with (n = 156) and without (n = 126) MetSyn. In addition to this, the relation between biomarkers and adipose tissue was assessed by nuclear magnetic resonance imaging. Results: Peripheral insulin resistance is marked by changes in proteins related to inflammatory processes such as IL-1 and TNF-receptor and superfamily members. These proteins can distinguish between insulin-resistant and insulin-sensitive individuals (AUC = 0.72 ± 0.10) with MetSyn. These proteins were also associated with IFG, liver fat (rho 0.36, p = 1.79 × 10⁻⁹) and visceral adipose tissue (rho = 0.35, p = 6.80 × 10⁻⁹). Interestingly, these proteins had the strongest association in the MetSyn subgroup compared to individuals without MetSyn. Conclusions: MetSyn associated with insulin resistance is characterized by protein changes related to body fat content, insulin signaling and pro-inflammatory processes. These findings provide novel targets for intervention studies and should be the focus of future in vitro and in vivo studies. Full article

The prevalence of Helicobacter pylori (H. pylori), a pathogen, has decreased globally in the last decade. To date, the management of H. pylori has focused on a reactive approach, whereby those diagnosed are treated with antimicrobials and acid suppression in combination. This review article provides an overview of the shift in the management of H. pylori from a reactive approach towards a proactive ‘screen and treat’ approach; the article reflects the current pharmacological landscape for H. pylori treatment by exploring similarities such as the first-line prescription of quadruple therapy in most countries and provides a summary table of the best practice guidance from Europe, Asia, and North America. It explores significant ongoing challenges in management, such as rising antimicrobial resistance rates, and explores a potential ‘work smart’ approach to antimicrobial susceptibility testing. We explore the role of registry databases in providing data on treatment efficacy and safety and how they can support a strategic approach to H. pylori treatment. We question if such a database’s availability, update, and regular audit should serve as a key quality indicator in a population screening programme. Despite a call for vaccination against H. pylori and decades of research, not many have made it to a phase-three clinical trial. We explore the challenges that have complicated the development of such a vaccine, such as the genetic diversity of H. pylori, immunotolerance, and limitations of mouse models in research; we reflect on how these challenges are contributing to a low likelihood of having a vaccine in the short–medium term. Lastly, it explores the heterogeneity in research on probiotics and their role as an adjunct in the management of H. pylori. Full article

(1) Background: Although culturally grounded health interventions (CGHI) have shown efficacy in improving Indigenous health, few CGHI for Queer and Transgender Pacific Islander (QTPI) communities exist to address their health promotion. This study explores QTPI experiences of health for cultural mechanisms to develop CGHI for QTPI health promotion. (2) Methods: Using Indigenist community-engaged research methodologies, we collaborated with the United Territories of Pacific Islanders Alliance of Washington and Guma’ Gela’ to conduct 11 exploratory semi-structured interviews with QTPI community members living in the Puget Sound area of Washington state. These interviews were analyzed using thematic analysis. (3) Results: QTPI well-being was greatly influenced by how settler colonialism impacted their connectedness to their families, communities, and cultures. We also found that inágofli’e’ and alofa, relational values in CHamoru and Sāmoan culture, played essential roles in facilitating QTPI health. Many participants fostered these values through chosen family, community care, and Indigenous mobilities. (4) Conclusions: Our findings indicate a need for CGHI that facilitate inágofli’e’ and alofa for QTPI to combat settler colonialism’s impacts on QTPI well-being. Finally, we present a community-centered conceptual model for culturally grounded health promotion in QTPI communities. Full article

The antimicrobial resistance of Neisseria gonorrhoeae (NG) is an increasing public health concern, highlighted by the fact that gonococcus is considered as a ‘high’-priority pathogen by the WHO for research and development of new therapeutic options. According to the data of the European Centre for Disease Prevention and Control (ECDC) in 2022, the rate of NG infections is the highest recorded since European surveillance of sexually transmitted infections began in 2009. We report a brief description of a patient infected with two different isolates of drug-resistant N. gonorrhoeae. N. gonorrhoeae cultures were positive from oropharyngeal and urethral swabs and isolates had different antimicrobial susceptibility. We investigated the antimicrobial susceptibility of these isolates to six antimicrobials (ceftriaxone, cefixime, azithromycin, ciprofloxacin, tetracycline, and benzylpenicillin), and minimum inhibitory concentrations (MICs; mg/L) were determined using Etest on gonococcal isolates. Oropharyngeal isolate was resistant to azithromycin while urethral was resistant to penicillin, ciprofloxacin, and tetracycline. Two different and phylogenetically distinct sequence types of NG isolates were identified. Understanding the dynamics and drivers of resistance spread can provide an improved rationale for antibiotic management, and the level of NG resistance should be monitored closely. Full article

The rupture of unstable plaques is a major cause of acute cardiovascular events. The early assessment of carotid plaques can significantly reduce the cardiovascular risks, so developing evaluation models suitable for data from different centers is of great clinical importance. This study leverages plaque datasets from multiple centers to develop a Weighted multi-source carotid artery plaque Unsupervised Classification Framework (WUCF). The multi-source domain adaptation module of the WUCF focuses on maintaining feature consistency between each independent source and target center, while also integrating a specialized domain discriminator expert. This ensures that the knowledge from each source center is effectively learned and combined for accurate predictions in the target domain. The experimental evaluation of WUCF, using datasets from three centers, has demonstrated the method’s superiority and robustness. Full article

Nonsense mutations are genetic mutations that create premature termination codons (PTCs), leading to truncated, defective proteins in diseases such as cystic fibrosis, neurofibromatosis type 1, Dravet syndrome, Hurler syndrome, Beta thalassemia, inherited bone marrow failure syndromes, Duchenne muscular dystrophy, and even cancer. These mutations can also trigger a cellular surveillance mechanism known as nonsense-mediated mRNA decay (NMD) that degrades the PTC-containing mRNA. The activation of NMD can attenuate the consequences of truncated, defective, and potentially toxic proteins in the cell. Since approximately 20% of all single-point mutations are disease-causing nonsense mutations, it is not surprising that this field has received significant attention, resulting in a remarkable advancement in recent years. In fact, since our last review on this topic, new examples of nonsense suppression approaches have been reported, namely new ways of promoting the translational readthrough of PTCs or inhibiting the NMD pathway. With this review, we update the state-of-the-art technologies in nonsense suppression, focusing on novel modalities with therapeutic potential, such as small molecules (readthrough agents, NMD inhibitors, and molecular glue degraders); antisense oligonucleotides; tRNA suppressors; ADAR-mediated RNA editing; targeted pseudouridylation; and gene/base editing. While these various modalities have significantly advanced in their development stage since our last review, each has advantages (e.g., ease of delivery and specificity) and disadvantages (manufacturing complexity and off-target effect potential), which we discuss here. Full article