Food marketing targeting children influences their choices and dietary habits, and mainly promotes food high in fat, sugar, and salt as well as ultra-processed food. The aim of this study was to assess the nutritional quality of food and beverages marketed to children over the age of 3 and available on the Swiss market. Products with at least one marketing technique targeting children on the packaging were selected from five food store chains. Three criteria to assess nutritional quality were used: (1) nutritional composition (using the Nutri-Score), (2) degree of processing (NOVA classification), and (3) compliance with the World Health Organization (WHO) Nutrient Profile Model (NPM). A total of 735 products were found and analyzed. The most common marketing techniques used were childish names/fonts (46.9%), special characters (39.6%), and children’s drawings (31.3%). Most products had a Nutri-Score of D or E (58.0%) and were ultra-processed (91.8%). Only 10.2% of products displayed the Nutri-Score. The least processed products generally had a better Nutri-Score (p < 0.001). Most products (92.8%) did not meet the criteria of the WHO NPM. Products that met the WHO NPM criteria, organic products, and products with a nutritional claim generally had a better Nutri-Score and were less processed (p_s < 0.05). Pre-packaged foods and beverages marketed to children in the Swiss market were mostly of poor nutritional quality. Public health measures should be adopted to improve the nutritional quality of foods marketed to children in Switzerland and restrict the marketing of unhealthy foods to children. Full article

Autism spectrum disorder (ASD) is a neurodevelopmental disorder identified by impairments in common social interactions and repetitive behaviors. In ASD patients, substantial morphological alterations have been observed in the hippocampus, which represents an important region for the development of social skills. Melatonin, commonly found in many foods and plants, is also produced by the pineal gland. This indolamine, known to regulate the circadian rhythm, shows antioxidant and anti-inflammatory properties. We therefore hypothesized that melatonin may reduce oxidative stress and inflammation in the hippocampus of ASD patients. We explored our hypothesis using the BTBR mouse, a well-regarded murine transgenic model for ASD. Immediately after weaning, male BTBR and C57BL/6 mice underwent an 8-week treatment with melatonin or vehicle. Later, through immunohistochemistry and the immunoblotting analysis of the hippocampus, we evaluated the overall expression and cellular localization of Nrf2 and SOD1, two enzymes involved in the oxidative stress response. Similarly, we evaluated NLRP3 and NFkB, two mediators of inflammation, and GAD67, an enzyme responsible for the synthesis of GABA. Ultimately, we addressed melatonin’s potential to regulate iron metabolism through a DAB-enhanced Perls reaction assay. Results showed melatonin’s potential for modulating the analyzed markers in BTBR mice, suggesting a potential neuroprotective effect in ASD patients. Full article

Machine learning deals with creating algorithms capable of learning from the provided data. These systems have a wide range of applications and can also be a valuable tool for scientific research, which in recent years has been focused on finding new diagnostic techniques for particle accelerator beams. In this context, SPARC_LAB is a facility located at the Frascati National Laboratories of INFN, where the progress of beam diagnostics is one of the main developments of the entire project. With this in mind, we aim to present the design of two neural networks aimed at predicting the spot size of the electron beam of the plasma-based accelerator at SPARC_LAB, which powers an undulator for the generation of an X-ray free electron laser (XFEL). Data-driven algorithms use two different data preprocessing techniques, namely an autoencoder neural network and PCA. With both approaches, the predicted measurements can be obtained with an acceptable margin of error and most importantly without activating the accelerator, thus saving time, even compared to a simulator that can produce the same result but much more slowly. The goal is to lay the groundwork for creating a digital twin of linac and conducting virtualized diagnostics using an innovative approach. Full article

Renal amyloidosis is a set of complex disorders characterized by the deposition of amyloid proteins in the kidneys, which causes gradual organ damage and potential kidney failure. Recent developments in diagnostic methods, particularly mass spectrometry and proteome profiling, have greatly improved the accuracy of amyloid typing, which is critical for disease management. These technologies provide extensive insights into the specific proteins involved, allowing for more targeted treatment approaches and better patient results. Despite these advances, problems remain, owing to the heterogeneous composition of amyloid proteins and the varying efficacy of treatments based on amyloid type. Access to sophisticated diagnostics and therapy varies greatly, highlighting the global difference in renal amyloidosis management. Future research is needed to investigate next-generation sequencing and gene-editing technologies, like clustered regularly interspaced short palindromic repeats (CRISPR), which promise more profound insights into the genetic basis of amyloidosis. Full article

The aim of this study was to assess the use of antibiotics in hospitals and different departments over 14 years (2006–2019) and the impact of various national activities related to this, including national audits of the use of antibiotics for systemic use. The consumption of antibiotics for systemic use (J01) from all Slovenian hospitals (n = 29) and five departments (internal medicine, surgery, ICU (medicine, surgery), paediatrics and gynaecology/obstetrics) was collected. Total hospital consumption was expressed as the number of defined daily doses (DDDs) per 1000 inhabitants per day (DID), the number of DDDs/100 bed days and the number of DDDs/100 admissions. Over 14 years, J01 hospital consumption increased by 13.8%, expressed in DDDs/100 bed days (p = 0.002). In 2019, compared to 2006, the consumption of J01, expressed in DDD/100 bed days, increased from 19.9% to 33.1% in all departments, except intensive care units. J01 consumption expressed in DDD/100 admissions increased by 7.0% to 39.4% in all but paediatric wards (where it decreased by 12.7%). In all years, we observed large variations in the consumption of antibiotics in departments of the same type. The effectiveness of audit interventions aimed at optimizing antibiotic consumption exhibited notable variation across hospitals, with specialized facilities generally demonstrating superior outcomes compared to general hospitals. Full article

Urban spatial segregation in Santiago de Chile, a prevalent feature of Latin American cities, underscores socioeconomic disparities and shapes the city’s socio-spatial dynamics. This segregation, driven by land prices and private ownership, has pushed disadvantaged groups to the periphery and limited their access to desirable areas reserved for wealthier segments of society. Quebrada Macul Park, situated within this segregated urban landscape, serves as an emblematic case that challenges and expands the classical definition of urban segregation. It exemplifies the complex negotiations over space utilization among social groups, defined by socioeconomic, generational, and interest-based differences. This study employs micro-segregation studies in a broad sense, both as a conceptual framework and as a methodological tool to analyze these dynamics. Through qualitative methodologies, including six in-depth interviews with diverse stakeholders (social and ecological activists, longtime residents, and park employees) and five participant observations, the research investigates the varied uses and meanings attributed to the park. The findings reveal that the park’s evolution from a space frequented by low-income dwellers to a diverse metropolitan park has sparked debates over its public versus private character, mirroring the power struggles among distinct social factions. The park serves as a profound identity marker for its historical inhabitants, who initially fought for the right to use it and today experience nostalgia due to its widespread popularity. Meanwhile, the struggle to establish the park as a public space challenges the city’s segregation dynamics and might promote social cohesion within urban natural environments. Full article

(1) Background: Geriatric patients are at high risk of complications of Coronavirus disease-2019 (COVID-19) and are good candidates for antiviral drugs. (2) Methods: A retrospective study of electronic health records (EHRs) aiming to describe antiviral (nirmatrelvir and ritonavir (nirmatrelvir/r) or remdesivir) use, drug–drug interactions (DDIs) and adverse drug reactions (ADRs) in elderly patients (75 and over), hospitalized with mild-to-moderate COVID-19 between July 2022 and June 2023. (3) Results: Out of 491 patients (mean age: 86.9 years), 180 (36.7%) received nirmatrelvir/r, 78 (15.9%) received remdesivir, and 233 (47.4%) received no antiviral therapy. No association was found between the choice of antiviral and the demographic or medical data. No serious ADR was observed. Nirmatrelvir/r dosage adjustment was inadequate in 65% of patients with renal impairment. In total, 128 patients (71%) on nirmatrelvir/r had potential pharmacokinetic DDIs, with 43 resulting in a possibly related ADR. In the remdesivir group, pharmacodynamic DDIs were more frequent, with QTc prolongation risk in 56 patients (72%). Only 20 patients underwent follow-up ECG, revealing QTc prolongation in 4. (4) Conclusions: There is an underutilization of antivirals despite their justified indications. Nirmatrelvir/r dosage was rarely adjusted to renal function. Dose adjustments and closer monitoring are needed due to the high risk of drug interactions. Full article

Being a bio-sourced and biodegradable polymer, polylactic acid (PLA) has been considered as one of the most promising substitutes for petroleum-based plastics. However, its wide application is greatly limited by its very poor ductility, which has driven PLA-toughening modifications to be a topic of increasing research interest in the past decade. Toughening enhancement is achieved often at the cost of a large sacrifice in strength, with the toughness–strength trade-off having remained as one of the main bottlenecks of PLA modification. In the present study, a bio-elastomeric material of epoxidized soybean oil (ESO) crosslinked with sebacic acid (SA) and enhanced by graphene oxide (GO) nanoparticles (NPs) was employed to toughen PLA with the purpose of simultaneously preserving strength and achieving additional functions. The even dispersion of GO NPs in ESO was aided by ultrasonication and guaranteed during the following ESO-SA crosslinking with GO participating in the carboxyl–epoxy reaction with both ESO and SA, resulting in a nanoparticle-enhanced and dynamically crosslinked elastomer (GESO) via a β-hydroxy ester. GESO was then melt-blended with PLA, with the interfacial reaction between ESO and PLA offering good compatibility. The blend morphology, and thermal and mechanical properties, etc., were evaluated and GESO was found to significantly toughen PLA while preserving its strength, with the GO loading optimized at ~0.67 wt%, which gave an elongation at break of ~274.5% and impact strength of ~10.2 kJ/m², being 31 times and 2.5 times higher than pure PLA, respectively. Moreover, thanks to the presence of dynamic crosslinks and GO NPs, the PLA-GESO blends exhibited excellent shape memory effect and antistatic properties. Full article

Background/Objectives: The minimally invasive approach through left mini-thoracotomy is a promising alternative to the median sternotomy for coronary artery bypass. The aim of this study was to compare the short-term outcomes of patients undergoing minimally invasive coronary artery bypass (MIDCAB) with off-pump coronary artery bypass through sternotomy (OPCAB) for single-vessel disease. Methods: From January 2017 to February 2023, 377 consecutive patients aged above 18 years undergoing off-pump bypass of the left anterior descending artery (LAD) with left internal thoracic artery underwent OPCAB. Propensity score matching was then applied. Primary endpoints were in-hospital mortality and 30-day mortality. Results: Prior to matching, 30-day mortality occurred in 2 (0.7%) patients in the MIDCAB group vs. 1 (1%) patient in the OPCAP group (p = 1). Transfusion of red blood cells (RBC) was required in 9.4% and 29% of patients within the MIDCAB and the OPCAB groups, respectively (p < 0.001). Median intensive care stay (ICU) was 1 [1–2] day in the MIDCAB group, vs. 2 [1–3] in the OPCAB (p < 0.001). In the matched cohort, 10% of MIDCAB patients received RBCs vs. 27.5% of OPCAB patients (p = 0.006). Median ICU stay was significantly lower in the MIDCAB group, 1 [1–2] vs. 2 [1–3] days. Conclusions: MIDCAB is as safe and effective as OPCAB for single coronary artery bypass of the LAD with the LITA in select patients. It is associated with a decreased ICU stay and lower transfusion rates when compared with OPCAB. Full article

This paper describes the design, fabrication, integration, characterization, and demonstration of a novel flexible double-sided curvature sensor array for use in soft robotics. The paper explores the performance and potential applications of a piezoresistive sensor array consisting of four gold strain gauges on a flexible polyimide (PI) substrate arranged in a Wheatstone bridge configuration. Multiple sensor strips were arranged like the fingers of a hand. Integrating Shape Memory Alloy (SMA) foils alongside the fingers was explored to mimic a human hand-gripping motion controlled with temperature, while curvature sensor array strips measure the resulting finger shapes. Moreover, object sensing in a flexible granular material gripper was demonstrated. The sensors were embedded within Polydimethylsiloxane (PDMS) to enhance their tactile feel and adhesive properties. The findings of this study are promising for future applications, particularly in robotics and prosthetics, as the ability to accurately mimic human hand movements and reconstruct sensor surfaces paves the way for robotic hand functionality. Full article

With the challenge posed by global warming, accurately estimating and managing carbon emissions becomes a key step for businesses, especially power generation companies, to reduce their environmental impact. Optuna–LightGBM–XGBoost, a novel power and carbon emission relationship model that aims to improve the efficiency of carbon emission monitoring and estimation for power generation companies, is proposed in this paper. Deeply exploring the intrinsic link between power production data and carbon emissions, this model paves a new path for “measuring carbon through electricity”, in contrast to the emission factor method commonly used in China. Unit data from power generation companies are processed into structured tabular data, and a parallel processing framework is constructed with LightGBM and XGBoost, and optimized with the Optuna algorithm. The multilayer perceptron (MLP) is used to fuse features to enhance prediction accuracy by capturing characters that the individual models cannot detect. Simulation results show that Optuna–LightGBM–XGBoost can achieve better performance compared to existing methods. The mean absolute error (MAE), mean squared error (MSE), mean absolute percentage error (MAPE), and coefficient of determination (R²) of the model are 0.652, 0.939, 0.136, and 0.994, respectively. This not only helps governments and enterprises to develop more scientific and reasonable emission reduction strategies and policies, but also lays a solid foundation for achieving global carbon neutrality goals. Full article

Experimental measurement and numerical simulations were carried out for investigating the impact loading behavior of platform decks under regular and irregular wave actions. In the numerical simulation section, a full-scale numerical wave tank was established using STAR-CCM+ software. A decreased tendency can be observed for an increased relative length of platform when the incident wave length is double the deck length. The increased deck height can also decrease impact loading on the platform, which is due to the platform being far away from the incident wave. Impact loading on the deck decreases with the increase in inclination angle, which can be explained by the deck bottom being directly exposed to the incident wave at negative inclination angles. Finally, the variation tendency of impact loading on platform decks under irregular wave actions is similar to that under regular wave actions, including the averaged values and significant values. Full article

Thailand’s rapid population aging and reliance on family-based long-term care requires research into disparities in family caregiver burden. Since the type of residence matters to the caregiving outcome, this research aimed to examine the difference in caregiver burden between residents of private housing estates and traditional village communities. This cross-sectional study was conducted with 1276 family caregivers of community-dwelling Thai older adults, in Chiang Mai province, Thailand. The caregiver burden was examined using the Caregiver Burden Inventory (CBI), and the care recipients’ dependency status was examined using Barthel’s Activity of Daily Living (ADL). Descriptive analysis, multivariate analysis of variance test, and multiple logistic regression analysis were performed. Family caregivers living in a traditional village community were 1.607 times more likely to experience emotional burden (adj. OR 1.607, 95% CI: 1.049, 2.462) and 2.743 times more likely to experience overall caregiver burden (adj. OR: 1.163, 95% CI: 1.163, 6.471) compared to those in the private housing estate group. Our findings showed significant differences in caregiver burden based on residential area, contributing with insights to evidence-based policies, interventions, and programs to minimize disparities and promote family caregivers’ health and well-being. Full article

This paper introduces SEISMONOISY, an application designed for monitoring the spatiotemporal characteristic and variability of the seismic noise of an entire seismic network with a quasi-real-time monitoring approach. Actually, we have applied the developed system to monitor 12 seismic networks distributed throughout the Italian territory. These networks include the Rete Sismica Nazionale (RSN) as well as other regional networks with smaller coverage areas. Our noise monitoring system uses the methods of Spectral Power Density (PSD) and Probability Density Function (PDF) applied to 12 h long seismic traces in a 24 h cycle for each station, enabling the extrapolation of noise characteristics at seismic stations after a Seismic Noise Level Index (SNLI), which takes into account the global seismic noise model, is derived. The SNLI value can be used for different applications, including network performance evaluation, the identification of operational problems, site selection for new installations, and for scientific research applications (e.g., volcano monitoring, identification of active seismic sequences, etc.). Additionally, it aids in studying the main noise sources across different frequency bands and changes in the characteristics of background seismic noise over time. Full article

Multi-scale object detection is critically important in complex driving environments within the field of autonomous driving. To enhance the detection accuracy of both small-scale and large-scale targets in complex autonomous driving environments, this paper proposes an improved YOLOv5-AFAM algorithm. Firstly, the Adaptive Fusion Attention Module (AFAM) and Down-sampling Module (DownC) are introduced to increase the detection precision of small targets. Secondly, the Efficient Multi-scale Attention Module (EMA) is incorporated, enabling the model to simultaneously recognize small-scale and large-scale targets. Finally, a Minimum Point Distance IoU-based Loss Function (MPDIou-LOSS) is introduced to improve the accuracy and efficiency of object detection. Experimental validation on the KITTI dataset shows that, compared to the baseline model, the improved algorithm increased precision by 2.4%, recall by 2.6%, mAP50 by 1.5%, and mAP50-90 by an impressive 4.8%. Full article

According to the latest World Health Organization (WHO) report, an estimated 10.6 million people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major concern is the emergence of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains, fueled by the length of anti-TB treatment and HIV comorbidity. Innovative anti-TB agents acting with new modes of action are the only solution to counteract the spread of resistant infections. To escape starvation and survive inside macrophages, Mtb has evolved to become independent of the host by synthesizing its own amino acids. Therefore, targeting amino acid biosynthesis could subvert the ability of the mycobacterium to evade the host immune system, providing innovative avenues for drug discovery. The aim of this review is to give an overview of the most recent progress in the discovery of amino acid biosynthesis inhibitors. Among the hits discovered over the past five years, tryptophan (Trp) inhibitors stand out as the most advanced and have significantly contributed to demonstrating the feasibility of this approach for future TB drug discovery. Future efforts should be directed at prioritizing the chemical optimization of these hits to enrich the TB drug pipeline with high-quality leads. Full article

The main goal of this research was to determine whether there is a correlation between adherence to the Mediterranean diet (assessed by the Mediterranean Diet Serving Score (MDSS)) and parameters indicating thyroid gland activity, such as concentration of thyroid-stimulating hormone (TSH), thyroid hormones (free triiodothyronine (fT3), free thyroxine (fT4)), thyroglobulin (Tg), antibodies to thyroid proteins (thyroglobulin antibodies (TgAb) and thyroid peroxidase antibodies (TPOAb)), and calcitonin (CT) in plasma and serum samples. An additional objective was to investigate whether there are differences in the values of the MDSS among clinical groups (euthyroid individuals, euthyroid individuals with positive TgAb and/or TPOAb, and hypothyroid and hyperthyroid participants). This cross-sectional study included 4620 participants over 18 years of age from the islands of Korčula and Vis, and the mainland city of Split. The MDSS was assessed from a food frequency questionnaire (FFQ). MDSS values were significantly higher in females compared to males and showed a positive association with the age of the participants. There was no significant difference in the MDSS values among the examined clinical groups. In the group of subjects with euthyroidism, a significant positive association was found between fT3 and the MDSS, while in the group of subjects with subclinical hypothyroidism, a significant positive association was observed between the MDSS and both fT3 and fT4. CT levels were also positively associated with the MDSS. Considering the significant positive association of the MDSS and both fT3 and fT4 levels in patients with subclinical hypothyroidism, the results of this study could be used to create guidelines for selecting an appropriate, potentially protective diet for these patients. Full article

People with intellectual disability want friendships and meaningful relationships, and some want intimacy. However, the expression of sexuality is an area where potential freedoms are often limited and restricted compared to their peers. While some relationships and sexuality education programmes do exist for this population, most focus on knowledge acquisition regarding sexuality and sex but lack in their focus on relationships, informed choices and decision-making. The aim of this study was to identify good practices and methods of delivery in relationships and sexuality education for children and young people with intellectual disability. A qualitative design was undertaken. Information about our study was distributed to eight special schools in the UK. Semi-structured interviews and focus groups were employed for data collection. Data from 37 pupils with intellectual disability, 11 parents and 16 healthcare and other professionals were thematically analysed. Following data analysis, three themes emerged: (i) seeking and sharing information; (ii) protecting and keeping safe; and (iii) learning for the future. The findings highlight that pupils are keen to learn about life changes and societal influences and want reliable information. Parents and professionals recognise that children and young people with intellectual disability will develop into adults and may be vulnerable when they leave the security of the school setting. They recognise that children and young people need to know about socialising, puberty, consent and contraception. Evidence-based programmes should be designed with these stakeholders to ensure children and young people with intellectual disability receive developmentally appropriate information to make happy and safe decisions about their relationships. Full article

This in vitro study was carried out to compare the cutting efficiency of diamond grinders on zirconia and resin-based composite materials. Grinders were employed with a special holder for the handpiece to apply a constant load (160 g) for resin-based composite (8 cuts, 40 s each) and zirconia materials (4 cuts, 5 min each; n = 10 for each material and grinder). To assess the efficiency of the grinders, weight measurements of the material were taken before and after the grinding process. Scanning electron micrographs were captured for instrument surfaces before and after testing and for the resulting surface of the materials. In the resin-based composite group, there were significant differences in weight removal between the burs for both the baseline (first cut; p = 0.009) and removal after the eighth cut (p = 0.049). Statistically significant decreases in weight removal compared to the baseline values were noted for the third, fourth, sixth, and seventh steps (p ≤ 0.046). For the zirconia group, significant differences existed in weight removal between the burs for the baseline (first cut; p < 0.001) and removal after the fourth cut (p < 0.001). A significant positive correlation was observed between removal and the number of cuts (Pearson: 0.673; p < 0.001). A statistically significant decrease in removal compared to the respective baseline value was found for the fourth step (p = 0.006). The initial wear removal and durability significantly differed between the grinders used on resin-based composite and zirconia. Achieving comparable weight removal took five times longer when grinding zirconia compared to the resin-based composite. Full article

Battlefield surveillance radar is usually 2-D radar, which cannot realize target three-dimensional localization, leading to poor resolution for the air target in the elevation dimension. Previous researchers have used the Traditional Height Finder Radar (HFR) or multiple 2-D radar networking to estimate the target three-dimensional location. However, all of them face the problems of high cost, poor real-time performance and high requirement of space–time registration. In this paper, Reconfigurable Intelligent Surfaces (RISs) with low cost are introduced into the 2-D radar to realize the target three-dimensional localization. Taking advantage of the wide beam of 2-D radar in the elevation dimension, several Unmanned Aerial Vehicles (UAVs) carrying RISs are set in the receiving beam to form multiple auxiliary measurement channels. In addition, the traditional 2-D radar measurements combined with the auxiliary channel measurements are used to realize the target three-dimensional localization by solving a nonlinear least square problem with a convex optimization method. For the proposed RIS-assisted target three-dimensional localization problem, the Cramer–Rao Lower Bound (CRLB) is derived to measure the target localization accuracy. Simulation results verify the effectiveness of the proposed 3-D localization method, and the influences of the number, the positions and the site errors of the RISs on the localization accuracy are covered. Full article

The reuse of construction materials has been a consistent practice throughout the history of architecture, especially prevalent during periods of transition when it was preferred for its ability to simplify installation and reduce construction costs. This practice was particularly common in late Roman urban contexts, where construction materials, especially ashlar and sculptural elements, were abundant following the abandonment of temples and public buildings. However, there are occasions when the use of spolia, or reused materials, goes beyond simple material recycling. The reuse and display of certain pieces carry complex implications involving symbology, cultural appropriation, or collective memory exercises that convey messages through new buildings. In this paper, we focus on the unique case of Hispanic Christian architectural sculptures that were “recycled” in new buildings during the first centuries of Islamic domination of the Iberian Peninsula, specifically within places of worship. Through a general analysis and review of some examples, we aim to reflect on the motivations and intentionality behind the use of certain sculptural pieces and their placement in new buildings, which is not arbitrary. Full article

Cherry is a fruit which contains elevated amounts of antioxidant compounds, such as anthocyanins, pigments, and vitamins. Furthermore, it possesses high water, sugar, mineral, and indolamine contents. The general objective of this study was to characterise a cherry-based fermented beverage (the ‘sweetheart’ variety) and analyse the effects of its ingestion on (i) circulating serum levels of melatonin and serotonin, (ii) inflammatory response, and iii) serum total antioxidant capacity in rats (Rattus norvegicus). For cherry-based fermented beverage manufacturing, the cherries were washed, the stems and woody endocarps were removed, and ascorbic acid was added (to avoid enzymatic browning). After the homogenisation of the cherry fruit, lactic acid bacteria were inoculated, and the fermentation process was conducted for 36 h. The main bioactive compounds in the cherry beverage were characterised, as well as their total antioxidant capacity. Moreover, an in vivo assay was developed, in which rats ingested the fermented beverage ad libitum for seven days. The inflammatory mediators, the total antioxidant capacity, and the serum levels of melatonin and serotonin were measured. Based on these results, the intake of the cherry-based fermented beverage assayed in this study increased the total antioxidant status of rats, elevated the melatonin and serotonin levels in the serum, and improved the regulation of the inflammatory systemic processes. Full article