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Der Einfluß von Dimethylsulfoxid auf die Permeabilität der Lysosomenmembran bei quantitativer und qualitativer Darstellung der sauren Phosphatase

Dimethylsulfoxid induced permeability changes of the lysosomal membranes studied by quantitative and qualitative acid phosphatase techniques

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Summary

The effect of dimethylsulfoxid on the acid phosphatase reaction was studied by quantitative biochemical and histochemical techniques. Slices and homogenates of rat liver showed increased activity. The results suggest that dimethylsufoxid enhances the biological permeability of lysosomal membranes.

Zusammenfassung

Der Einfluß von Dimethylsulfoxid auf die quantitative biochemische und histochemische Darstellung der sauren Phosphatase der Rattenleber wurde untersucht. Sowohl histochemisch an Schnittpräparaten als auch quantitativ in Gewebshomogenaten können intensivere bzw. höhere Enzymaktivitäten beobachtet werden. Dies läßt darauf schließen, daß Dimethylsulfoxid die Permeabilität der Lysosomenmembranen erhöht.

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Authors and Affiliations

  1. Pathologisches Institut der Universität Basel, Switzerland

    Eugen S. Gander & Jakob M. Moppert

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  1. Eugen S. Gander
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  2. Jakob M. Moppert
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Gander, E.S., Moppert, J.M. Der Einfluß von Dimethylsulfoxid auf die Permeabilität der Lysosomenmembran bei quantitativer und qualitativer Darstellung der sauren Phosphatase. Histochemie 20, 211–214 (1969). https://doi.org/10.1007/BF00306008

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  • DOI: https://doi.org/10.1007/BF00306008

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