Conclusion
In healthy subjects ofloxacin pharmacokinetics were found to be linear in the dose range studied (100–400 mg). The terminal half-time was 7.5–8 h and plasma ofloxacin concentrations were still detectable at 16 and 24 h after administration. The ratio of renal ofloxacin clerance: creatinine clearance was 1.35–1.82 and was not significantly different for the three doses. The non-renal clearance of ofloxacin was 40–60 ml·min−1, i.e. 20–30% of the total body clearance.
Food intake delayed the absorption of ofloxacin but did not significantly modify its elimination.
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Leroy, A., Borsa, F., Humbert, G. et al. The pharmacokinetics of ofloxacin in healthy adult male volunteers. Eur J Clin Pharmacol 31, 629–630 (1987). https://doi.org/10.1007/BF00606645
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DOI: https://doi.org/10.1007/BF00606645