The Advanced Encryption Standard (AES) is widely recognized as a robust cryptographic algorithm utilized to protect data integrity and confidentiality. When it comes to lightweight implementations of the algorithm, the literature mainly emphasizes area and power optimization, often overlooking considerations related to performance and security. This paper evaluates two of our previously proposed lightweight AES implementations using both profiled and non-profiled attacks. One is an unprotected implementation, and the other one is a protected version using Domain-Oriented Masking (DOM). The findings of this study indicate that the inclusion of DOM in the design enhances its resistance to attacks at the cost of doubling the area. Full article

Objective: Following a mild traumatic brain injury (mTBI), the most prevalent and profoundly debilitating occurrence is the emergence of an acute and persistent post-traumatic headache (PTH), for which there are presently no approved treatments. A crucial gap in knowledge exists regarding the consequences of an mTBI, which could serve as a foundation for the development of therapeutic approaches. The activation of trigeminal sensory nerve terminals that innervate the calvarial periosteum (CP)—a densely innervated tissue layer covering the calvarial skull—has been implicated in both migraines and PTHs. We have previously shown that trigeminal oxytocin receptors (OTRs) may provide a therapeutic target for PTHs. This study examined the expression of oxytocin receptors on trigeminal nerves innervating the periosteum and whether these receptors might serve as a therapeutic target for PTHs using a direct application of oxytocin to the periosteum in a rodent model of PTH. Methods: We used retrograde tracing and immunohistochemistry to determine if trigeminal ganglion (TG) neurons innervating the periosteum expressed OTRs and/or CGRPs. To model the impact of local inflammation that occurs following an mTBI, we applied chemical inflammatory mediators directly to the CP and assessed for changes in immediate-early gene expression as an indication of neuronal activation. We also determined whether mTBI would lead to expression changes to OTR levels. To determine whether these OTRs could be a viable therapeutic target, we assessed the impact of oxytocin injections into the CP in a mouse model of PTH-induced periorbital allodynia. Results: The results of these experiments demonstrate the following: (1) the cell bodies of CP afferents reside in the TG and express both OTRs and CGRPs; (2) inflammatory chemical stimulation of the periosteum leads to rapid activation of TG neurons (phospho-ERK (p-ERK) expression), (3) mTBI-induced inflammation increased OTR expression compared to the sham group; and (4) administration of oxytocin into the periosteum on day 2 and day 40 blocked cutaneous allodynia for up to one hour post-administration for both acute and persistence phases in the PTH model—an effect that was preventable by the administration of an OTR antagonist. Conclusion: Taken together, our observations suggest that periosteal trigeminal afferents contribute to post-TBI craniofacial pain, and that periosteum tissue can be used as a potential local target for therapeutics such as oxytocin. Full article

Religion in Europe has been undergoing two fundamental changes in the past four decades. As a side effect of secularization, religious fields have been pluralizing. On the other hand, religions themselves have taken a qualitative shift towards lived, material characteristics. Focusing exclusively on the diversification of European religious fields, we are interested in the concept of religious literacy as a tool for competent engagement in contemporary religious plural societies. To better understand the role of public media in fostering religious literacy, we offer an analysis of the public broadcaster’s coverage of smaller religious communities in Slovenia. Focusing particularly on Muslims as the largest religious minority in Slovenia, we provide an analysis of 245 episodes, consisting of 540 items, in the 2015–2020 period. We show that the coverage given to smaller religious communities is unevenly spread amongst the communities, with disproportional airtime given to Christian churches and communities. Furthermore, we pinpoint the key qualitative difference in portrayals of Slovenian Muslims and non-Catholic Christians, explaining how the process of racialized Islamophobia may continue beyond explicit hate speech. In conclusion we set out limitations of our study and provide guidelines for future research. Full article

Environmental factors, such as drought stress, significantly impact maize growth and productivity worldwide. To improve yield and quality, effective strategies for early detection and mitigation of drought stress in maize are essential. This paper presents a detailed analysis of three imaging trials conducted to detect drought stress in maize plants using an existing, custom-developed, low-cost, high-throughput phenotyping platform. A pipeline is proposed for early detection of water stress in maize plants using a Vision Transformer classifier and analysis of distributions of near-infrared (NIR) reflectance from the plants. A classification accuracy of 85% was achieved in one of our trials, using hold-out trials for testing. Suitable regions on the plant that are more sensitive to drought stress were explored, and it was shown that the region surrounding the youngest expanding leaf (YEL) and the stem can be used as a more consistent alternative to analysis involving just the YEL. Experiments in search of an ideal window size showed that small bounding boxes surrounding the YEL and the stem area of the plant perform better in separating drought-stressed and well-watered plants than larger window sizes enclosing most of the plant. The results presented in this work show good separation between well-watered and drought-stressed categories for two out of the three imaging trials, both in terms of classification accuracy from data-driven features as well as through analysis of histograms of NIR reflectance. Full article

The primary research question driving this paper is the following: “What are the schooling experiences of young people who are at risk of or experiencing homelessness?” Through interviews with 28 young people in two cities in Ontario, Canada, the authors identified several common experiences, including the following: lack of available information that could help them cope with their housing difficulties; prejudice and bullying from other students, sometimes stemming from their housing problems but also due to factors such as racialization, gender identity, poverty, and substance use; and individual support from some teachers and support staff, although this was dependent on being in school. They proposed changes to help young people still in school, including the inclusion of non-judgmental information and guidance on dealing with poverty and homelessness in school curricula, educating school staff about the ‘symptoms’ of homelessness to help them identify students at risk, and creating more safe and supportive school environments overall. Full article

Steel structures are susceptible to corrosion due to their exposure to the environment. Currently used non-destructive techniques require inspector involvement. Inaccessibility of the defective part may lead to unnoticed corrosion, allowing the corrosion to propagate and cause catastrophic structural failure over time. Autonomous corrosion detection is essential for mitigating these problems. This study investigated the effect of the type of encoder–decoder neural network and the training strategy that works the best to automate the segmentation of corroded pixels in visual images. Models using pre-trained DesnseNet121 and EfficientNetB7 backbones yielded 96.78% and 98.5% average pixel-level accuracy, respectively. Deeper EffiecientNetB7 performed the worst, with only 33% true-positive values, which was 58% less than ResNet34 and the original UNet. ResNet 34 successfully classified the corroded pixels, with 2.98% false positives, whereas the original UNet predicted 8.24% of the non-corroded pixels as corroded when tested on a specific set of images exclusive to the investigated training dataset. Deep networks were found to be better for transfer learning than full training, and a smaller dataset could be one of the reasons for performance degradation. Both fully trained conventional UNet and ResNet34 models were tested on some external images of different steel structures with different colors and types of corrosion, with the ResNet 34 backbone outperforming conventional UNet. Full article

Although studies have found that job satisfaction has an impact on workers’ physical and mental health, research has generally not focused on the psychological well-being of adult workers and a gender differential analysis has not been conducted. The aim of the current research is to determine the importance of job satisfaction for mental symptoms and well-being among adult working women and men. We also examine gender differences in job satisfaction. A non-probability sample of 1977 Spanish workers (51.6% men and 48.4% women) aged between 36 and 65 years was used in this cross-sectional study. Six questionnaires and self-report scales were used to assess the participants. For both men and women, higher job satisfaction was associated with lower depressive, somatic, anxiety, and social dysfunction symptoms; higher life satisfaction; and greater psychological well-being. Hierarchical multiple regression analyses showed that after controlling for the effects of self-esteem and social support, higher job satisfaction predicted greater life satisfaction, fewer mental symptoms, and greater psychological well-being, although the effect of job satisfaction on psychological well-being was somewhat stronger for men than for women. We conclude that job satisfaction is important for the mental health, psychological well-being, and life satisfaction of adult working women and men. Full article

Young carers face a variety of challenges at school. While schools can be vital places of support, the assistance they receive at school often seems selective and fails to consider the unique life situations of individual students. This paper examines the perspective of multiple actors in the student’s school environment and explores how schools can develop comprehensive, sustainable support systems for young carers—systems that consider and involve as many actors as possible in the student’s school environment. In a secondary analysis of two interview studies, we analyzed how young carers as well as their parents, teachers, and school counsellors perceived the school support the carers received. We then developed an integrated model that incorporates these differing perspectives. The model offers an approach for implementing low-threshold support for young carers within existing school structures in relation to their family situation and outlines conditions that can support both recognized and “invisible” young carers, as well as other students. Full article

African swine fever virus (ASFV) is a double-stranded DNA virus with an envelope. ASFV has almost the largest genome among all DNA viruses, and its mechanisms of immune evasion are complex. Better understanding of the molecular mechanisms of ASFV genes will improve vaccine design. A238L, a nonstructural protein of ASFV, inhibits NF-κB activation by suppressing the HAT activity of p300. Whether A238L also affects the transcriptional activity of IRF3 remains unexplored. Here we first confirmed the ability of A238L to suppress NF-κB-activity in L929 cells. A238L inhibits the expression of proinflammatory cytokine genes. In contrast, A238L increased the phosphorylation levels of TBK1 and IRF3 in three different cell lines. A238L increases the IRF3-driven promoter activity and induces IRF3 nuclear translocation. Furthermore, A238L enhanced innate antiviral immunity in the absence or presence of poly d (A:T) or poly (I:C) stimulation, or herpes simplex virus type 1 (HSV-1) or Sendai virus (SeV) infection. This study reveals a previously unrecognized role of A238L in promoting antiviral immune responses by TBK1-IRF3 pathway activation. Full article

Despite the global importance of solar energy, its variability requires energy storage to balance production during peak and off-peak periods. Moreover, the transport sector is undergoing a global transition from internal combustion engines to electric vehicles. Since vehicles are idle 95% of the time, electric vehicle batteries, when connected to a grid, can effectively regulate intermittent photovoltaics using vehicle-to-grid technology. This conceptual study investigates the feasibility of a nationwide energy infrastructure that relies solely on solar energy, replacing other electricity sources, such as solid fuels, petroleum products, and natural gas, and utilizes electric vehicles as the sole battery energy storage system. This study aims to demonstrate the significant potential and benefits of such collaboration. The theoretical study combines historical data, assumptions, and conditions to build a simulation model that is modelled similarly as in previous conceptual studies of nationwide energy systems based solely on photovoltaics and electric vehicles, referenced in this article. In Slovenia, the total surface size suitable for the installation of photovoltaic systems is estimated to be 280 km². The calculations show that a surface size of 217 km² for photovoltaic systems can produce enough energy to cover Slovenia’s entire energy demand, Slovenia’s final energy consumption. However, simulations comparing photovoltaic production, total energy consumption (electricity, solid fuels, etc.), and the capacity of electric vehicle batteries show that a surface size of more than 500 km² with photovoltaic systems and a 200% share of electric vehicles in the Slovenian vehicle fleet in 2022 will provide satisfactory results. Therefore, for a country like Slovenia, in addition to a solar power plant with a surface size of 280 km², additional renewable energy sources are needed to cover the total energy demand, as well as additional battery energy storage systems in addition to electric vehicles. Full article

In this article, we document the use of hail cannons in Mexico to dispel or suppress heavy rain episodes, a common practice among farmers, without scientific evidence to support its effectiveness. This study uses two rain databases: one compiled from the Global Precipitation Measurement (GPM) mission and the other generated with the implementation of the Weather Research and Forecasting (WRF) model. The aim is to explore the association between heavy rain episodes and hail cannon locations. The analysis includes two geographic features: a pair of coordinates and a 3 km radius area of influence around each hail cannon. This dimension is based on the size and distribution of the heavy rainfall events. This study analyzes four years of half-hourly rain data using the Python ecosystem environment with machine learning libraries. The results show no relationship between the operation of hail cannons and the dissipation or attenuation of heavy rainfall events. However, this study highlights that the significant differences between the GPM and WRF databases in registering heavy rain events may be attributable to their own uncertainty. Despite the unavailability of ground-based observations, the inefficiency of hail cannons in affecting the occurrence of heavy rain events is evident. Overall, this study provides scientific evidence that hail cannons are inefficient in preventing the occurrence of heavy rain episodes. Full article

Temperature is a critical parameter for the GaN HEMT as it sharply impacts the electrical characteristics of the device more than for SiC or Si MOSFETs. Either when designing a power converter or testing a device for reliability and robustness characterizations, it is essential to estimate the junction temperature of the device. For this aim, manufacturers provide compact models to simulate the device in SPICE-based simulators. These models provide the junction temperature, which is considered uniform along the channel. We demonstrate through two-dimensional numerical simulations that this approach is not suitable when the device undergoes high electrothermal stress, such as during short circuit (SC), when the temperature distribution along the channel is strongly not uniform. Based on numerical simulations and experimental measurements on a 650 V/4 A GaN HEMT, we derived a thermal network suitable for SPICE simulations to correctly compute the junction temperature and the SC current, even if not providing information about the possible failure of the device due to the formation of a local hot spot. For this reason, we used a second thermal network to estimate the maximum temperature reached inside the device, whose results are in good agreement with the experimental observed failures. Full article

Active disturbance rejection control (ADRC) is widely used in airborne optoelectronic stabilization platforms due to its minimal reliance on the mathematical model of the controlled object. The extended state observer (ESO) is the core of ADRC, which treats internal parameter variations and external disturbances as total disturbances, observes the disturbances as extended states, and then compensates them into the control loop to eliminate their effects. However, the ESO can only achieve a precise estimation of constant or slowly varying disturbances. When the disturbance is periodically changing, satisfactory results cannot be obtained. In this paper, a generalized high-order extended state observer (GHOESO) is proposed to achieve the precise estimation of known frequency sinusoidal disturbance signals and improve disturbance suppression levels. Through numerical simulations, a traditional ESO and GHOESO are compared in terms of disturbance observation capability and disturbance suppression ability for single and compound disturbances based on our prior knowledge of disturbance frequency. The effectiveness of the proposed GHOESO method is verified. Finally, the algorithm is applied to an airborne optoelectronic stabilization platform for a 1°/1 Hz swing experiment on a space hexapod swing table. The experimental results demonstrate the superiority of the GHOESO proposed in this paper. Full article

The stimulator of interferon genes (STING) plays a significant role in immune defense and protection against tumor proliferation. Many cyclic dinucleotide (CDN) analogues have been reported to regulate its activity, but the dynamic process involved when the ligands activate STING remains unclear. In this work, all-atom molecular dynamics simulations were performed to explore the binding mode between human STING (hSTING) and four cyclic adenosine–inosine monophosphate analogs (cAIMPs), as well as 2′,3′-cGMP-AMP (2′,3′-cGAMP). The results indicate that these cAIMPs adopt a U-shaped configuration within the binding pocket, forming extensive non-covalent interaction networks with hSTING. These interactions play a significant role in augmenting the binding, particularly in interactions with Tyr167, Arg238, Thr263, and Thr267. Additionally, the presence of hydrophobic interactions between the ligand and the receptor further contributes to the overall stability of the binding. In this work, the conformational changes in hSTING upon binding these cAIMPs were also studied and a significant tendency for hSTING to shift from open to closed state was observed after binding some of the cAIMP ligands. Full article

Spinal muscular atrophy is a neuromuscular genetic condition associated with progressive muscle weakness and atrophy. Nusinersen is an antisense oligonucleotide therapy approved for the treatment of 5q spinal muscular atrophy in pediatric and adult patients. The objective of this clinical case series is to describe the efficacy and safety of nusinersen in treating spinal muscular atrophy in 20 pediatric and 18 adult patients across six treatment centers in Kuwait. Functional motor assessments (Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders, Hammersmith Functional Motor Scale Expanded, and Revised Upper Limb Module) were used to assess changes in motor function following nusinersen treatment. The safety assessment involved clinical monitoring of adverse events. The results demonstrate clinically meaningful or considerable improvement in motor performance for nearly all patients, lasting over 4 years in some cases. A total of 70% of patients in the pediatric cohort and 72% of patients in the adult cohort achieved a clinically meaningful improvement in motor function following nusinersen treatment. Additionally, nusinersen was well-tolerated in both cohorts. These findings add to the growing body of evidence relating to the clinical efficacy and safety of nusinersen. Full article

Hepatozoon canis is a protozoan tick-borne parasite infecting domestic and wild canids, including foxes, wolves, and jackals. It is mainly found in dogs but has also been detected in several wild carnivores, including foxes, wolves, and jackals. Host transmission primarily occurs through the ingestion of infected ticks, typically Rhipicephalus sanguineus, with documented instances of transplacental transmission from infected females to cubs. In Serbia, the golden jackal is common throughout the country, and its population has increased in recent years. Previous research has documented the presence of several vector-borne pathogens in the jackal population in Serbia, so we conducted this study to determine the presence, prevalence, and genetic variability of H. canis. Over eleven years (2010–2020), 114 animal samples were collected from 23 localities in Serbia. A total of 90/114 (78.95%) jackals were positive for H. canis, and they came from 22 localities. Among 15 juveniles, almost half (6/15 (40%)) tested positive for H. canis. In addition to the high prevalence, high genetic variability of the pathogen was also found. According to the mutated positions, four sequence types (S4–S7) of H. canis were determined. Based on our earlier research on the grey wolf and on this study, it can be observed that various sequence types of H. canis circulate within wild canid populations in Serbia. The prevalence of H. canis infection in wild carnivores raises significant concerns for wildlife conservation and animal health. Infected animals may act as reservoirs for the disease, posing a potential risk to domestic animals by acting as a source of infection. Full article

The environmental impact of tire wear emissions has become increasingly apparent, and efforts to reduce their impact on the environment are on the rise. To minimise the generation of tire wear, it is essential to consider the influencing factors. However, as it cannot be entirely prevented, measures to reduce immissions are also necessary. This paper summarises possible measures derived from the literature, stakeholder workshops, and the authors’ own conclusions, taking into account the different perspectives: tire, vehicle, road, sustainable mobility and emissions treatment. The presentation of the entry paths of tire wear into the environment and the hotspots of generation can be used to prioritise reduction measures. Measures should be implemented at a political level, technical solutions applied, and awareness raised among the general public. It is evident that reducing tire wear is a complex task that requires a transdisciplinary approach. Full article

In this paper, I address the directionality issue posed by conversion in English through an investigation of category mismatch under VP-ellipsis, a less-studied type of ellipsis mismatch. For example, certain nouns, such as graduate_N and sneeze_N, allow the ellipsis of the VP headed by their morphologically related verbal counterparts, graduate_V and sneeze_V, but not vice versa. I argue that this kind of directional asymmetry, which would be mysterious under a purely semantic identity approach to ellipsis, based on truth-conditional equivalence and mutual entailment, is accounted for in terms of the syntactic identity condition to the effect that the structure of an ellipsis site must be properly contained within the structure of its intended antecedent expression. I will then use this syntactic account of category-mismatched VP-ellipsis as a critical probe into the internal syntax of zero-related N-V pairs and show that both N→V and V→N word-based derivations, in addition to the root-based derivation, must be admitted to account for conversion in English. To the extent that my proposed analysis is on the right track, the kind of asymmetries observed in N-V conversion furnishes an excellent testing ground for an abstract syntactic derivation for these morphologically related word pairs. Full article

Risk management involves thinking about what could happen if someone is exposed to a hazard and the likelihood of this event. The vast majority of standards relating to risk management were written in the context of Occupational Health and Safety, as well as Work Health and Safety with the aim of eliminating all risks. In 2023 Standards, Australia published AS ISO 4980:2023: `Benefit-risk assessment for sport and recreational facilities, activities and equipment’. This standard provides a tool for applying risk management in the context of sport and recreation. AS ISO 4980:2023 is a departure from the traditional view of risk management standards in that it presents a view of risk that is not limited to viewing risk only as negative, but rather balances positive benefits with negative risks within the sport and recreation industry. This standard is also different in that it is based specifically on risk to sport and recreational users and not to employees and employers. The benefit that risk provides in the context of sports and recreational activities is placed on an equal footing with the traditional method of assessing risk. There is an expectation in sports and recreational activities that the user is making an implicit trade-off between the benefits and the inherent risks of the activity, including the potential for harm. This implied expectation is that exposure to risk can be positive. Positive risk and learning from making mistakes are not restricted to childhood development where graduated challenges are used but extend throughout our entire life. The goal of this paper is to draw public attention to the new and different perspective of risk on which AS ISO 4980:2023 is based and to provide an understanding of the concept of benefit–risk assessment. The implications of viewing non-workplace risk in a balanced way are discussed. Full article

The Giant Steerable Science Mirror prototype is being developed to assess the tertiary mirror system of the Thirty Meter Telescope. In this study, a new semi-kinematic coupling design is proposed for the prototype based on three pairs of V-grooves and canoe-like components to allow for high repeatability accuracy under heavy loads. A mathematical model was constructed to estimate the repeatability accuracy using the corresponding measurement results and machining errors. The proposed design was verified by an experiment, and the results were consistent with the mathematical model. Furthermore, the results indicate that the repeatability of the semi-kinematic coupling is sufficient for the requirement. Full article

Most equations and models for photovoltaics are based on the assumption that photovoltaic (PV) devices are flat. Therefore, the actual performance of nonplanar PV devices should be investigated and developed. In this study, two algorithms were developed and defined using vector computations to describe a curved surface based on differential geometry and the interaction with non-uniform solar irradiance (i.e., non-uniform shading distribution in the sky). To validate the computational model, the power output from a commercial curved solar panel for the Toyota Prius 40 series was monitored at four orientation angles and in various climates. Then, these were compared with the calculation results obtained using the developed algorithm. The conventional calculation used for flat PV devices showed an overestimated performance due to ignorance of inherent errors due to curved surfaces. However, the new algorithms matched the measured trends, particularly on clear-sky days. The validated computation method for curved PV devices is advantageous for vehicle-integrated photovoltaic devices and PVs including building-integrated photovoltaics (BIPVs), drones, and agriphotovoltaics. Full article