Abstract
WE have already shown1–6 the existence in the animal organism of a reflex-humoral protective system which prevents the coagulation of blood circulating in the vascular system. In connexion with these results we became interested in the work of Wil-gram7,8 as well as in that of Thomas and Hartroft9. These authors have observed spontaneous myocardial infarctions in rats kept for several months on a diet enriched with fat and cholesterol. We supposed the diet indicated to produce a negative influence on the functional condition of the physiological anticoagulating system, due to which fact a pre-thrombotic state is seen to arise in the animal organism.
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References
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KUDRJASHOV, B., BAZASIAN, G., SYTINA, N. et al. Experimental Pre-Thrombotic State of an Organism resulting from the Dysfunction of the Physiological Anticoagulating System induced by an Atherogenic Diet. Nature 189, 67–68 (1961). https://doi.org/10.1038/189067a0
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DOI: https://doi.org/10.1038/189067a0
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