Summary
CSF from a patient with congential indifference to pain was found to produce analgesia in the rat following intracerebroventricular injections. The analgesic effect was attenuated by pretreatment with naloxone suggesting the involvement of hyperactive endogenous opiate mechanisms in this patient.
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Fabbri, A., Fraioli, F., Cruccu, G. et al. Intracerebroventricular injection of cerebrospinal fluid (CSF) from a patient with congenital indifference to pain induces analgesia in rats. Experientia 40, 1365–1366 (1984). https://doi.org/10.1007/BF01951891
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DOI: https://doi.org/10.1007/BF01951891