Abstract
Exposure to vanadium (V), which is a toxic element widely distributed in nature, is of increasing concern because of its occurrence in various fossil fuels. The distribution of V in selected tissues of male Swiss-Webster mice was investigated at different time intervals following a single intraperitoneal dose of two mg V/kg. The highest amounts of V were observed in the kidney at one day, whereas after one day, bone showed the highest levels of all tissues. Levels of V in liver were equal to those in the kidney at two days after the administration but were significantly higher than kidney after this period. In most tissues, there was a rapid decline of V residues, which was not necessarily log-linear in fashion. The spleen showed a significant increase in V from 5 to 12 days after the administration. Groups of mice were injected intraperitoneally with doses ranging from 0.1 to 8 mg V/kg and tissues were collected after 1 and 5 days. At one day after injection, most tissues showed higher amounts of V at dose levels of 5 mg/kg than would be expected from a linear dose-dependent relationship. At 5 days, all tissues showed a linear dose-concentration relationship. The tissue: blood ratios indicated that at one day after injection there was an increased accumulation of V in tissues with increased dose. At five days after injection, the tissue:blood ratios were greater than unity for all tissues except brain. The increased accumulation of V in tissues with increased dose observed at one day was not observed at five days.
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Parker, R.D.R., Sharma, R.P. & Oberg, S.G. Distribution and accumulation of vanadium in mice tissues. Arch. Environ. Contam. Toxicol. 9, 393–403 (1980). https://doi.org/10.1007/BF01055291
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DOI: https://doi.org/10.1007/BF01055291