SFX by Ex Libris Inc.

Title:	Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors
Source:	Acs Medicinal Chemistry Letters [1948-5875] Murphy Benenato, Kerry yr:2014

Basic

Full text

Full text available via American Chemical Society Journals

Year:

Volume:

Issue:

Start Page:

Full text available via PubMed Central

Year:

Volume:

Issue:

Start Page:

Document delivery

Request document via Library/Bibliothek

Users interested in this article also expressed an interest in the following:
description	1.	T,W a l s h, Christopher h. "Prospects for new antibiotics: a molecule-centered perspective." The Journal of Antibiotics 67.1 (2013): 7-16.
description	2.	Mochalkin, I. "Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor." Protein science 17.3 (2008): 450-457.
description	3.	Singh, Sheo B. "Screening strategies for discovery of antibacterial natural products." Expert review of anti-infective therapy 9.8 (2011): 589-613.
description	4.	Gwynn, Michael N. "Challenges of antibacterial discovery revisited." Annals of the New York Academy of Sciences 1213.1 (2010): 5-19.
description	5.	Coggins, BE E. "Refined solution structure of the LpxC-TU-514 complex and pK(a) analysis of an active site histidine: Insights into the mechanism and inhibitor design." Biochemistry 44.4 (2005): 1114-1126.
description	6.	Pucci, Michael J J. "Use of genomics to select antibacterial targets." Biochemical Pharmacology 71.7 (2006): 1066-72.
description	7.	De-Guzman, Andrew N. "The Bacterial Type III Secretion System as a Target for Developing New Antibiotics." Chemical biology & drug design 85.1 (2015): 30-42.
description	8.	Fuhrer, F. "Sequence and length recognition of the C-terminal turnover element of LpxC, the membrane-bound FtsH a soluble substrate of protease." Journal of molecular biology 372.2 (2007): 485-496.
description	9.	Lipton, A. "Residue ionization in LpxC directly observed by Zn-67 NMR spectroscopy." Journal of the American Chemical Society 130.38 (2008): 12671-12679.
description	10.	Jenks, Peter J J. "Metronidazole resistance in Helicobacter pylori." International journal of antimicrobial agents 19.1 (2002): 1-7.
description	11.	Fischbach, Michael A. "Antibiotics for emerging pathogens." Science 325.5944 (2009): 1089-93.
description	12.	Jackman, J E E. "Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site." Biochemistry 40.2 (2001): 514-523.
description	13.	Wright, Gerard D. "New strategies for combating multidrug-resistant bacteria." Trends in molecular medicine 13.6: 260-267.
description	14.	Kirst, H. "Developing new antibacterials through natural product research." Expert opinion on drug discovery 8.5 (2013): 1-93.
description	15.	Mills, Scott D. "When will the genomics investment pay off for antibacterial discovery?" Biochemical Pharmacology 71.7 (2006): 1096-1102.
description	16.	Lewis, K. "Platforms for antibiotic discovery." Nature reviews. Drug discovery 12.5 (2013): 371-387.
description	17.	Overbye, Karen M M. "Antibiotics: where did we go wrong." Drug discovery today 10.1 (2005): 45-52.
description	18.	Payne, David J J. "Drugs for bad bugs: confronting the challenges of antibacterial discovery." Nature reviews. Drug discovery 6.1 (2006): 29-40.
description	19.	Gibbons, S. "Phytochemicals for bacterial resistance - Strengths, weaknesses and opportunities." Planta medica 74.6 (2008): 594-602.
description	20.	Miesel, L. "Genetic strategies for antibacterial drug discovery." Nature reviews. Genetics 4.6 (2003): 442-456.