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Pharmacokinetics and tolerance of slow-release indomethacin tablets in rheumatoid arthritis

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Summary

The pharmacokinetics, efficacy and tolerance of a new formulation of slow-release indomethacin tablet were compared with those of a conventional indomethacin capsule in 30 patients with rheumatoid arthritis. The slow-release tablet was absorbed more slowly than the capsule (tmax 3.7 h and < 2 h, respectively) and produced more even serum drug levels in 10 subjects. Side-effects, especially dizziness and diarrhoea, were less frequent after the slow-release tablet than during the capsule period.

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Authors and Affiliations

  1. Rheumatism Foundation Hospital, Heinola, Finland

    K. Kaarela, K. Lehtinen, P. Mäkisara, K. Holttinen, Ulla Lamminsivu & A. Gordin

  2. Orion Pharmaceutical Company, Research Laboratories, Helsinki, Finland

    K. Kaarela, K. Lehtinen, P. Mäkisara, K. Holttinen, Ulla Lamminsivu & A. Gordin

Authors
  1. K. Kaarela
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  2. K. Lehtinen
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  3. P. Mäkisara
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  4. K. Holttinen
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  5. Ulla Lamminsivu
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  6. A. Gordin
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Kaarela, K., Lehtinen, K., Mäkisara, P. et al. Pharmacokinetics and tolerance of slow-release indomethacin tablets in rheumatoid arthritis. Eur J Clin Pharmacol 23, 349–351 (1982). https://doi.org/10.1007/BF00613619

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  • DOI: https://doi.org/10.1007/BF00613619

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