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A New Versatile Protocol for the Synthesis of Indazolophthalazinetriones

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Abstract

Potassium hydrogen sulfate (KHSO4) and trifluoromethanesulfonic acid (CF3SO3H) were separately used as efficient catalysts for the one-pot three-component synthesis of a series of indazolophthalazinetriones from various aldehydes, dimedone, and 2,3-dihydrophthalazine-1,4-dione at 80°C under solvent-free conditions in good to excellent yields. It was found that trifluoromethanesulfonic acid is a more efficient catalyst than potassium hydrogen sulfate since CF3SO3H is a stronger acid than KHSO4, and the corresponding intermediate will probably be formed at a higher rate and be more stable.

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Funding

The authors are grateful to the Bu-Ali Sina University, Hamedan, Iran, for the financial support of this work.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 6517838683, Hamedan, Iran

    D. Habibi, S. Shojaei & S. Heydari

  2. Department of Research and Development, Faran Shimi Pharmaceutical Company, Tuyserkan, Iran

    S. Heydari

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  1. D. Habibi
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Correspondence to D. Habibi.

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Habibi, D., Shojaei, S. & Heydari, S. A New Versatile Protocol for the Synthesis of Indazolophthalazinetriones. Russ J Org Chem 57, 85–90 (2021). https://doi.org/10.1134/S1070428021010127

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