SFX by Ex Libris Inc.

Title:	Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept
Source:	Journal of Medicinal Chemistry [0022-2623] Kurimoto, Ayumu yr:2010

Basic

Full text

Full text available via American Chemical Society Journals

Year:

Volume:

Issue:

Start Page:

Document delivery

Request document via Library/Bibliothek

Users interested in this article also expressed an interest in the following:
description	1.	Chan, M. "Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates." Bioconjugate chemistry 20.6 (2009): 1194-1200.
description	2.	Lan, T. "Toll-like Receptor 7 Selective Synthetic Oligoribonucleotide Agonists: Synthesis and Structure-Activity Relationship Studies." Journal of medicinal chemistry 52.21 (2009): 6871-6879.
description	3.	Ignacio, Bob J. "Toll-like Receptor Agonist Conjugation: A Chemical Perspective." Bioconjugate chemistry 29.3 (2018): 587-603.
description	4.	Wu, Christina C N C. "Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand." Proceedings of the National Academy of Sciences of the United States of America 104.10 (2007): 3990-5.
description	5.	LaBelle, H. "Self-assembling peptide-based building blocks in medical applications." Advanced drug delivery reviews 110-111.C: 65-79.
description	6.	Kandimalla, Ekambar R. "Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9." Nucleic acids research 41.6 (2013): 3947-61.
description	7.	Shi, Zhengming e. "Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction." ACS medicinal chemistry letters 3.6 (2012): 501-504.
description	8.	Lakshmi, B. "Novel Oligonucleotides Containing Two 3a^2-Ends Complementary to Target mRNA Show Optimal Gene-Silencing Activity." Journal of medicinal chemistry 54.8 (2011): 3027-3036.
description	9.	Khan, S. "Chirality of TLR-2 ligand Pam(3)CysSK(4) in fully synthetic peptide conjugates critically influences the induction of specific CD8(+) T-cells." Molecular immunology 46.6 (2009): 1084-91.
description	10.	Dong Yu et al;, D. "Modifications Incorporated in CpG Motifs of Oligodeoxynucleotides Lead to Antagonist Activity of Toll-like Receptors 7 and 9." Journal of medicinal chemistry 52.16 (2009): 5108-5114.
description	11.	O'Neill, L. A. J., Bryant, C. E., Doyle, S. L.;, L. "Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer." Pharmacological reviews 61.2 (2009): 177-197.
description	12.	Mather, S. "Molecular Imaging with Bioconjugates in Mouse Models of Cancer." Bioconjugate chemistry 20.4 (2008): 631-43.
description	13.	Jin, Jie-Oh S. "Structures of the Toll-like Receptor Family and Its Ligand Complexes." Immunity 29.2 (2008): 182-191.
description	14.	Ebensen, Carlos A A. "Intranasal vaccination with SfbI or M protein-derived peptides conjugated to diphtheria toxoid confers protective immunity against a lethal challenge with Streptococcus pyogenes." Vaccine 24.35-36 (2006): 6088-95.
description	15.	Khan, S. "Distinct uptake mechanisms but similar intracellular processing of two different Toll-like receptor ligand-peptide conjugates in dendritic cells." The Journal of biological chemistry 282.29 (2007): 21145-21159.
description	16.	Oliva, C. R., Swiecki, M. K., Griguer, C. E., Lisa, C.R. R. "The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes." Proceedings of the National Academy of Sciences of the United States of America 105.4 (2008): 1261-1266.
description	17.	Lee, Jie-Oh O. "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex." Nature 458.7242 (2009): 1191-5.
description	18.	Takabayshi, K. "Induction of a homeostatic circuit in lung tissue by microbial compounds." Immunity 24.4 (2006): 475-487.
description	19.	Jost, Marco M M. "Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix metalloproteinase-12: a potential role during arteriogenesis." The FASEB journal 17.13 (2004): 2281-3.
description	20.	Kim, J. "Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide." Cell 87.2 (1996): 343-355.