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Peritoneal macrophages from adjuvant arthritic rats enhance tumour cell growth in vitro

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Summary

Peritoneal macrophages from rats with adjuvant arthritis enhance the incorporation of3H-thymidine in 2 tumour cell lines in vitro. Maximal enhancement is found during the development of the secondary lesions, and it is suggested that the immunologic commitment of the macrophages could interfere with their regulation of tumour cell proliferation in vivo.

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Authors and Affiliations

  1. Department of Pharmacology, Leo Pharmaceutical Products, DK-2750, Ballerup, Denmark

    L. Binderup, E. Bramm & E. Arrigoni-Martelli

Authors
  1. L. Binderup
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  2. E. Bramm
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  3. E. Arrigoni-Martelli
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Additional information

Acknowledgments. The authors thank Drs P.F. Engel and M.P. Andreasen from the Finsen Institute, Copenhagen, for their gift of tumour cells and Ms E. Greve Petersen, Ms B. Hasselriis and Ms F. Norris for excellent technical assistance.

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Binderup, L., Bramm, E. & Arrigoni-Martelli, E. Peritoneal macrophages from adjuvant arthritic rats enhance tumour cell growth in vitro. Experientia 35, 1230–1232 (1979). https://doi.org/10.1007/BF01963307

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