Abstract
VITA-1 and VITB-1 are low- and elevated level CRMs, respectively, which were certified for minerals and vitamin contents by National Research Council Canada. The proportions of key ingredients are the same in each formula, and they were prepared in such a way that VITB-1 has twice the amount of minerals and vitamins as VITA-1. The availability of these two matrix-matched CRMs, with different concentrations for all analytes, will not only assist in the validation of procedures and the development of methods for the determination of respective analytes in multivitamins or samples of a similar matrices, but also will be useful for calibration purposes (for the values that are certified). Tablets were individually packaged in trilaminate foil pouches and values presented in the certificate of analysis are expressed on a “as is” basis, with no need for the determination of moisture content on a separate test portion. In addition, certified/reference values are provided per single tablet (mass fraction expressed as both mg/kg and µg/tablet), eliminating the need of a homogenization step prior to analysis. Homogeneity and stability were assessed and included in the final expanded uncertainties of the certified values. Quantity value assignment for both VITA-1 and VITB-1 was based on the use of at least two independent methods, using data generated at NRC and data from external collaborators for confirmation purposes. As a result of this campaign, value assignment was possible for a total of 39 analytes: 24 trace elements and 15 vitamins.
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References
Huskisson E, Maggin S, Ruf M (2007) The role of vitamins and minerals in energy metabolism and well-being. J Int Med Res 35:277–289
Somer E (1995) The essential guide to vitamins and minerals. HarperTorch
Marks J (2012) A guide to the vitamins: their role in health and disease. Medical and technical publishing Co Ltd
Statistics Canada (2015). https://www150.statcan.gc.ca/n1/pub/82-625-x/2017001/article/14831-eng.htm. Accessed 9 Jan 2019
Health Canada (2018). https://health-products.canada.ca/lnhpd-bdpsnh/index-eng.jsp. Accessed 9 Jan 2019
Food and Agriculture Organization of the United Nations and World Health Organization WH (2001). http://www.fao.org/3/a-y2809e.pdf. Accessed 9 Jan 2019
Alshahrani F, Aljohan N (2013) Vitamin D: deficiency, sufficiency and toxicity nutrients. Nutrients 5(9):3605–3616
Farrington K, Miller P, Varghese Z, Baillod RA, Moorhead JF (1981) Vitamin A toxicity and hypercalcaemia in chronic renal failure. BMJ 282:1999–2002
Lam HS, Chow CM, Poon WT, Lai CK, Chan KCA, Wai Lan Yeung JH, Chan AYW, Ng PC (2006) Risk of vitamin A toxicity from candy-like chewable vitamin supplements for children. Pediatrics 118(2):820–824
Penniston K, Tanumihardjo SA (2006) The acute ad chronic toxic effects of Vitamin A. Am J Clin Nutr 83(2):191–201
Bender DA (1999) Non-nutritional uses of vitamin B6. Br J Nutr 81:7–20
Morrison B, Chaudhry V (2012) Medication, toxic, and vitamin-related neuropathies. Peripheral Neropathy 18(1):139–160
LeBlanc ES, Perrin N, Jr JDJ, Ballatore A, Hillier T (2013) JAMA INTERN 173 (7):585–586
Niedzielski P, Rudnicka M, Wachelka M, Kozak L, Rzany M, Wozniak M, Kaskow Z (2016) Selenium species in selenium fortified dietary supplements. Food Chem 90:454–549. https://doi.org/10.1016/j.foodchem.2015.05.125
Unceta N, Astorkie M, Abrego Z, Gómez-Caballero A, Goicolea MA, Barrio RJ (2016) A novel strategy for Cr(III) and Cr(VI) analysis in dietary supplements by speciated isotope dilution mass spectrometry. Talanta 154:255–262
LeBlanc KL, Kawamoto MS, Le P-M, Grinberg P, Nadeau K, Yang L, de Araújo Nogueira AR, Mester Z (2019) Quantitation of selenomethionine in multivitamins and selenium supplements by high performance liquid chromatography inductively-coupled plasma mass spectrometry. Food Anal Methods 12:1316–1326
Korea Research Institute of Standards and Science (2011) Certificate of Analysis, CRM # 108-10-012 Nutritional Supplements Powder for Elemental Analysis 108-10-012
Korea Research Institute of Standards and Science (2016) Certificate of Reference Material CRM # 108-10-019 Multivitamin tablets (for the analysis of organic nutrients) 108-10-019
Sander LC, Sharpless KE, Wise SA, Nelson BC, Phinney KW, Porter BJ, Rimmer CA, Thomas JB, Wood LJ, Yen JH, Duewer DL, Atkinson R, Chen P, Goldschmidt R, Wolf WR, Ho I-P, Betz JM (2011) Certification of vitamins and carotenoids in SRM 3280 multivitamin/multielement tablets. Anal Chem 83(1):99–108
Turk GC, Sharpless KE, Cleveland D, Jongsma C, Mackey EA, Marlow AF, Oflaz R, Paul RL, Sieber JR, Thompson RQ, Wood LJ, Yu LL, Zeisler R, Wise SA, Yen JH, Christopher J, Day RD, Long SE, Greene E, Harnly J, Ho I-P, Bet JM (2013) Certification of elements in and use of Standard Reference Material 3280 multivitamin/multielement tablets. J AOAC Int 96(6):1281–1287
Gonzalez CA, Choquette SJ (2016) Certificate of analysis, Standard Reference material 3280, multivitamin/multiemelent tablets
Yang L, Sturgeon RE (2009) High accuracy and precision isotope dilution mass spectrometry: an application to the determination of Mo in seawater. J Anal At Spectrom 24:1327–1335
Gao Y, Sturgeon RE, Mester Z, Hou X, Zheng C, Yang L (2015) Direct determination of trace antimony in natural waters by photochemical vapor generation ICPMS: method optimization and comparison of quantitation strategies. Anal Chem 87:7996–8004
Meija J, Pagliano E, Mester Z (2014) Coordinate swapping in standard addition graphs for analytical chemistry: a simplified path for uncertainty calculation in linear and nonlinear plots. Anal Chem 86:8563–8567
Meija J, Chartrand MMG (2017) Uncertainty evaluation in normalization of isotope delta measurement results against international referencematerials. Anal Bioanal Chem 413:1061–1069
D’Ulivo L, Yang L, Ding J, Pagliano E, Leek DM, Thibeault M-P, Mester Z (2017) Determination of cyanocobalamin by isotope dilution LC–MS/MS. Anal Chim Acta 990:103–109
Mihai O, Kawamoto MS, LeBlanc KL, Grinberg P, Nogueira ARdA, Mester Z (2019) Determination of chromium picolinate and trace hexavalent chromium in multivitamins and supplements by HPLC-ICP-QQQ-MS. J Food Compos Anal 87:103421. https://doi.org/10.1016/j.jfca.2020.103421
Picoloto RS, Doneda M, Flores ELM, Mesko MF, Flores EMM, Mello PA (2015) Simultaneous determination of bromine and iodine in milk powder for adult and infant nutrition by plasma based techniques after digestion using microwave-induced combustion. Spectrochim Acta Part B 107:86–92
Deveswaran R, Bharath S, Basavaraj B, Abraham I, Furtado S, Madhavan V (2009) Concepts and techniques of pharmaceutical powder mixing process: a current update. Res J Pharm Tech 2(2):245–249
Venables HJ, Wells JI (2010) Powder mixing. Drug Dev Ind Pharm 27(7):599–612
Li J, Wu Y (2014) Lubricants in pharmaceutical solid dosage forms. Lubricants 2:21–43
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188
ISO Guide 35 (2017), Reference materials—guidance for characterization and assessment of homogeneity and stability. ISO Copyright Office, Switzerland
Evaluation of measurement data—Guide to the expression of uncertainty in measurement. JCGM 100:2008
Bureau International des Poids et Mesures (2017). https://kcdb.bipm.org/AppendixC/QM/CA/QM_CA_1.pdf
Sturgeon RE, Methven B, Willie SN, Grinberg P (2014) Assignment of purity to primary metal calibrants using pin-cell VG 9000 glow discharge mass spectrometry: a primary method with direct traceability to the SI international system of units? Metrologia 51:410–422
Grinberg P, D’ulivo L, Nadeau K, Pihillagawa I, Yang L, LeBlanc K, Mihai O, Kawamoto M, Doneda M, Pereira RM, Bizzi CA, Mello PA, Flores EMM, Mesko MF, Leek DM, Thibeault M-P, Meija J, Mester Z (2018) VITA-1: low-level multivitamin certified reference material for minerals and vitamins. National Research Council Canada, Ottawa
Grinberg P, D’ulivo L, Nadeau K, Pihillagawa I, Yang L, LeBlanc K, Mihai O, Kawamoto M, Doneda M, Pereira RM, Bizzi CA, Mello PA, Flores EMM, Mesko MF, Leek DM, Thibeault M-P, Meija J, Mester Z (2018) VITB-1: elevated-level multivitamin certified reference material for minerals and vitamins. National Research Council Canada, Ottawa
Acknowledgements
The contributions of Enea Pagliano and Phuong-Mai Le (NRC), Mayumi Kawamoto (Universidade de São Paulo, Brazil) Morgana Doneda, Rodrigo M. Pereira, Cezar A. Bizzi, Paola A. Mello, Erico M. M. Flores (Universidade Federal de Santa Maria, Brazil), and Marcia F. Mesko (Universidade Federal de Pelotas, Brazil) are acknowledged.
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Grinberg, P., D’Ulivo, L., Nadeau, K. et al. Development of low and elevated level multivitamin and mineral supplement certified reference materials: VITA-1 and VITB-1. Accred Qual Assur 25, 201–220 (2020). https://doi.org/10.1007/s00769-020-01433-9
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DOI: https://doi.org/10.1007/s00769-020-01433-9