Summary
Nine elderly and 11 young hypertensives underwent continuous ambulatory monitoring of blood pressure (BP), assessment of cardiovascular reflexes and M-mode echocardiography as hospital in-patients prior to treatment with once-daily indapamide (2.5 mg). They were followed as out-patients for 4 months during which time casual BP was measured at monthly intervals. The patients were then readmitted to hospital and studied using the same protocol under similar standardised conditions. The results showed that indapamide reduced casual and ambulatory BP in both young and elderly although the most marked effect was seen on systolic BP. Assessment of cardiovascular reflexes indicates that at least part of the hypotensive action of indapamide is due to a diuretic effect. Treatment with indapamide has comparable results on both young and elderly.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Turner P (1981) Introduction: Indapamide. Postgrad Med J 57 (Suppl 2): 5
Campbell DB, Moore RA (1981) The pharmacology and clinical pharmacology of indapamide. Postgrad Med J 57 (Suppl 2): 7–17
Andries EW, Brems HM, Clement DL (1977) Effect of indapamide on blood pressure in patients with essential hypertension: preliminary results of a multicentre trial. Curr Med Res Opin 5 (Suppl 1): 165–167
Dunn FG, Hillis WS, Tweddel A, Rae AP, Lorimer AR (1981) Non-invasive cardiovascular assessment of indapamide in patients with essential hypertension. Postgrad Med J 57 (Suppl 2): 19–22
Van Hee W, Thomas J, Brems H (1981) Indapamide in the treatment of essential arterial hypertension in the elderly. Postgrad Med J 57 (Suppl 2): 29–33
Littler WA, Honour AJ, Sleight P, Stott FD (1972) Continuous recording of direct arterial pressure and electrocardiogram in unrestricted man. Brit Med J 3: 76–78
Watson RDS, Stallard TJ, Littler WA (1979) Influence of once-daily administration of β-adrenoreceptor antagonists on arterial pressure and its variability. Lancet 1: 1210–1212
Smyth HS, Sleight P, Pickering TG (1969) Reflex regulation of arterial pressure during sleep in man: a quantitative assessment of assessing baroreflex sensitivity. Circ Res 24: 109–121
Waite MA (1973) Measurement of concentration of angiotensin 1 in human blood by radio-immunoassay. Clin Sci 45: 51–64
Peuler JD, Johnson GA (1977) Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. Life Sci 21: 625–636
Rowlands DB, Glover DR, Ireland MA, McLeay RAB, Stallard TJ, Watson RDS, Littler WA (1982) Assessment of left ventricular mass and its response to antihypertensive treatment. Lancet 1: 467–470
Watson RDS, Stallard TJ, Flinn RM, Littler WA (1980) Factors determining direct arterial pressure and its variability in hypertensive man. Hypertension 2: 333–341
Bowker CH, Murphy MA (1981) A multicentre open trial of indapamide in general practice. Postgrad Med J 57 (Suppl 2): 53–56
Gould BA, Mann S, Davies AB, Raftery EB (1981) Does placebo lower blood pressure? Lancet 2: 1377–81
Burgess CD, McKee CEL, Wilson CA, Warren DJ (1981) The effect of indapamide on muscle blood flow in hypertensive patients. Postgrad Med J 57 (Suppl 2): 23–25
Gargouil YM, Mironneau J (1977) Effects of indapamide in excitation-contraction coupling in smooth muscle of a mammalian portal vein. Curr Med Res Opin 5 (Suppl 1): 55–58
Haiat R, Lellouch A, Lanfranch J, Witchitz S (1981) Continuous electrocardiographic recording (Holter method) during indapamide treatment: a study of 40 cases. Postgrad Med J 57 (Suppl 2): 68–69
Gribbin B, Pickering TG, Sleight P, Peto R (1971) Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 29: 424–431
Angell-James JE (1974) Pathophysiology of aortic baroreceptors in rabbits with experimental atherosclerosis. Circ Res 34: 27–39
Caird FI, Andrews GB, Kennedy RD (1973) Effect of posture on blood pressure in the elderly. Br Heart J 35: 527–530
Johnson RH, Smith AC, Spalding JMK, Woolner L (1965) Effect of posture on blood pressure in elderly patients. Lancet 1: 731–733
Jackson G, Piercianowski TA, Mahon W, London J (1976) Inappropriate anti-hypertensive therapy in the elderly. Lancet 2: 1317–18
Horgan JH, O'Donovan A, Teo KK (1981) Echocardiographic evaluation of left ventricular function in patients showing an anti-hypertensive and biochemical response to indapamide. Postgrad Med J 57 (Suppl 2): 64–67
Mimran A, Zambrowski JJ, Coppolani T (1981) The antihypertensive action of indapamide: results of a French multicentre study of 2184 ambulant patients. Postgrad Med J 57 (Suppl 2): 60–63
Weidmann P, Grimm M, Meier A, Keusch G, Glück Z, Beretta-Picolli C (1981) Studies of the antihypertensive mechanism of indapamide in man. Postgrad Med J 57 (Suppl 2): 18
Teicholz LE, Kreulen T, Herman MV, Gorlin R (1976) Problems in echocardiographic volume determinations: echocardiographic-angiocardiographic correlations in the presence of asynergy. Am J Cardiol 37: 7–11
Rowlands DB, Glover DR, Stallard TJ, Littler WA (1982) Control of blood pressure and reduction of echocardiographically assessed left ventricular mass with once-daily Timolol. Br J Clin Pharmacol 14: 89–95
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rowlands, D.B., Glover, D.R., Young, M.A. et al. Once daily indapamide in the treatment of the elderly and young hypertensive. Eur J Clin Pharmacol 27, 397–405 (1984). https://doi.org/10.1007/BF00549585
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00549585