Aging, chromatin, and food restriction--connecting the dots

Science. 2000 Sep 22;289(5487):2062-3. doi: 10.1126/science.289.5487.2062.

Abstract

Model organisms such as yeast have proved exceptionally valuable for revealing new information about the molecular pathways involved in the aging of cells. In her Perspective, Campisi comments on new work showing that caloric restriction increases longevity in yeast by activating the SIR2 gene, which alters the compactness of chromatin and thus regulates gene expression (Lin et al.).

Publication types

  • Comment

MeSH terms

  • Aging / physiology*
  • Animals
  • Cell Division
  • Chromatin / physiology*
  • DNA Repair
  • DNA Replication
  • DNA, Circular / metabolism
  • DNA, Fungal / metabolism
  • DNA, Ribosomal / metabolism
  • Energy Intake*
  • Gene Silencing*
  • Glucose / metabolism
  • Histone Deacetylases / genetics
  • Histone Deacetylases / metabolism*
  • Histones / metabolism
  • Longevity
  • Mutation
  • NAD / metabolism
  • Reactive Oxygen Species / metabolism
  • Recombination, Genetic
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae*
  • Sirtuin 2
  • Sirtuins
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*

Substances

  • Chromatin
  • DNA, Circular
  • DNA, Fungal
  • DNA, Ribosomal
  • Histones
  • Reactive Oxygen Species
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • Trans-Activators
  • NAD
  • SIR2 protein, S cerevisiae
  • Sirtuin 2
  • Sirtuins
  • Histone Deacetylases
  • Glucose