Abstract
IN the course of examining inflammatory exudate for substances capable of acting as mediators of increased capillary permeability it was found that in pleural exudates collected from rats within an hour of intrapleural injection of 0.1 ml. turpentine there were significant amounts of 5-hydroxytryptamine. Since then, similar exudate collected 30 min. after injury has been found to contain 1–3 µgm. 5-hydroxytryptamine/ml. One hour after injection this value has fallen to 0.2 µgm./ml. or less. 30-min. exudates contain less than 0.5 µgm. of histamine.
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SPECTOR, W., WILLOUGHBY, D. 5-Hydroxytryptamine in Acute Inflammation. Nature 179, 318 (1957). https://doi.org/10.1038/179318a0
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DOI: https://doi.org/10.1038/179318a0
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