Abstract
THE microsome fraction of rat liver parenchymatous cells has been shown to contain tissue-specific antigens1,2. These antigens are gradually lost from the cell during the course of carcinogenesis, the hepatoma cell being virtually devoid of them3,4. Thus they constitute an important difference between normal and cancer cells and offer a possibility for investigating the mechanism of de-differentiation that is linked with the property of uncontrolled growth. This communication is concerned with the identification of the subcellular structures which are involved in the immunological change.
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VOGT, P. Distribution of Tissue-Specific Antigens in Centrifugal Fractions of Rat Liver. Nature 182, 1807–1808 (1958). https://doi.org/10.1038/1821807a0
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DOI: https://doi.org/10.1038/1821807a0
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