Abstract
The virally encoded oncogenes (v-onc) of avian and mammalian retroviruses are the recombinant products of normal cellular genes (c-onc) and a retro viral genome1,2. These cellular homologues have been highly conserved during evolution and are found in human DNA1,2. The expression of at least one c-onc under the control of a viral promoter results in transformation of cells in a manner resembling that displayed by the v-onc counterpart3; the inappropriate expression of c-onc in the absence of viral influences could likewise result in the malignant state4. This proposal would be strongly supported by the presence of c-onc RNAs in a variety of human tumours were they not also demonstrable in normal tissues5–7. The role of these RNAs in the oncogenic process remains unclear. Here we report that RNA homologous to the oncogene (v-abl) of Abelson murine leukaemia virus (A-MLV) is expressed in a unique human leukaemia in a fashion different from that of other human tissues and tumours. In addition, DNA from this tumour transforms NIH-3T3 cells at a high efficiency in a transfection assay. The transfected sequences are not related to the v-abl gene, but the NIH-3T3 transformants manufacture a transforming growth factor which behaves similarly to factors produced by A-MLV-transformed NIH-3T3 fibroblasts.
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Ozanne, B., Wheeler, T., Zack, J. et al. Transforming gene of a human leukaemia cell is unrelated to the expressed tumour virus related gene of the cell. Nature 299, 744–746 (1982). https://doi.org/10.1038/299744a0
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DOI: https://doi.org/10.1038/299744a0
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