The 2023 MDPI Annual Report has
been released!
 
13 pages, 3424 KiB  
Case Report
Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer
by Jamaal C. Jackson, Darren Sanchez, Andrew C. Johns, Matthew T. Campbell, Ahmet M. Aydin, Neriman Gokden, Sanjay Maraboyina, Jason L. Muesse, John F. Ward, Louis L. Pisters, Niki M. Zacharias, Charles C. Guo and Shi-Ming Tu
J. Clin. Med. 2024, 13(12), 3436; https://doi.org/10.3390/jcm13123436 (registering DOI) - 12 Jun 2024
Abstract
Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some [...] Read more.
Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate. Full article
Show Figures

Figure 1

10 pages, 464 KiB  
Article
COVID-19 Infection in Autosomal Dominant Polycystic Kidney Disease and Chronic Kidney Disease Patients: Progression of Kidney Disease
by Silvia Lai, Francesca Tinti, Adolfo Marco Perrotta, Luca Salomone, Rosario Cianci, Paolo Izzo, Sara Izzo, Luciano Izzo, Claudia De Intinis, Chiara Pellicano and Antonietta Gigante
Biomedicines 2024, 12(6), 1301; https://doi.org/10.3390/biomedicines12061301 (registering DOI) - 12 Jun 2024
Abstract
Introduction: the COVID-19 pandemic has brought to light the intricate interplay between viral infections and preexisting health conditions. In the field of kidney diseases, patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Chronic Kidney Disease (CKD) face unique challenges when exposed to [...] Read more.
Introduction: the COVID-19 pandemic has brought to light the intricate interplay between viral infections and preexisting health conditions. In the field of kidney diseases, patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Chronic Kidney Disease (CKD) face unique challenges when exposed to the SARS-CoV-2 virus. This study aims to evaluate whether SARS-CoV-2 virus infection impacts renal function differently in patients suffering from ADPKD and CKD when compared to patients suffering only from CKD. Materials and methods: clinical data from 103 patients were collected and retrospectively analyzed. We compared the renal function of ADPKD and CKD patients at two distinct time points: before COVID-19 infection (T0) and 1 year after the infection (T1). We studied also a subpopulation of 37 patients with an estimated glomerular filtration rate (eGFR) < 60 mL/min and affected by ADPKD and CKD. Results: clinical data were obtained from 59 (57.3%) ADPKD patients and 44 (42.7%) CKD patients. At T1, ADPKD patients had significantly higher serum creatinine levels compared to CKD patients, and a significantly lower eGFR was observed only in ADPKD patients with eGFR < 60 mL/min compared to CKD patients (p < 0.01, p < 0.05; respectively). Following COVID-19 infection, ADPKD–CKD patients exhibited significantly higher variation in both median serum creatinine (p < 0.001) and median eGFR (p < 0.001) compared to CKD patients. Conclusion: the interplay between COVID-19 and kidney disease is complex. In CKD patients, the relationship between COVID-19 and kidney disease progression is more established, while limited studies exist on the specific impact of COVID-19 on ADPKD patients. Current evidence does not suggest that ADPKD patients are at a higher risk of SARS-CoV-2 infection; however, in our study we showed a significant worsening of the renal function among ADPKD patients, particularly those with an eGFR < 60 mL/min, in comparison to patients with only CKD after a one-year follow-up from COVID-19 infection. Full article
Show Figures

Figure 1

10 pages, 751 KiB  
Article
Efficiency of Orthopaedic Audits in a Level-1 Trauma Centre Using a Modified Clavien–Dindo Complications Classification
by Adrian J. Talia, Nicholas Furness and Susan M. Liew
Complications 2024, 1(1), 14-23; https://doi.org/10.3390/complications1010004 (registering DOI) - 12 Jun 2024
Abstract
Background: Complications are an inevitable part of orthopaedic surgery, and how one defines complications can have an impact on the ability to learn from them. There have been issues with a commonly used classification system first outlined by Clavien and Dindo. Our aim [...] Read more.
Background: Complications are an inevitable part of orthopaedic surgery, and how one defines complications can have an impact on the ability to learn from them. There have been issues with a commonly used classification system first outlined by Clavien and Dindo. Our aim was to evaluate a modification of this classification system developed for use in our department, with our hypothesis being that this could make our audit presentations more efficient. Methods: A modified Clavien–Dindo Classification was prospectively applied to all complications recorded in the orthopaedic departmental audits at our institution for a 12-month period. The audit discussion was recorded and analysed and compared with the complication audits for the preceding 12-month period. Results: We analysed eight audit presentations before and eight audit presentations after the introduction of a modified Clavien–Dindo classification to our orthopaedic complications over a 2-year period. The number of PowerPoint™ slides (103 vs. 84, p = 0.03) and the time spent on each presentation (88 vs. 71 min, p = 0.02) decreased significantly with the introduction of the modified classification. The novel system was found to have high inter-observer reliability. Conclusions: The modified Clavien–Dindo classification system is a reproducible classification system for orthopaedic complications. It made our audit presentations more efficient. Full article
Show Figures

Figure 1

13 pages, 693 KiB  
Article
Neosporosis in Naturally Infected Sheep Herds, a Prospective Cohort Study over Three Years
by Sharon Tirosh-Levy, Omri Asher, Michal Peri Markovich, Daniel Yasur Landau, Elena Blinder and Monica L. Mazuz
Parasitologia 2024, 4(2), 209-221; https://doi.org/10.3390/parasitologia4020018 (registering DOI) - 12 Jun 2024
Abstract
Background: Neospora caninum is a protozoan parasite and a main cause of abortions in cattle worldwide. However, its role in abortions and decreased fertility in sheep is not completely understood, especially due to the complex, multifactorial etiology of abortions. This study aimed to [...] Read more.
Background: Neospora caninum is a protozoan parasite and a main cause of abortions in cattle worldwide. However, its role in abortions and decreased fertility in sheep is not completely understood, especially due to the complex, multifactorial etiology of abortions. This study aimed to perform a longitudinal field study to investigate the epidemiology of neosporosis and its effect on fertility in endemic sheep herds. Methods: Serological (IFAT) and clinical (outcome of pregnancy) data from 153 ewe-lambs was collected in four intensive management farms in Israel during three consecutive pregnancies. Results: The seroprevalence in ewe-lambs at different farms varied between 24% and 93%. The overall seroprevalence increased from 50% in ewe-lambs to 96.6% at the end of the third pregnancy. Horizontal infection was observed in all farms, with seroconversion in 59% of seronegative sheep. Abortion rates were lower (p = 0.004) in seropositive ewes in the first pregnancy and not significantly higher in seropositive sheep in consecutive pregnancies. Seropositivity or seroconversion were not associated with abortions or repeated abortions; however, many aborting ewes were removed from the flock. Conclusions: No direct short- or long-term association was found between Neopsora infection and abortions. The variations between flocks and pregnancies suggest a more complex etiology. Full article
Show Figures

Figure 1

14 pages, 247 KiB  
Article
Climate and Climatic Variations’ Impact on Lymphoedema: Patient Perspective
by Susan Witt, Thomas Dieterle, Susan Gordon, Narelle Campbell and Neil Piller
Lymphatics 2024, 2(2), 119-132; https://doi.org/10.3390/lymphatics2020010 (registering DOI) - 12 Jun 2024
Abstract
Lymphoedema is a chronic and dynamic condition that requires the investment of time and resources to appropriately manage. It fluctuates in response to illness, activity, and age, as well as in response to environmental conditions. This qualitative study explored the impact of the [...] Read more.
Lymphoedema is a chronic and dynamic condition that requires the investment of time and resources to appropriately manage. It fluctuates in response to illness, activity, and age, as well as in response to environmental conditions. This qualitative study explored the impact of the climate and climatic variations on lymphoedema. Focus groups were completed with patients (n = 12) and therapists (n = 7) to explore, in depth, their experiences of managing lymphoedema throughout the year. The results suggested that heat and humidity definitely alter the severity of lymphoedema, and a range of individual strategies are required in order to control symptoms. Central to effectively managing lymphoedema is the notion that every body is different and every lymphoedema is different, and therefore understanding one’s own body, what it needs, and what resources are available is essential in maintaining lymphoedema in the face of climate change. Full article
10 pages, 443 KiB  
Article
Linguistic Validation and Reliability of the Croatian Version of the TOPICOP Questionnaire
by Adela Markota Čagalj, Josko Markic, Dubravka Vuković, Zdenka Šitum Čeprnja, Tina Gogić Salapić, Ivan Buljan and Shelly Melissa Pranić
Medicina 2024, 60(6), 968; https://doi.org/10.3390/medicina60060968 (registering DOI) - 12 Jun 2024
Abstract
Background and Objectives: This study demonstrates the factor structure and reliability of the Croatian version of the TOPICOP (Topical Corticosteroid Phobia) questionnaire, thereby contributing to further validation and standardization of the measurement of topical corticophobia with dermatological patients or their parents, which [...] Read more.
Background and Objectives: This study demonstrates the factor structure and reliability of the Croatian version of the TOPICOP (Topical Corticosteroid Phobia) questionnaire, thereby contributing to further validation and standardization of the measurement of topical corticophobia with dermatological patients or their parents, which directly affects patient or parent compliance, as well as the final therapeutic effect. Materials and Methods: The cross-sectional, observational study was conducted at the University Hospital Centre Split, Department of Dermatovenerology. The research involved inviting 120 participants (age 12–68) who attended the University Hospital Centre Split’s Atopy School, patients examined in the Dermatology Outpatient Clinic of the University Hospital Centre Split and diagnosed with atopic dermatitis (AD) or allergic contact dermatitis (ACD), and parents or legal representatives of patients younger than 12 years old. The TOPICOP questionnaire consists of 12 items assessing the three different components of topical corticophobia (worries, beliefs, and behaviour). Respondents evaluated their perception of the correctness of each statement within 10 min of filling out the questionnaire on a four-point Likert scale. Results: The response rate was 94%, resulting in a sample of 113 respondents (109 adults and 4 children). Factor analysis yielded one common factor of relatively high reliability (Cronbach α = 0.85, 95% CI 0.81 to 0.89). No differences were found in questionnaire scores between male and female participants, nor between the parents/legal representatives of dermatological patients and other patients. Conclusions: This research contributes to further development of the appropriate measuring instrument, its practical application, and thus, the better recognition, resolution, and prevention of topical corticophobia as part of the better overall healthcare and treatment of chronic dermatological patients. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Atopic Dermatitis in Adults and Children)
Show Figures

Figure 1

10 pages, 1402 KiB  
Systematic Review
Remimazolam-Induced Anaphylaxis and Cardiovascular Collapse: A Narrative Systematic Review of Eleven Cases
by Jaemoon Lee and Seong-Hyop Kim
Medicina 2024, 60(6), 971; https://doi.org/10.3390/medicina60060971 (registering DOI) - 12 Jun 2024
Abstract
Background and Objectives: Remimazolam, a novel benzodiazepine, is used for procedural sedation and general anesthesia due to its rapid onset and short duration of action. However, remimazolam-induced anaphylaxis (RIA) is a rare but severe complication. This study aimed to analyze RIA characteristics, [...] Read more.
Background and Objectives: Remimazolam, a novel benzodiazepine, is used for procedural sedation and general anesthesia due to its rapid onset and short duration of action. However, remimazolam-induced anaphylaxis (RIA) is a rare but severe complication. This study aimed to analyze RIA characteristics, focusing on cardiovascular collapse, and provide guidelines for safe remimazolam use. Methods: This study conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Research articles retrieved from PubMed on 26 May 2023, using the keywords ‘remimazolam AND anaphylaxis’ were evaluated based on the inclusion criteria of being written in English and aligning with the World Allergy Organization criteria for anaphylaxis, while studies not meeting these criteria were excluded. All published articles up to the search date were included without any date restrictions. The review analyzed factors such as age, sex, type of anesthesia, remimazolam dose (bolus/continuous), allergic symptoms and sign, epinephrine use, serum tryptase levels, and skin prick tests. Results: Among eleven cases, the mean age was 55.6 ± 19.6 years, with 81.8% male. Hypotension (81.8%) was the most common symptom, followed by bradycardia (54.5%) and desaturation (36.4%). Two patients experienced cardiac arrest. Serum tryptase levels confirmed anaphylaxis in ten cases. Epinephrine was the primary treatment, with intravenous doses ranging from 0.1 mg to 0.3 mg. Conclusions: Vigilance is crucial when administering remimazolam, adhering to recommended dosages, and promptly treating RIA with epinephrine. Further research is needed to understand the risk factors and refine the management strategies. Guidelines for safe remimazolam use are proposed. Full article
(This article belongs to the Section Intensive Care/ Anesthesiology)
Show Figures

Figure 1

8 pages, 1773 KiB  
Case Report
Critical Hemorrhage Caused by a Size-Mismatched Extracorporeal Membrane Oxygenation Cannula in a Patient with Myotonic Dystrophy Type 1: A Case Report and Literature Review
by Changsik Shin, Kwon Cheol Yoo and Dae Hoon Kim
Medicina 2024, 60(6), 969; https://doi.org/10.3390/medicina60060969 (registering DOI) - 12 Jun 2024
Abstract
Background and Objective: Although extracorporeal membrane oxygenation (ECMO) is an essential life-saving technique for patients with refractory cardiopulmonary shock, it can be fatal in certain cases. Case Presentation: A 19-year-old girl treated with ECMO presented with acute limb ischemia 2 days [...] Read more.
Background and Objective: Although extracorporeal membrane oxygenation (ECMO) is an essential life-saving technique for patients with refractory cardiopulmonary shock, it can be fatal in certain cases. Case Presentation: A 19-year-old girl treated with ECMO presented with acute limb ischemia 2 days after cannula removal. The decannulation was performed percutaneously by an interventional cardiologist, and the vascular surgery department was consulted after the patient developed symptoms. The first suspected diagnosis was thrombosis due to incorrect use of the closure device. However, the artery had ruptured due to the insertion of a catheter with a cannula that was larger than the patient’s artery. Management and Outcome: Fortunately, excessive bleeding due to the size-mismatched cannula was prevented by an unintentional complication of the closing device, which saved the patient’s life. She underwent a right common femoral artery thrombectomy and patch angioplasty. Hospital guidelines have changed regarding the surgical removal of ECMO cannulas. Discussion: This report aims to highlight the importance of two aspects that are critical to a successful outcome: individualized cannula selection followed by precise insertion and removal and postoperative evaluation of a patient’s final status. Full article
(This article belongs to the Section Surgery)
Show Figures

Figure 1

11 pages, 1050 KiB  
Article
Depression in the Perinatal Period: Course and Outcome of Depression in the Period from the Last Trimester of Pregnancy to One Year after Delivery in Primiparous Mothers
by Olivera Zikic, Jelena Stojanov, Jelena Kostic, Gordana Nikolic, Suzana Tosic Golubovic, Maja Simonovic, Vladimir Djordjevic and Iva Binic
Medicina 2024, 60(6), 970; https://doi.org/10.3390/medicina60060970 (registering DOI) - 12 Jun 2024
Abstract
Background and Objectives: One of the most significant psychiatric problems in women is depression related to the perinatal period. Our study aims to determine the frequency and course of depressive symptomatology in the perinatal period with particular reference to objective rate and [...] Read more.
Background and Objectives: One of the most significant psychiatric problems in women is depression related to the perinatal period. Our study aims to determine the frequency and course of depressive symptomatology in the perinatal period with particular reference to objective rate and outcome of postpartum depression. Materials and Methods: One hundred and eighty-eight pregnant/postnatal women were included in a prospective, longitudinal, observational study during which the depressive symptomatology was estimated at the third trimester of pregnancy, and the first, sixth, and twelfth month‚ postpartum. All participants completed a semi-structured sociodemographic questionnaire constructed for research purposes, the Edinburgh Postnatal Depression Scale, Toronto Alexithymia Scale, Beck Anxiety Inventory, and The Mood Disorder Questionnaire at each time point. Postpartum depression diagnosis was confirmed by a trained and certified psychiatrist with long-standing experience. For a better understanding of the trajectory of depressive symptomatology and genuine postpartum depression, we classified depression into those with new-onset and those left over from the previous observation period. Results: In general, 48.9% of participants in the study were depressed at some point during the investigation. A total of 10.6% of women were depressed in the third trimester. The highest percentage of new-onset depression (25%) was in the first month after giving birth and was maintained for up to six months, after which the appearance was sporadic. Most of the postpartum depression resolved in the period from the first month to the sixth month after childbirth (20.7%). The episodes mainly had characteristics of unipolar depression. Conclusions: Our results imply that a new onset of depression is most intensive during the first six months, and after that, it is sporadic. Further studies are needed to explore whether all depressive symptomatology in the postnatal period is the same, or perhaps postpartum depression, classified in this way, has specific characteristics, etiology, and consequently different treatment and preventive options. Full article
(This article belongs to the Section Psychiatry)
Show Figures

Figure 1

20 pages, 4293 KiB  
Article
Fast High-Resolution pKa Spectrotitrimetry for Quantification of Surface Functional Groups of Retisols
by Natal’ya V. Matveeva, Andrei V. Garmash, Mikhail A. Shishkin, Alexey A. Dymov, Olga B. Rogova, Dmitry S. Volkov and Mikhail A. Proskurnin
Soil Syst. 2024, 8(2), 63; https://doi.org/10.3390/soilsystems8020063 (registering DOI) - 12 Jun 2024
Abstract
Potentiometric titration in a fast and simultaneously high-resolution modality was proposed for the identification and quantification of protolytic groups of variable strength at the surface of primary soil particles. The method is implemented by titrimetric data processing as multicomponent spectra (pKa [...] Read more.
Potentiometric titration in a fast and simultaneously high-resolution modality was proposed for the identification and quantification of protolytic groups of variable strength at the surface of primary soil particles. The method is implemented by titrimetric data processing as multicomponent spectra (pKa spectrotitrimetry). Due to the high resolution, the error of acidity-constant assessment (3–5%) is lower, compared to existing approaches; due to the fast titration, the effect of soil hydrolysis is minimized. The soil profiles for acidic Retisols (podzolic soils)—under a spruce crown and in the intercrown space—were studied. These soils, which have similar bulk properties and genesis but developed under different plant covers, were distinguished by pKa spectral features at 4–5; 5.5–6.5; 6.5–8.5; 7.5–8.5; and 9–10, as well as total group concentrations. Differences in acidic and basic-group distribution (carboxyl groups, amorphous aluminosilicates, carbonate species, amino groups, soluble (poly)phenolic compounds, phospholipids) and Al and Fe complex compounds within the same soil profiles and between two Retisols were found and quantified. The acidity constants and group concentrations found by pKa spectrotitrimetry were compared with conventional soil-composition indicators (total organic carbon, oxalate-soluble Fe and Al, and phosphorus), using principal component analysis. The main correlations are between the concentrations of oxalate-soluble Al and groups with pKa values of 5.0–6.5 and 8.5; oxalate-soluble Fe and pKa values of 9.0–10.0; and P2O5 and pKa values of 4.0–6.0 and 6.5–8.5. The method provides a set of major acidity values without a priori information on a soil sample and can be used for screening and identifying similar soils. Full article
Show Figures

Figure 1

14 pages, 2442 KiB  
Article
Research on Filtering Algorithm of Vehicle Dynamic Weighing Signal
by Lingcong Xiong, Tieyi Zhang, Anlu Yuan and Zhipeng Zhang
World Electr. Veh. J. 2024, 15(6), 254; https://doi.org/10.3390/wevj15060254 (registering DOI) - 12 Jun 2024
Abstract
This study analyzes the advantages and disadvantages of filtering algorithms for dynamic weighing signals. Highway road surface has road surface unevenness and other influencing factors. The body vibration of the vehicle driving process produces a certain amount of interference signals collected by the [...] Read more.
This study analyzes the advantages and disadvantages of filtering algorithms for dynamic weighing signals. Highway road surface has road surface unevenness and other influencing factors. The body vibration of the vehicle driving process produces a certain amount of interference signals collected by the load cell to form noise signals. In addition, piezoelectric sensors and amplification circuits introduce a large amount of electrical noise. These noise signals are non-smooth, nonlinear, and have other characteristics. We study the filtering effects of moving average (MA), wavelet transform (WT), and variational mode decomposition (VMD) filtering algorithms on axle weight signals and evaluate the performance of the filtering algorithms through the Root Mean Square Error (RMSE), signal-to-noise ratio (SNR), and Normalized Correlation Coefficient (NCC). The comprehensive analysis shows that the variational modal decomposition filtering algorithm is more advantageous for axial weight signal processing. The design of the axle weight signal noise filtering algorithm is of great significance for improving the accuracy of the overall dynamic weighing system of the vehicle. Full article
Show Figures

Figure 1

22 pages, 13426 KiB  
Article
Efficient Motion Primitives-Based Trajectory Planning for UAVs in the Presence of Obstacles
by Marta Manzoni, Roberto Rubinacci and Davide Invernizzi
Drones 2024, 8(6), 256; https://doi.org/10.3390/drones8060256 (registering DOI) - 12 Jun 2024
Abstract
The achievement of full autonomy in Unmanned Aerial Vehicles (UAVs) is significantly dependent on effective motion planning. Specifically, it is crucial to plan collision-free trajectories for smooth transitions from initial to final configurations. However, finding a solution executable by the actual system adds [...] Read more.
The achievement of full autonomy in Unmanned Aerial Vehicles (UAVs) is significantly dependent on effective motion planning. Specifically, it is crucial to plan collision-free trajectories for smooth transitions from initial to final configurations. However, finding a solution executable by the actual system adds complexity: the planned motion must be dynamically feasible. This involves meeting rigorous criteria, including vehicle dynamics, input constraints, and state constraints. This work addresses optimal kinodynamic motion planning for UAVs in the presence of obstacles by employing a hybrid technique instead of conventional search-based or direct trajectory optimization approaches. This technique involves precomputing a library of motion primitives by solving several Two-Point-Boundary-Value Problems (TPBVP) offline. This library is then repeatedly used online within a graph-search framework. Moreover, to make the method computationally tractable, continuity between consecutive motion primitives is enforced only on a subset of the state variables. This approach is compared with a state-of-the-art quadrotor-tailored search-based approach, which generates motion primitives online through control input discretization and forward propagation of the dynamic equations of a simplified model. The effectiveness of both methods is assessed through simulations and real-world experiments, demonstrating their ability to generate resolution-complete, resolution-optimal, collision-free, and dynamically feasible trajectories. Finally, a comparative analysis highlights the advantages, disadvantages, and optimal usage scenarios for each approach. Full article
Show Figures

Figure 1

5 pages, 1258 KiB  
Technical Note
Orthopedic Surgery Position Enhances Safety in Adults with Cervical Rigidity during Cochlear Implantation
by Chiara Lazzarin and Antonio Frisina
J. Otorhinolaryngol. Hear. Balance Med. 2024, 5(1), 8; https://doi.org/10.3390/ohbm5010008 (registering DOI) - 12 Jun 2024
Abstract
Cochlear implantation is the therapy used for patients with severe to profound sensorineural hearing loss. For the success of the surgery, it is important that each surgical step is performed with meticulous precision, starting from the correct patient position on the operating table. [...] Read more.
Cochlear implantation is the therapy used for patients with severe to profound sensorineural hearing loss. For the success of the surgery, it is important that each surgical step is performed with meticulous precision, starting from the correct patient position on the operating table. In elderly or obese patients, this can be difficult to achieve due to cervical rigidity. With this technical note, we want to describe a new position from orthopedic surgery to perform a posterior tympanotomy accurately, ensuring a safe procedure and avoiding unpleasant complications. Full article
Show Figures

Figure 1

25 pages, 8137 KiB  
Article
Research on Unmanned Aerial Vehicle (UAV) Visual Landing Guidance and Positioning Algorithms
by Xiaoxiong Liu, Wanhan Xue, Xinlong Xu, Minkun Zhao and Bin Qin
Drones 2024, 8(6), 257; https://doi.org/10.3390/drones8060257 (registering DOI) - 12 Jun 2024
Abstract
Considering the weak resistance to interference and generalization ability of traditional UAV visual landing navigation algorithms, this paper proposes a deep-learning-based approach for airport runway line detection and fusion of visual information with IMU for localization. Firstly, a coarse positioning algorithm based on [...] Read more.
Considering the weak resistance to interference and generalization ability of traditional UAV visual landing navigation algorithms, this paper proposes a deep-learning-based approach for airport runway line detection and fusion of visual information with IMU for localization. Firstly, a coarse positioning algorithm based on YOLOX is designed for airport runway localization. To meet the requirements of model accuracy and inference speed for the landing guidance system, regression loss functions, probability prediction loss functions, activation functions, and feature extraction networks are designed. Secondly, a deep-learning-based runway line detection algorithm including feature extraction, classification prediction and segmentation networks is designed. To create an effective detection network, we propose efficient loss function and network evaluation methods Finally, a visual/inertial navigation system is established based on constant deformation for visual localization. The relative positioning results are fused and optimized with Kalman filter algorithms. Simulation and flight experiments demonstrate that the proposed algorithm exhibits significant advantages in terms of localization accuracy, real-time performance, and generalization ability, and can provide accurate positioning information during UAV landing processes. Full article
(This article belongs to the Special Issue Path Planning, Trajectory Tracking and Guidance for UAVs)
Show Figures

Figure 1

22 pages, 1814 KiB  
Article
A Novel Stochastic Model for Human Norovirus Dynamics: Vaccination Impact with Lévy Noise
by Yuqin Song, Peijiang Liu and Anwarud Din
Fractal Fract. 2024, 8(6), 349; https://doi.org/10.3390/fractalfract8060349 (registering DOI) - 12 Jun 2024
Abstract
The epidemic norovirus causes vomiting and diarrhea and is a highly contagious infection. The disease is affecting human lives in terms of deaths and medical expenses. This study examines the governing dynamics of norovirus by incorporating Lévy noise into a stochastic [...] Read more.
The epidemic norovirus causes vomiting and diarrhea and is a highly contagious infection. The disease is affecting human lives in terms of deaths and medical expenses. This study examines the governing dynamics of norovirus by incorporating Lévy noise into a stochastic SIRWF (susceptible, infected, recovered, water contamination, and food contamination) model. The existence of a non-negative solution and its uniqueness are proved after model formulation. Subsequently, the threshold parameter is calculated, and this number is used to explore the conditions under which disease tends to exist in the population. Likewise, additional conditions are derived that ensure the elimination of the disease from the community. It is proved that the norovirus is extinct whenever the threshold parameter is less than one and it persists for Rs>1. The work assumes two working examples to numerically explain the theoretical findings. Simulations of the study are visually presented, and comparisons are made. The results of this study suggest a robust approach for handling complex biological and epidemic phenomena. Full article
Show Figures

Figure 1

16 pages, 659 KiB  
Article
Relationship between Decision-Making Styles and Leadership Styles of Portuguese Fire Officers
by Carlos Rouco, Pedro Marques-Quinteiro, Vítor Reis and Isabel Duarte
Fire 2024, 7(6), 196; https://doi.org/10.3390/fire7060196 (registering DOI) - 12 Jun 2024
Abstract
Numerous studies in management and leadership indicate that one’s decision-making style is reflective of one’s leadership style. In the context of civil protection and the fire service, the ability of the fire officers to adopt the best style of decision-making and leadership in [...] Read more.
Numerous studies in management and leadership indicate that one’s decision-making style is reflective of one’s leadership style. In the context of civil protection and the fire service, the ability of the fire officers to adopt the best style of decision-making and leadership in each situation represents a critical factor of success. Therefore, the present study was designed to examine the relationship between decision-making and the leadership style of fire officers. For this study, a quantitative method was used, with the application of questionnaires with closed questions. A sample of 346 officers of Portuguese fire stations answered the questionnaire. Correlations between styles are consistent with findings from other studies. Decision-making styles directly influence the leadership styles adopted. Fire officers prioritize people and social concerns, involving teams in decision-making. Research shows positive correlations between participants’ roles, conceptual decision-making, and relation-focused leadership. Higher academic degrees are associated with relationship-focused leadership. Behavioral decision-making mediates the impact of education on leadership styles. Full article
(This article belongs to the Section Fire Social Science)
Show Figures

Figure 1

17 pages, 9433 KiB  
Article
Cloning, Expression, Enzymatic Characterization and Mechanistic Studies of M13 Mutant Acetohydroxyacid Synthase That Rescues Valine Feedback Inhibition
by Yaqing Tan, Xingxing Gao, Zhiqiang An, Nan Wang, Yaqian Ma and Hailing Zhang
Fermentation 2024, 10(6), 311; https://doi.org/10.3390/fermentation10060311 (registering DOI) - 12 Jun 2024
Abstract
Acetohydroxyacid synthase (AHAS) is a key enzyme in the first step of the branched-chain amino acid synthesis pathway, and the production of acetohydroxybutyrate from one molecule of 2-ketobutyric acid and one molecule of pyruvate. AHAS is inhibited by feedback from L-valine, L- [...] Read more.
Acetohydroxyacid synthase (AHAS) is a key enzyme in the first step of the branched-chain amino acid synthesis pathway, and the production of acetohydroxybutyrate from one molecule of 2-ketobutyric acid and one molecule of pyruvate. AHAS is inhibited by feedback from L-valine, L-leucine, and L-isoleucine, and the expression of ilvBN, the gene encoding AHAS, is regulated by all three branched-chain amino acids. A change in amino acids 20–22 on the regulatory subunit (M13 mutation) removes the feedback inhibition by valine. We cloned the gene encoding AHAS (ilvBN) into a vector and then transfected it into Escherichia coli BL21 for expression with targeted changes in amino acids 20–22 on the regulatory subunit, and then determined the activity of the mutated AHAS and its inhibitory effects on valine, isoleucine, and leucine. The enzyme containing the M13 mutation was feedback resistant to all three amino acids. Previous studies have suggested that the binding sites for the three branched-chain amino acids may be at the same variable center. We investigated the enzymatic properties of wild-type and mutant AHAS, modeled their crystal structures, and resolved the mechanism of feedback inhibition induced by mutant M13, which will be useful for continuing the modification of AHAS and the design of broad-spectrum herbicides. Full article
(This article belongs to the Section Microbial Metabolism, Physiology & Genetics)
Show Figures

Figure 1

16 pages, 1183 KiB  
Article
Simultaneous Determination of Multi-Class Mushroom Toxins in Mushroom and Biological Liquid Samples Using LC-MS/MS
by Junjia Lu, Jing Zhang, Haijiao Li and Chengye Sun
Separations 2024, 11(6), 183; https://doi.org/10.3390/separations11060183 (registering DOI) - 12 Jun 2024
Abstract
A comprehensive analytical method based on liquid chromatography–tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous detection of 12 mushroom toxins (ibotenic acid, muscimol, muscarine, β-amanitin, α-amanitin, desoxoviroidin, γ-amanitin, phallisacin, illudin S, phallacidin, phalloidin and illudin M) in mushrooms, serum, urine and simulated [...] Read more.
A comprehensive analytical method based on liquid chromatography–tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous detection of 12 mushroom toxins (ibotenic acid, muscimol, muscarine, β-amanitin, α-amanitin, desoxoviroidin, γ-amanitin, phallisacin, illudin S, phallacidin, phalloidin and illudin M) in mushrooms, serum, urine and simulated gastric fluid. The samples were extracted with water or acetonitrile solution, and the serum sample was further purified with PSA sorbent. Chromatographic separation was performed on an ACQUITY UPLC HSS T3 column with gradient elution using methanol and water containing 1 mM ammonia fluoride as a mobile phase. Mass spectrometric acquisition was performed in electrospray positive ionization mode. Good linearities (R2 > 0.994) were obtained for 12 toxins over the range of 0.05~200 µg/L. Matrix-matched calibration curves were used for quantification. The method limits of quantification were 0.01~0.2 mg/kg for mushrooms and 0.15~2.0 µg/L for three biological liquid samples. The mean recoveries of 12 target toxins (spiked at three concentration levels) ranged from 73.0% to 110.3%, with relative standard deviations not exceeding 19.4%, which meets the requirements for the determination of trace compounds in a biological matrix. This method was applied to the analysis of mushroom samples from Yunnan Province. As a result, 11 toxins, not including illudin M, were detected with a concentration range of 0.61~2143 mg/kg. Full article
Show Figures

Figure 1

15 pages, 4310 KiB  
Article
Genome-Wide Identification, Characterization, and Expression of the HAK/KUP/KT Potassium Transporter Gene Family in Poncirus trifoliata and Functional Analysis of PtKUP10 under Salt Stress
by Longfei Jin, Xinxing Yin, Mingxia Wen, Bei Huang, Feng Liu, Xinguo Li and Peng Wang
Horticulturae 2024, 10(6), 628; https://doi.org/10.3390/horticulturae10060628 (registering DOI) - 12 Jun 2024
Abstract
Potassium is an essential mineral nutrient for citrus growth and stress response. In this study, the HAK/KUP/KT gene family was identified from the genome of trifoliate orange (Poncirus trifoliata). The physical and chemical properties, chromosomal location, gene structure, evolutionary relationship, conserved [...] Read more.
Potassium is an essential mineral nutrient for citrus growth and stress response. In this study, the HAK/KUP/KT gene family was identified from the genome of trifoliate orange (Poncirus trifoliata). The physical and chemical properties, chromosomal location, gene structure, evolutionary relationship, conserved motifs, and tissue expression characteristics were analyzed. The expression characteristics under low potassium and salt stress were analyzed by fluorescence quantitative PCR. The function of PtKUP10 was investigated by heterologous expression in Arabidopsis thaliana. The results showed that at least 18 PtKUPs were distributed in seven chromosomes. Phylogenetic analysis showed that four PtKUPs clustered in clade I, which mediated the high-affinity potassium absorption. Gene expression analysis showed that four PtKUPs were highly expressed in root, seven PtKUPs were up-regulated by low potassium stress, and nine PtKUPs were up-regulated by salt stress. The cis-acting elements on the promoter of PtKUPs were predominantly involved in stress and hormone responses. Overexpression of PtKUP10 in Arabidopsis thaliana could enhance salt tolerance by accumulating more potassium in the shoot and reducing sodium content in the shoots and roots. These results indicated that PtKUPs play important roles in potassium absorption and salt stress response, and PtKUP10 might enhance salt tolerance by maintaining potassium and sodium homeostasis. Full article
Show Figures

Figure 1

15 pages, 3239 KiB  
Article
Different Oligosaccharides Induce Coordination and Promotion of Root Growth and Leaf Senescence during Strawberry and Cucumber Growth
by Yanan Xu, Yan Han, Wei Han, Yigang Yang, Makoto Saito, Guohua Lv, Jiqing Song and Wenbo Bai
Horticulturae 2024, 10(6), 627; https://doi.org/10.3390/horticulturae10060627 (registering DOI) - 12 Jun 2024
Abstract
Oligosaccharides, as a wide type of polysaccharide, have a broad antimicrobial spectrum and promote development as plant growth stimulants. To investigate the regulation effects of different oligosaccharides on the dynamic changes of chlorophyll content, leaf fluorescence, root activity and morphology, and chloroplast ultrastructure, [...] Read more.
Oligosaccharides, as a wide type of polysaccharide, have a broad antimicrobial spectrum and promote development as plant growth stimulants. To investigate the regulation effects of different oligosaccharides on the dynamic changes of chlorophyll content, leaf fluorescence, root activity and morphology, and chloroplast ultrastructure, as well as the yields and yield components of strawberry and cucumber, typical greenhouse experiments were conducted over two years (2021–2022). The experimental plants were foliar sprayed with tap water (CK), chitosan oligosaccharide (CSOS), and mixed oligosaccharides (MixOS) five times before flowering. The conventional management (CM) was conducted as a conventional control. The findings of the present study suggest that the application of MixOS has the greatest regulation effects on delayed leaf senescence, well-developed roots, and higher fruit productions of strawberry and cucumber. Exogenous MixOS resulted in significant increases in SPAD values, maximum photochemical efficiency (Fv/Fm), and photochemical quenching coefficiency (qP); they were increased by 1.94–28.96%, 5.41–33.89%, and 9.93–62.07%, compared to the CSOS, CM, and CK treatments, respectively. The orderly and steady structure of thylakoids in the chloroplast, and the randomly distributed starch grains, could be clearly observed in the MixOS treatment, while the non-photochemical quenching (NPQ) was correspondingly reduced by 19.04–45.92%. Meanwhile, the remarkable promotion of root activity and root surface morphology indicators (i.e., root length, surface area, average diameter, and volume) could be observed when exposed to the MixOS treatments, and the total yields of strawberry and cucumber were all increased by 12.40–25.57%. These findings suggest that the mixed oligosaccharides mainly promote the coordinated growth of root and shoot, which leads to the improved yields of strawberry and cucumber. Full article
(This article belongs to the Section Fruit Production Systems)
Show Figures

Figure 1

12 pages, 229 KiB  
Article
DNA Testing and Identities in Family History Research
by Emma L. Shaw, Debra J. Donnelly, Gideon Boadu, Rachel Burke and Robert J. Parkes
Genealogy 2024, 8(2), 75; https://doi.org/10.3390/genealogy8020075 (registering DOI) - 12 Jun 2024
Abstract
In the preceding decades, rapid technological advancements and increasing democratisation of historical records have been coupled with scientific data from DNA testing, which has revolutionised the family history industry. Going beyond the traditional archives and databases, DNA profiles present nuanced confirmations, puzzles, and [...] Read more.
In the preceding decades, rapid technological advancements and increasing democratisation of historical records have been coupled with scientific data from DNA testing, which has revolutionised the family history industry. Going beyond the traditional archives and databases, DNA profiles present nuanced confirmations, puzzles, and contradictions generated through this biological lens. Family history researchers seek iterative engagements with their familial pasts and, in the process, amplify their contemporary identities. This specialised group of historians illuminates their families’ travels through the broader historical landscape, constructing micro-narratives using a broad range of investigative modalities. This article reports on the findings of a large international study (n = 1016) that investigated family history researchers’ motivations for undertaking DNA testing, their experiences, and its impact on their perceptions of individual, national, and global identities using Berzonsky’s socio-cultural model of identity construction (2003, 2011) as an analytic frame. Using a survey methodology, it was concluded that DNA testing can expand and disrupt long-held notions of identity and has the power to shift perceptions and understandings of the self while simultaneously providing a new era of opportunity to reconceptualise national and international affiliations. It suggests further investigative avenues to assess the potential of DNA testing, which may promote social cohesion, inclusiveness, and global citizenship. Full article
27 pages, 992 KiB  
Article
Natural Disasters and Human Development in Asia–Pacific: The Role of External Debt
by Markus Brueckner, Sudyumna Dahal and Haiyan Lin
J. Risk Financial Manag. 2024, 17(6), 246; https://doi.org/10.3390/jrfm17060246 (registering DOI) - 12 Jun 2024
Abstract
The average country in Asia–Pacific experiences more natural disasters than average countries of other developing regions. This paper presents stylized facts on natural disasters, human development, and external debt in Asia–Pacific. The paper also contains estimates of the effects that natural disasters have [...] Read more.
The average country in Asia–Pacific experiences more natural disasters than average countries of other developing regions. This paper presents stylized facts on natural disasters, human development, and external debt in Asia–Pacific. The paper also contains estimates of the effects that natural disasters have on human development. Controlling for country- and time-fixed effects, the dynamic panel model estimates show that external debt has a mitigating effect on the adverse impacts that natural disasters have on human development; in countries with low external debt-to-GDP ratios, natural disasters significantly decrease the human development index, but not so in countries with high external debt-to-GDP ratios. External debt (i.e., borrowing from abroad) is a financial contract for obtaining resources from abroad (i.e., imports of goods and services). When a country experiencing a natural disaster borrows from abroad to increase imports of goods and services, the population suffers less when a natural disaster strikes. Natural disasters destroy goods and capital (e.g., food, machinery, buildings, and roads) in the countries in which they occur. If imports of goods and services do not increase, then the population has less goods and services to consume following a natural disaster. By increasing imports, which are mirrored on the financial side by an increase in external debt, the population of a country that was struck by a natural disaster can experience consumption smoothing. As the incidence of natural disasters increases globally, a policy recommendation for disaster-prone countries, supported by the empirical results of this paper, is the need for deeper and innovative mechanisms of access to international financing, including reforms in both domestic and international financial systems. The paper’s most significant contribution is the unique lens through which it analyzes the often-studied subject of natural disasters. Rather than looking at disasters as merely adverse events and debt as an unwelcome obligation in isolation, it connects the two and uncovers the paradoxically positive and beneficial role a healthy level of external debt can play in mitigating the adverse effects of these disasters. It provides a fresh perspective, a shift in thinking that may immensely benefit external debt and disaster management policies. Full article
Show Figures

Figure 1

10 pages, 2387 KiB  
Article
Monte Carlo Simulation of Quantum-Cutting Nanocrystals as the Luminophore in Luminescent Solar Concentrators
by Qi Nie, Wenqing Li and Xiao Luo
Photonics 2024, 11(6), 553; https://doi.org/10.3390/photonics11060553 (registering DOI) - 12 Jun 2024
Abstract
Quantum-cutting luminescent solar concentrators (QC-LSCs) have great potential to serve as large-area solar windows. These QC nanocrystals can realize a photoluminescence quantum yield (PLQY) of as high as 200% with virtually zero self-absorption loss. Based on our previous work, we have constructed a [...] Read more.
Quantum-cutting luminescent solar concentrators (QC-LSCs) have great potential to serve as large-area solar windows. These QC nanocrystals can realize a photoluminescence quantum yield (PLQY) of as high as 200% with virtually zero self-absorption loss. Based on our previous work, we have constructed a Monte Carlo simulation model that is suitable to simulate the performance of the QC-LSCs, which can take into account the band-edge emissions and near-infrared emissions of the QC-materials. Under ideal PLQY conditions, CsPbClxBr3−x:Yb3+-based LSCs can reach 12% of the size-independent external quantum efficiency (ηext). Even if LSCs have a certain scattering factor, the CsPbClxBr3−x:Yb3+-based LSCs can still obtain an ηext exceeding 6% in the window size (>1 m2). The flux gain (FG) of the CsPbClxBr3−x:Yb3+-based LSC-PV system can reach 14 in the window size, which is a very encouraging result. Full article
(This article belongs to the Special Issue New Insights in Low-Dimensional Optoelectronic Materials and Devices)
Show Figures

Figure 1

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop