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Effect of actinomycin-D on bone mineral metabolism in rats

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Abstract

Actinomycin-D, when given to rats, decreased the plasma calcium level, increased the retention of85Sr in the whole body and plasma but not in bone. The findings suggest that Actinomycin-D interferes with bone resorption but not with the mineralization process.

Résumé

Actinomycin-D, chez des rats, baissait le plasma calcium, augmentait la retention du85Sr totale et dans le plasma, mais n'influence pas la retention du85Sr dans l'os. Cettes observations indiquent qu'Actinomycin-D empeche la resorbtion de l'os, mais ne derange pas le processus de la minéralisation.

Zusammenfassung

Actinomycin-D, bei Ratten gegeben, senkte den Calciumspiegel im Plasma und erhöhte die Retention von85Sr im Körper und im Plasma, nicht dagegen in den Knochen. Diese Ergebnisse lassen vermuten, daß Actinomycin-D in den Prozeß der Knochenresorption, nicht dagegen in den der Mineralisierung eingreift.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Malmö General Hospital, University of Lund, Malmö, Sweden

    Anders G. Hulth &  Bo E. Nilsson

Authors
  1. Anders G. Hulth
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  2. Bo E. Nilsson
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Additional information

Financial support was obtained from The Swedish Medical Research Council, No K67-17X-111-03, and Hans & Loo Ostermans Foundation.

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Hulth, A.G., Nilsson, B.E. Effect of actinomycin-D on bone mineral metabolism in rats. Calc. Tis Res. 3, 194–197 (1969). https://doi.org/10.1007/BF02058662

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  • DOI: https://doi.org/10.1007/BF02058662

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