Abstract
IT seems likely that the most interesting pharmacological properties of the natural alkaloid reserpine are mainly determined by three chemical groups in the molecule : (1) the β-indolylethylamine group, which is present in many other natural drugs (serotonine, ergot alkaloids) ; (2) a tertiary nitrogen atom which is substituted by three carbon chains, one of which (the ethyl group) is attached to the indole nucleus, while the other two form part of a ring system bearing (3) a hydroxyl group which is esterified by trimethoxybenzoic acid. The β-phenylethylamine group, which is very similar to the β-indolylethylamine group, is found in another group of drugs, the adrenaline family.
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KRALT, T., MOED, H., CLAASSEN, V. et al. Reserpine Analogues. Nature 188, 1108–1109 (1960). https://doi.org/10.1038/1881108b0
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DOI: https://doi.org/10.1038/1881108b0
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