Summary
Our concept of nucleic acid replication does not explain the movement in that process—i.e., the existence of a socalled “growing point”. This omission may manifest itself in a failure to understand primitive nucleic acid replication. The latter may not be merely a “templating” process. Primitive nucleic acid replication is postulated to involve a particular type of peptide that establishes a “growing point”—a polypeptide in whichalternate amino acid residues are basic. Possible interactions of such a peptide with single and double stranded nucleic acid and its possible mode(s) of synthesis in a primitive environment are discussed.
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Woese, C.R. Evolution of nucleic acid replication: The possible role of simple repeating sequence polypeptides therein. J Mol Evol 2, 205–208 (1973). https://doi.org/10.1007/BF01654001
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DOI: https://doi.org/10.1007/BF01654001