Water helps cells to migrate

Latest research

1. 1. Chromosomes and Gene Expression

   The role of RNA in the maintenance of chromatin domains as revealed by antibody-mediated proximity labelling coupled to mass spectrometry

   Rupam Choudhury, Anuroop Venkateswaran Venkatasubramani ... Axel Imhof

   Proximity biotinylation of the Drosophila centromere suggests a role of RNA helicases, centromeric transcripts, and centromeric R-loops for centromere function.
2. 1. Structural Biology and Molecular Biophysics

   Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO₂

   Deborah H Brotherton, Sarbjit Nijjar ... Alexander David Cameron

   The mutation of Lys125 in connexin26 to glutamate, a carbamylation mimetic, pushes the equilibrium of the gap junction channel seen in cryo-EM towards a more closed conformation.
3. 1. Cell Biology
   2. Computational and Systems Biology

   Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokinces on muscle regeneration

   Megan Haase, Tien Comlekoglu ... Silvia S Blemker

   A computational model of skeletal muscle regeneration reveals complex interplay of cytokines, angiogenesis, and cell behaviors, predicting that synergistic cytokine perturbations enhance skeletal muscle regeneration beyond individual cytokine interventions.
4. 1. Developmental Biology

   Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

   Xianwei Chen, Yanfeng Li ... Zhenguo Wu

   Styxl2, a sarcomeric muscle-specific pseudophosphatase in vertebrates, functions in sarcomere assembly by promoting protein degradation of non-muscle myosin IIs.
5. 1. Neuroscience

   The archerfish uses motor adaptation in shooting to correct for changing physical conditions

   Svetlana Volotsky, Opher Donchin, Ronen Segev

   The archerfish adapts with egocentric reference frame to correct for different conditions during shot above water level.
6. 1. Neuroscience

   Glutamatergic supramammillary nucleus neurons respond to threatening stressors and promote active coping

   Abraham Escobedo, Salli-Ann Holloway ... Aaron J Norris

   Activation of a population of glutamatergic neurons in supramammillary nucleus enhances active coping behaviors in response to threats, offering new insights for therapeutic strategies against anxiety and mood disorders.
7. 1. Epidemiology and Global Health

   The impact of surgery and oncological treatment on risk of type 2 diabetes onset in patients with colorectal cancer: nationwide cohort study in Denmark

   Caroline Krag, Maria Saur Svane ... Tinne Laurberg

   Treatment of colorectal cancer with colonic resection compared with rectal resection results in sligthly increased T2D risk, whereas chemotherapy treatment does not impact risk of developing T2D.
8. 1. Neuroscience

   Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses

   Satyajit Mahapatra, Tomoyuki Takahashi

   Physiologically, vesicle replenishment at the fast calyx synapse requires both fast-endocytosis and scaffold machinery to support rapid neurotransmission, whereas at the slow hippocampal CA1 synapse only endocytosis is necessary.
9. 1. Neuroscience

   Emergence of brain-like mirror-symmetric viewpoint tuning in convolutional neural networks

   Amirhossein Farzmahdi, Wilbert Zarco ... Tal Golan

   Mirror-symmetric view tuning in the macaque AL face patch can be explained by the spatial pooling of learned reflection-equivariant representations.
10. 1. Epidemiology and Global Health
    2. Computational and Systems Biology

    Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers

    Javier I. Ottaviani, Virag Sagi-Kiss ... Gunter G. C. Kuhnle