Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and differentiation along a specific secretory lineage.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Mical modulates Tau toxicity via cysteine oxidation in vivo
Acta Neuropathologica Communications Open Access 04 April 2022
-
Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses
Scientific Reports Open Access 24 November 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Imajo, M. et al. Nat. Cell Biol. 17, 7–19 (2015).
Imajo, M., Ebisuya, M. & Nishida, E. Protoc. Exch. http://dx.doi.org/10.1038/protex.2014.049 (2014).
Kaneda, Y. et al. Mol. Ther. 6, 219–226 (2002).
van de Wetering, M. et al. Cell 111, 241–250 (2002).
Pan, D. Dev. Cell 19, 491–505 (2010).
Barry, E. R. & Camargo, F. D. Curr. Opin. Cell Biol. 25, 247–253 (2013).
Azzolin, L. et al. Cell 158, 157–170 (2014).
Barry, E. R. et al. Nature 493, 106–110 (2013).
Zhou, D. et al. Proc. Natl Acad. Sci. USA 108, E1312–1320 (2011).
Camargo, F. D. et al. Curr. Biol. 17, 2054–2060 (2007).
Katz, J. P. et al. Development 129, 2619–2628 (2002).
Lee, J. H. et al. EMBO J. 27, 1231–1242 (2008).
Beronja, S. et al. Nature 501, 185–190 (2013).
Foreman, P. K. et al. Hum. Gene Ther. 9, 1313–1321 (1998).
Mohr, S. E., Smith, J. A., Shamu, C. E., Neumuller, R. A. & Perrimon, N. Nat. Rev. Mol. Cell Biol. 15, 591–600 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Le Bouteiller, M., Jensen, K. Hippo signalling directs intestinal fate. Nat Cell Biol 17, 5–6 (2015). https://doi.org/10.1038/ncb3086
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3086
This article is cited by
-
Mical modulates Tau toxicity via cysteine oxidation in vivo
Acta Neuropathologica Communications (2022)
-
Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses
Scientific Reports (2016)