Cardiovascular diseases (CVDs) are often associated with impaired nitric oxide (NO) bioavailability, a critical pathophysiological alteration in CVDs and an important target for therapeutic interventions. Recent studies have revealed the potential of inorganic nitrite and nitrate as sources of NO, offering promising alternatives for managing various cardiovascular conditions. It is now becoming clear that taking advantage of enzymatic pathways involved in nitrite reduction to NO is very relevant in new therapeutics. However, recent studies have shown that nitrite may be bioactivated in the acidic gastric environment, where nitrite generates NO and a variety of S-nitrosating compounds that result in increased circulating S-nitrosothiol concentrations and S-nitrosation of tissue pharmacological targets. Moreover, transnitrosation reactions may further nitrosate other targets, resulting in improved cardiovascular function in patients with CVDs. In this review, we comprehensively address the mechanisms and relevant effects of nitrate and nitrite-stimulated gastric S-nitrosothiol formation that may promote S-nitrosation of pharmacological targets in various CVDs. Recently identified interfering factors that may inhibit these mechanisms and prevent the beneficial responses to nitrate and nitrite therapy were also taken into consideration. Full article

Introduction: This report investigates late-stage internal derangement (ID) of the temporomandibular joint (TMJ) with the aim of establishing a more effective and personalized treatment protocol to improve patients’ quality of life (QoL). Material and methods: A consensus was reached among maxillofacial surgeons specializing in LSID, based on a literature research and collective expert experience following the Delphi method. Consensus was considered to be achieved when a response received at least 80% of votes. Results: Four expert groups were established, respectively, focusing on diagnosis, minimally invasive surgery (MIS), open surgery and joint replacement. A comprehensive approach to late-stage ID of the TMJ requires a consensus report. This underscores the need for a personalized treatment plan, considering the variability in clinical presentations and progression of this pathology. Our recommendations aim to optimize clinical outcomes and enhance patient QoL. Full article

The automotive industries currently face challenges such as emission limits, traffic congestion, and limited parking, which have prompted shifts in consumer preferences and modern passenger vehicle requirements towards compact vehicles. However, given the inherent limited width of compact vehicles, the potential risk of vehicle rollover is greater than that of regular vehicles. This paper addresses the safety concerns associated with vehicle rollover, focusing on narrow tilting vehicles (NTVs). Quantifying stability involves numerical indicators such as the lateral load transfer ratio (LTR). Additionally, a unique approach is taken by applying ZMP (zero moment point), commonly used in the robotics field, as an indicator of vehicle stability. Effective roll control requires a detailed analysis of the vehicle’s characteristic model and the derivation of lateral and roll dynamics. The paper presents the detailed roll dynamics of an NTV with a MacPherson strut-type suspension. A stability-enhancing method is proposed using a cascade structure based on the internal robust position controller and outer roll stability controller, addressing challenges posed by disturbances. Experimental verification using Simscape Multibody and CarSim validates the dynamic model and controller’s effectiveness, ensuring the reliability of the proposed tilting control for NTVs in practical scenarios. Full article

Land Surface Temperature (LST) is an important climate factor for understanding the relationship between the land surface and atmosphere. Furthermore, LST is linked to soil moisture and evapotranspiration, which can potentially alter the severity and regime of wildfires, landslide-triggering precipitation thresholds, and others. In this paper, the monthly daytime and nighttime LST products of Moderate Resolution Imaging Spectroradiometer (MODIS) are employed for the period 2000–2023 in order to find areas that have been cooling or warming in a region of great interest in Central Italy, due to its complex geological and geomorphological settings and its recent seismic sequences and landslide events. The annual MODIS land cover images for 2001–2022 are also utilized to investigate the interconnection between LST and land cover change. The results of the non-parametric Mann–Kendall trend test and its associated Sen’s slope reveal a significant nighttime warming trend in the region, particularly in July, linked to forest and woodland expansion. Grasslands toward the coastline with low elevation (less than 500 m a.s.l.) have experienced significant heat waves during the summer, with an LST of more than 35 ${}^{\circ }$C. A significant negative correlation between the elevation and LST is observed for each calendar month. In particular, the daytime and nighttime LST have more than 80% correlation with elevation during winter and summer, respectively. In addition, nighttime warming and gradual drainage are noticed in Lake Campotosto. The results of this study could be useful for wildfire and landslide susceptibility analyses and hazard management. Full article

Thiosulfate leaching has been regarded as a promising alternative to cyanidation, but it still faces the challenge of the recovery of low content of gold from high concentrations of thiosulfate solutions. Liquid–liquid extraction is a method to address this issue but is still limited by the use of volatile and toxic organic solvents. To overcome this limitation, this work synthesized some functionalized dicationic ionic liquids (DILs) to serve as extraction solvents for the recovery of the gold–thiosulfate complex, [Au(S₂O₃)₂]³⁻, from thiosulfate solutions. Experimental results indicated that the DILs showed higher extraction rates toward [Au(S₂O₃)₂]³⁻ compared with their monocationic-based counterparts, likely due to the stronger electrostatic interaction between the dications of the ILs and [Au(S₂O₃)₂]³⁻. The transfer of [Au(S₂O₃)₂]³⁻ from the water phase to the IL phase was identified as an anion exchange and endothermic process. The rate of extraction was limited by the anion exchange process occurring at the IL–water interface. The extraction ability of ILs highly depended on the type of anion; specifically, the ILs with anions that had strong hydrogen-bonding ability exhibited high extraction ability toward [Au(S₂O₃)₂]³⁻. Finally, DILs proved effective in the recovery of [Au(S₂O₃)₂]³⁻ from an actual gold leaching solution and exhibited high selectivity toward coexisting ions, indicating their potential as environmentally friendly solvents for gold recovery. Full article

In diabetes mellitus, disordered glucose and lipid metabolisms precipitate diverse complications, including nonalcoholic fatty liver disease, contributing to a rising global mortality rate. Theaflavins (TFs) can improve disorders of glycolipid metabolism in diabetic patients and reduce various types of damage, including glucotoxicity, lipotoxicity, and other associated secondary adverse effects. TFs exert effects to lower blood glucose and lipids levels, partly by regulating digestive enzyme activities, activation of OATP-MCT pathway and increasing secretion of incretins such as GIP. By the Ca²⁺-CaMKK ꞵ-AMPK and PI3K-AKT pathway, TFs promote glucose utilization and inhibit endogenous glucose production. Along with the regulation of energy metabolism by AMPK-SIRT1 pathway, TFs enhance fatty acids oxidation and reduce de novo lipogenesis. As such, the administration of TFs holds significant promise for both the prevention and amelioration of diabetes mellitus. Full article

Power-to-gas technology can be used to convert excess power from renewable energies to hydrogen by means of water electrolysis. This hydrogen can serve as “chemical energy storage” and be converted back to electricity or fed into the natural gas grid. In the presented study, a leak in a household pipe in a single-family house with a 13 kW heating device was experimentally investigated. An admixture of up to 40% hydrogen was set up to produce a scenario of burning leakage. Due to the outflow and mixing conditions, a lifted, turbulent diffusion flame was formed. This led to an additional examination point and expanded the aim and novelty of the experimental investigation. In addition to the fire safety experimental simulation of a burning leakage, the resulting complex properties of the flame, namely the lift-off height, flame length, shape and thermal radiation, have also been investigated. The obtained results of this show clearly that, as a consequence of the hydrogen addition, the main properties of the flame, such as lifting height, flame temperature, thermal radiation and total heat flux densities along the flame, have been changed. To supplement the measurements with thermocouples, imaging methods based on the Sobel gradient were used to determine the lifting height and the flame length. In order to analyze the determined values, a probability density function was created. Full article

This work reports the development of novel curcuminoid-based electrochemical sensors for the detection of environmental pollutants from water. In this study, the first set of electrochemical experiments was carried out using curcumin-conjugated multi-walled carbon nanotubes (MWCNT–CM) for 1,4-dioxane detection. The MWCNT–CM/GCE showed good sensitivity (103.25 nA nM⁻¹ cm⁻² in the linear range 1 nM to 1 µM), with LOD of 35.71 pM and LOQ of 108.21 pM. The second set of electrochemical experiments was carried out with bisdemethoxy curcumin analog quantum dots (BDMCAQD) for hydrazine detection. The BDMCAQD/GCE exhibited good sensitivity (74.96 nA nM⁻¹ cm⁻² in the linear range 100 nM to 1 µM), with LOD of 10 nM and LOQ of 44.93 nM. Thus, this work will serve as a reference for the fabrication of metal-free electrochemical sensors using curcuminoids as the redox mediator for the enhanced detection of environmental pollutants. Full article

In Romania, the pandemic and post-pandemic effects, coupled with the nearly 80% increase in internet service penetration, have led to an extraordinary acceleration of e-commerce activity. Rising rents and operational costs, heightened financial challenges, and the improved quality and accessibility of internet connectivity have prompted some Romanian SMEs to sell their products and services online or through other online communication networks. In this context, it becomes essential to conduct marketing research to identify factors that could stimulate business performance. The purpose of this study is to assess the impact of e-marketing orientation, sustainability orientation, and technology orientation on the performance of online SMEs in Romania. Hypothesis testing and validation of the proposed construct model were conducted using structural equation modeling with partial least squares (SEM-PLS) and multi-group analysis (PLS-MGA). The research results have indicated that all three independent variables have positive and significant effects on online SMEs’ business performance. Finally, the study suggests that SME managers should focus on integrating these three variables and on selling products and services both nationally and internationally through the internet if they aim for long-term business performance growth. Full article

Novel Nb-Si-based alloys with heterogeneous layers that have the same composition (Nb-16 at.%Si) but different phase morphologies were designed in this work. Heterogeneous layered structure (HLS) was successfully fabricated in Nb-16Si alloys by layering composite powders after various degrees of mechanical alloying (6 h, 12 h, 18 h, and 24 h) alternately and subsequent spark plasma sintering (SPS). The influence of HLS on the fracture behavior at both room and elevated temperature was investigated via single-edge notched bending (SENB) and high-temperature compression, respectively. The results show that the diversified HLS is obtained by combining hard layers containing fine equiaxed crystals and/or soft ones with coarse lamellar niobium solid solution (Nbss). By affecting the crack propagation in SENB, HLS is favorable for improving the fracture toughness and exhibits a significant increase compared with the corresponding homogenous microstructure. Moreover, for the same HLS, a more excellent performance is achieved when the initial crack is located in the soft layer and extended across the interface to the hard one through crack bridging, crack deflection, crack branching, and shielding effect. Fracture starts in the soft layer (from powders of ball-milled for 12 h) of a 12–24 alloy, and a maximum K_Q value (14.89 MPa·mm^1/2) is consequently obtained, which is 33.8% higher than that of the homogeneous Nb-16Si alloy. Furthermore, the heterogeneous layered alloys display superior high-temperature compression strength, which is attributable to the dislocation multiplication and fine-grained structure. The proposed strategy in this study offers a promising route for fabricating Nb-Si-based alloys with optimized and improved mechanical properties to meet practical applications. Full article

Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases worldwide. Some patients with MAFLD develop metabolic dysfunction-associated steatohepatitis (MASH), which can lead to severe liver fibrosis. However, the molecular mechanisms underlying this progression remain unknown, and no effective treatment for MASH has been developed so far. In this study, we performed a longitudinal detailed analysis of mitochondria in the livers of choline-deficient, methionine-defined, high-fat-diet (CDAHFD)-fed mice, which exhibited a MASH-like pathology. We found that FoF₁–ATPase activity began to decrease in the mitochondria of CDAHFD-fed mice prior to alterations in the activity of mitochondrial respiratory chain complex, almost at the time of onset of liver fibrosis. In addition, the decrease in FoF₁–ATPase activity coincided with the accelerated opening of the mitochondrial permeability transition pore (PTP), for which FoF₁–ATPase might be a major component or regulator. As fibrosis progressed, mitochondrial permeability transition (PT) induced in CDAHFD-fed mice became less sensitive to cyclosporine A, a specific PT inhibitor. These results suggest that episodes of fibrosis might be related to the disruption of mitochondrial function via PTP opening, which is triggered by functional changes in FoF₁–ATPase. These novel findings could help elucidate the pathogenesis of MASH and lead to the development of new therapeutic strategies. Full article

Spinal muscular atrophy (SMA) is a severe neuromuscular disorder that is caused by mutations in the survival motor neuron 1 (SMN1) gene, hindering the production of functional survival motor neuron (SMN) proteins. Antisense oligonucleotides (ASOs), a versatile DNA-like drug, are adept at binding to target RNA to prevent translation or promote alternative splicing. Nusinersen is an FDA-approved ASO for the treatment of SMA. It effectively promotes alternative splicing in pre-mRNA transcribed from the SMN2 gene, an analog of the SMN1 gene, to produce a greater amount of full-length SMN protein, to compensate for the loss of functional protein translated from SMN1. Despite its efficacy in ameliorating SMA symptoms, the cellular uptake of these ASOs is suboptimal, and their inability to penetrate the CNS necessitates invasive lumbar punctures. Cell-penetrating peptides (CPPs), which can be conjugated to ASOs, represent a promising approach to improve the efficiency of these treatments for SMA and have the potential to transverse the blood–brain barrier to circumvent the need for intrusive intrathecal injections and their associated adverse effects. This review provides a comprehensive analysis of ASO therapies, their application for the treatment of SMA, and the encouraging potential of CPPs as delivery systems to improve ASO uptake and overall efficiency. Full article

Soft robotics is a hot scientific topic in areas such as medicine and medical care, implantology, haptic technologies, and the design of various flexible structures. Integrated actuators (DEAP and MRE) are characterized by special functionality and a wider range of operations than when used individually. Such actuators can later be controlled with high voltages ranging from several to a dozen or so kV. Unfortunately, the production process of integrated actuators is multi-stage and therefore more complicated. Thus, at the stage of prototyping, microscopic errors often occur that cannot be detected using simple measurement methods. The result of such errors is actuator damage at the testing stage or in subsequent application. Unfortunately, due to high voltages, actuator damage usually leads to it catching fire, which is potentially dangerous. This work presents an approach that enables the prediction of actuator damage at the testing stage. The results of modeling damaged actuators, a modified safe testing method, and a complete supervising system for testing the actuator with protection are shown. The work is also enriched with a set of data from the analyzed damage to DEAP and MRE actuators, which may prove useful in other research on the actuators of soft robotics. Full article

The crack detection method based on image processing has been a new achievement in the field of civil engineering inspection in recent years. Column piers are generally used in bridge structures. When a digital camera collects cracks on the pier surface, the loss of crack dimension information leads to errors in crack detection results. In this paper, an image stitching method based on Speed-Up Robust Features (SURFs) is adopted to stitch the surface crack images captured from different angles into a complete crack image to improve the accuracy of the crack detection method based on image processing in curved structures. Based on the proposed method, simulated crack tests of vertical, inclined, and transverse cracks on five different structural surfaces were conducted. The results showed that the influence of structural curvature on the measurement results of vertical cracks is very small and can be ignored. Nevertheless, the loss of depth information at both ends of curved cracks will lead to errors in crack measurement outcomes, and the factors that affect the precision of crack detection include the curvature of the surface and the length of the crack. Compared with inclined cracks, the structural curvature significantly influences the measurement results of transverse cracks, especially the length measurement results of transverse cracks. The image stitching method can effectively reduce the errors caused by the structural curved surface, and the stitching effect of three images is better than that of two images. Full article

The electric vehicle (EV) industry challenges battery joining technologies by requiring higher energy density both by mass and volume. Improving the energy density via new battery chemistry would be the holy grail but is seriously hindered and progresses slowly. In the meantime, alternative ways, such as implementing more efficient cell packaging by minimising the electrical resistance of joints, are of primary focus. In this paper, we discuss the challenges associated with the electrical characterisation of laser-soldered joints in general, and the minimisation of their resistive losses, in particular. In order to assess the impact of joint resistance on the overall resistance of the sample, the alteration in resistance was monitored as a function of voltage probe distance and modelled by finite element simulation. The experimental measurements showed two different regimes: one far from the joint area and another in its vicinity and within the joint cross-section. The presented results confirm the importance of the thickness of the filler material, the effective and total soldered area, and the area and position of the voids within the total soldered area in determining the electrical resistance of joints. Full article

Background: Abdominoperineal resection (APR)—the standard surgical procedure for low-lying rectal cancer (LRC)—leads to significant perineal defects, posing considerable reconstruction challenges that, in selected cases, necessitate the use of plastic surgery techniques (flaps). Purpose: To develop valuable decision algorithms for choosing the appropriate surgical plan for the reconstruction of perineal defects. Methods: Our study included 245 LRC cases treated using APR. Guided by the few available publications in the field, we have designed several personalized decisional algorithms for managing perineal defects considering the following factors: preoperative radiotherapy, intraoperative position, surgical technique, perineal defect volume, and quality of tissues and perforators. The algorithms have been improved continuously during the entire period of our study based on the immediate and remote outcomes. Results: In 239 patients following APR, the direct closing procedure was performed versus 6 cases in which we used various types of flaps for perineal reconstruction. Perineal incisional hernia occurred in 12 patients (5.02%) with direct perineal wound closure versus in none of those reconstructed using flaps. Conclusion: The reduced rate of postoperative complications suggests the efficiency of the proposed decisional algorithms; however, more extended studies are required to categorize them as evidence-based management guide tools. Full article

This study investigated how the COVID-19 pandemic impacted earnings management practices within both public and private firms in Korea. Amid active government efforts and policies to overcome the pandemic crisis, we anticipate that the earnings management of public sector managers, prioritizing public benefit as their key sustainability objective, will distinctly differ from those of private sector managers, who are influenced by a different set of pressures and incentives. Empirical analysis revealed a notable decrease in earnings management in the public sector post-COVID-19, with no significant change in the private sector. Our study distinguishes how public and private firms react to identical economic crises, deepening our insight into the ways different organizations handle financial reporting amid government intervention and economic stress. Such differentiation not only broadens our comprehension of strategies for managing earnings but also offers vital perspectives on the dynamics among corporate governance, regulatory environments, and sustainability. Full article

Mycobacterium avium subspecies paratuberculosis (MAP) infection leads to chronic, persistent granulomatous enteritis, causing prolonged diarrhoea and emaciation. The disease is managed using medications such as antibiotics, live vaccines, mycobacteriophage therapies and other treatments; however, a notable proportion of affected animals do not show improvement with this approach. We hypothesise that immunoinhibitory receptors TIM-3 (T cell immunoglobulin mucin protein-3) and PD-1 (Programmed death receptor 1) may be upregulated on Peripheral blood mononuclear cells (PBMCs) of MAP-seropositive bovines, potentially contributing to immune exhaustion. Samples (blood and faeces) were collected from 32 diarrhoeic bovines suspected of MAP infection; eight apparently healthy buffaloes from the dairy farm at Hisar, Haryana and from 14 cows (suffering from chronic diarrhoea, weakness and emaciation) housed in stray cattle shed. MAP infection was estimated using indigenous ELISA (i-ELISA), faecal IS900 PCR, culture and acid-fast staining. TIM-3 and PD-1 gene expression on PBMCs were determined using qRT-PCR. TIM3 expression was relatively higher (~400-fold, 330-fold, 112-fold, 65-fold and 16-fold) in 5 chronically diarrhoeic PBMCs samples (MAP-seropositive), and higher PD-1 expression (around ~7-fold, 1.75-fold, 2.5-fold, 7.6-fold) was recorded in 4 diarrhoeic MAP-seropositive animals, compared to apparently healthy and other MAP-seronegative diarrhoeic animals. High co-expression of TIM-3 and PD-1 levels was also recorded in chronically diarrhoeic, emaciated stray cattle. Understanding immune responses in field conditions might aid in the therapeutic management of paratuberculosis. Full article

Levosimendan’s calcium sensitizing effects in heart muscle cells are well established; yet, its potential impact on skeletal muscle cells has not been evidently determined. Despite controversial results, levosimendan is still expected to interact with skeletal muscle through off-target sites (further than troponin C). Adding to this debate, we investigated levosimendan’s acute impact on fast-twitch skeletal muscle biomechanics in a length-dependent activation study by submersing single muscle fibres in a levosimendan-supplemented solution. We employed our MyoRobot technology to investigate the calcium sensitivity of skinned single muscle fibres alongside their stress–strain response in the presence or absence of levosimendan (100 µM). While control data are in agreement with the theory of length-dependent activation, levosimendan appears to shift the onset of the ‘descending limb’ of active force generation to longer sarcomere lengths without notably improving myofibrillar calcium sensitivity. Passive stretches in the presence of levosimendan yielded over twice the amount of enlarged restoration stress and Young’s modulus in comparison to control single fibres. Both effects have not been described before and may point towards potential off-target sites of levosimendan. Full article

This study is based on a sample of 30 Sinitic languages spoken in the Hunan Province. Its first objective is to explore the types of dative markers, comparing the form of the dative with allative, passive, benefactive, and differential object markers in these languages. Five patterns are identified: (I) DAT = ALL (II) DAT = GIVE = OM ≠ PASS; (III) DAT = GIVE = OM = PASS; (VI) DAT = GIVE = PASS ≠ OM; (V) DAT = BEN. Then, we reveal three main possible grammaticalization pathways that motivate the five synchronic patterns: (a) Allative > Dative; (b) (TAKE >) GIVE > Dative; (c) Benefactive > Dative. It concerns two distinct developments for the second pathway. Based on the areal distribution of the various types of dative markers, we can observe how the dative markers are developed in Hunan Sinitic languages. Full article

In this study, the chemical composition, repellent, and oviposition deterrent effects of five plant essential oils (EOs) extracted from Lantana camara (Verbenaceae), Schinus terebinthifolia (Anacardiaceae), Callistemon viminalis (Myrtaceae), Helichrysum odoratissimum (Asteraceae), and Hyptis suaveolens (Lamiaceae) were evaluated against Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus. When tested at 33.3 µg/cm², L. camara, S. terebinthifolia, C. viminalis, and H. odoratissimum were effective repellents against Ae. aegypti (89%, 91%, 90%, and 51% repellency, respectively), but they were less repellent against An. gambiae (66%, 86%, 59%, and 49% repellency, respectively). Interestingly, L. camara, S. terebinthifolia, C. viminalis, and H. odoratissimum exhibited 100% repellency against Cx. quinquefasciatus at 33.3 μg/cm². In time-span bioassays performed at 333 μg/cm², the EO of L. camara exhibited 100% repellence against Ae. aegypti and An. gambiae for up to 15 min and against Cx. quinquefasciatus for 75 min. The oviposition bioassays revealed that L. camara exhibited the highest activity, showing 85%, 59%, and 89% oviposition deterrence against Ae. aegypti, An. gambiae, and Cx. quinquefasciatus, respectively. The major compounds of L. camara, S. terebinthifolia, and C. viminalis were trans-β-caryophyllene (16.7%), α-pinene (15.5%), and 1,8-cineole (38.1%), respectively. In conclusion, the L. camara and S. terebinthifolia EOs have the potential to be natural mosquito repellents. Full article

Nowadays, technology is increasingly being adopted in different kinds of businesses to process, store, and share sensitive information in digital environments that include enormous numbers of users. However, this has also increased the likelihood of cyberattacks and misuse of information, potentially causing severe damage. One promising technology, which can provide the required security services with an improved level of efficiency, is blockchain. This research explores the use of Ethereum blockchain and smart contracts to create a secure and efficient quality assurance system (QAS) for academic programs. By utilizing blockchain and smart contracts, the proposed approach improves the integrity and reliability of sensitive information processed by the QAS, promotes transparency and governance, and reduces the time and effort required for quality operations. The current approach uses an additional access control layer to further enhance user privacy. Smart contracts automate various quality transactions and saves time and resources, and hence increases the efficiency of the QAS. The interplanetary file system (IPFS) is used to address the challenge of size limitations in blockchain. Additionally, this research investigates the use of various cryptographic schemes to provide robust security services at the application layer. The experimental results showed that the use of a hybrid cryptosystem relying on an Elliptic curve digital signature and AES encryption (AES_ECCDSA) outperforms other counterparts’ cryptosystems using an RSA digital signature and AES encryption (AES_RSADSA) and Elliptic Curve Integrated Encryption Scheme (ECIES) in terms of speed. The performance results showed that AES_ECCDSA consumes 188 ms to perform the required cryptographic operations for a standard-quality document with a size of 8088 KB, compared to the 231 ms and 739 ms consumed by the AES_RSADSA and ECIES schemes, respectively. This study presents a prototype implementation of the blockchain-based QAS, which outlines the processing model and system requirements for key QAS processes. It has been found that the cost and time required for blockchain operations vary depending on the size of the input data—a larger data size requires more time and costs more to process. The results of the current study showed that the time delay for blockchain transactions ranges from 15 to 120 s, while the cost ranges from USD 50 to USD 400. This research provides evidence that blockchain and smart contract technologies have the potential to create a secure, efficient, and trustworthy QAS environment for academic programs. Full article