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Prediction of retention of O-ethyl, O-aryl and N-isopropyl phosphoroamidothioates in RP-HPLC from molecular structure parameters

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Summary

Multi-variable regression analysis between lnkw, c (in retention equation lnk′=lnkw+cCb) and molecular structure parameters, including hydrophobicity, electric effect, field effect and position-specific effect constant, was carried out with O-ethyl, O-aryl and N-isopropyl phosphoroamidothioates as test solutes. With these quantitative relationships, the retention behaviour of these solutes for different mobile phase compositions was predicted. The results showed that there are only 26.7% of total, experimentally measured, capacity factors with relative deviations larger than 5% and only 2.2% with deviations larger than 10%, which means that it is possible to apply the method reported to predict retention values for qualitative purposes for different mobile phase compositions.

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Authors and Affiliations

  1. Dalian Chromatographic R&D Center of China, Dalian Institute of Chemical Physics, Academia Sinica, 116011, Dalian, P.R. China

    H. F. Zou, Y. K. Zhang & P. C. Lu

  2. Institute of Elemento-Organic Chemistry, Nankai University, Tanjing, P.R. China

    Q. S. Wang, R. Y. Gao, H. Z. Yang & B. W. Yang

Authors
  1. H. F. Zou
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  2. Q. S. Wang
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  3. R. Y. Gao
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  4. H. Z. Yang
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  5. B. W. Yang
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  6. Y. K. Zhang
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  7. P. C. Lu
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Zou, H.F., Wang, Q.S., Gao, R.Y. et al. Prediction of retention of O-ethyl, O-aryl and N-isopropyl phosphoroamidothioates in RP-HPLC from molecular structure parameters. Chromatographia 31, 143–146 (1991). https://doi.org/10.1007/BF02274562

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  • DOI: https://doi.org/10.1007/BF02274562

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