Skip to main content
Log in

Localization of the gene for human erythrocyte glycophorin C to chromosome 2, q14–q21

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

A complementary cDNA clone (900 bp) representing the 3′ untranslated region and almost the entire coding sequence of the human erythrocyte membrane glycophorin C has been used to determine the chromosomal location of the blood group Gerbich locus by in situ hybridization. The results indicate that this locus is assigned to the region q14–q21 of chromosome 2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Anderson RA, Marchesi VT (1985) Regulation of the association of membrane skeletal protein 4.1 with glycophorin by a polyphosphoinositide. Nature 318: 295–298

    Google Scholar 

  • Anstee DJ (1981) The blood group MNSs-active sialoglycoproteins. Semin Hematol 18: 13–31

    Google Scholar 

  • Anstee DJ, Parsons SF, Ridgwell K, Tanner MJA, Merry AH, Thomson EE, Judson PA, Johnson P, Bates S, Fraser ID (1984a) Two individuals with elliptocytic red cells apparently lack three minor erythrocyte membrane sialoglycoproteins. Biochem J 218: 615–619

    Google Scholar 

  • Anstee DJ, Ridgwell K, Tanner MJA, Daniels GL, Parsons SF (1984b) Individuals lacking the Gerbich blood group antigen have alterations in the human erythrocytes membrane sialoglycoproteins β and γ. Biochem J 221: 97–104

    Google Scholar 

  • Bennet V (1985) The membrane skeleton of human erythrocytes and its implications for more complex cells. Annu Rev Biochem 54: 273–304

    Google Scholar 

  • Camargo M, Cervenka J (1982) Patterns of DNA replication of human chromosomes. II. Replication map and replication model. Am J Hum Genet 34: 757–780

    Google Scholar 

  • Colin Y, Rahuel C, London J, Romeo PH, d'Auriol L, Galibert F, Cartron JP (1986) Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C. J Biol Chem 261: 229–233

    Google Scholar 

  • Cook PJL, Lindenbaum RH, Salonen R, De la Chapelle A, Daker MG, Buckton KE, Noades JE, Tippett P (1981) The MNSs blood group of families with chromosome 4 rearrangements. Ann Hum Genet 45: 39–47

    Google Scholar 

  • Dahr W, Moulds J, Baumeister G, Moulds M, Kiedrowski S, Hummel M (1985) Altered membrane sialoglycoproteins in human erythrocytes lacking the Gerbich blood group antigens. Biol Chem Hoppe-Seyler 366: 201–211

    Google Scholar 

  • ISCN: An international system for human cytogenetic nomenclature (1978) Report of the standing committee on human cytogenetic nomenclature. Cytogenet Cell Genet 21: 313–404

    Google Scholar 

  • Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manuel. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

    Google Scholar 

  • Mattei MG, Philip N, Passage E, Moisan JP, Mandel JL, Mattei JF (1985) DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome. Hum Genet 69: 268–271

    Google Scholar 

  • Mueller TJ, Morrison M (1981) In: Kruckeberg WC, Eaton JN (eds) Erythrocyte membranes 2: recent clinical and experimental advances. Liss, New York, pp 95–112

    Google Scholar 

  • Oppenheim JJ, Kovacs EJ, Matsushima K, Durum SK (1986) There is more than one interleukin-1. Immunology today 7: 45–56

    Google Scholar 

  • Pasvol G, Anstee DJ, Tanner MJA (1984) Glycophorin C and the invasion of red cells by Plasmodium falciparum. Lancet I: 907–908

    Google Scholar 

  • Povey S, Morton NE, Sherman SL (1985) Report of the Committee on the genetic constitution of chromosome 2. Cytogenet Cell Genet 40: 67–106

    Google Scholar 

  • Talmadge K, Gilbert W (1980) Construction of plasmid vectors with unique PstI cloning sites in a signal sequence coding region. Gene 12: 235–241

    Google Scholar 

  • Webb AC, Collins KL, Auron PE, Eddy RL, Nakai H, Byers M, Shows TB (1985) The gene for interleukin-1 (IL-1) is on human chromosome 2 at q13–q21. Cytogenet Cell Genet 40: 774

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mattei, M.G., Colin, Y., Le Van Kim, C. et al. Localization of the gene for human erythrocyte glycophorin C to chromosome 2, q14–q21. Hum Genet 74, 420–422 (1986). https://doi.org/10.1007/BF00280497

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00280497

Keywords

Navigation