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Primary cancer of the liver in rats after subcutaneous implantation of pellets of progesterone and testosterone propionate

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Résumé

Le carcinome hépatocellulaire du type trabéculaire a paru dans 2 rats sur 5, 745 jours après l'implantation de boulettes de progestérone cristallin et de propionate de testostérone, pesant 8 à 10 mg chacune. Un de ces rats a développé un carcinome provenant de l'épithélium d'une bronchiole respiratoire. L'absence d'une cholangiofibrosite antécédente, d'une nécrose ou d'une cirrhose hors de l'endroit de la tumeur du foie chez les rats soumis aux épreuves expérimentales, peut nécessiter un nouvel examen de la signification des lésions hépatiques comme facteur prédisposant au cancer chez l'homme.

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Authors and Affiliations

  1. C. S. I. R. University Nutrition Research Unit and the Departments of Physiology and Anatomy, University of the Witwatersrand, Johannesburg, South Africa

    J. Gillman & Christine Gilbert

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  1. J. Gillman
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  2. Christine Gilbert
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Gillman, J., Gilbert, C. Primary cancer of the liver in rats after subcutaneous implantation of pellets of progesterone and testosterone propionate. Experientia 13, 160–161 (1957). https://doi.org/10.1007/BF02158149

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