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Mitigation of graft-versus-host disease in rats treated with allogeneic and xenogeneic antilymphocytic sera

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Summary

The survival of rats receiving a sublethal dose of CY and grafted with allogeneic bone marrow, was prolonged by treatment with either allogeneic or xenogeneic anti-lymphocytic sera. These seem to prevent a fatal GVHD while allowing a temporary ‘take’ of the graft.

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Authors and Affiliations

  1. Transplantation Immunology Unit, Division of Immunology and Allergy, Hôpital cantonal, 64 Avenue de la Roseraie, CH-1211, Genève, Switzerland

    Christiane Werner, Elbe Ramirez, C. Gervasoni & M. Jeannet

Authors
  1. Christiane Werner
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  2. Elbe Ramirez
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  3. C. Gervasoni
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  4. M. Jeannet
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Additional information

This work was supported by Grant No. FOR 007. AK. 72 from the Ligue Suisse contre le Cancer and Grant No. 3.8580.72 from the Fonds National Suisse de la Recherche Scientifique.

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Werner, C., Ramirez, E., Gervasoni, C. et al. Mitigation of graft-versus-host disease in rats treated with allogeneic and xenogeneic antilymphocytic sera. Experientia 32, 241–242 (1976). https://doi.org/10.1007/BF01937788

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  • DOI: https://doi.org/10.1007/BF01937788

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