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Missing Y chromosome in juvenile chronic myelogenous leukemia

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Summary

A child with Ph1-negative juvenile chronic myelogenous leukemia (CML) is presented. The only chromosomal abnormality in hematopoietic tissues consisted of an absent Y chromosome. While a missing Y chromosome in adult patients with CML may be associated with a better prognosis, the clinical course in our patient was as malignant as that usually observed in other children with Ph1-negative juvenile CML.

This publication is No. 626 from the Department of Biophysics and Genetics, University of Colorado Medical Center.

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Authors and Affiliations

  1. Department of Biophysics/Genetics and Pediatrics, University of Colorado Medical Center, National Jewish Hospital, Denver, Colorado

    Taru Hays, James R. Humbert, David C. Peakman, John J. Hutter, Helvise G. Morse, Arthur Robinson & Charles S. August

  2. the Oncology Center of Denver Children's Hospital, Denver, Colorado

    Taru Hays, James R. Humbert, David C. Peakman, John J. Hutter, Helvise G. Morse, Arthur Robinson & Charles S. August

Authors
  1. Taru Hays
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  2. James R. Humbert
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  3. David C. Peakman
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  4. John J. Hutter
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  5. Helvise G. Morse
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  6. Arthur Robinson
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  7. Charles S. August
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Additional information

Supported in part by the following Public Health Service Grants: Research Grants CA-15564-01, CA-12247, and CA-13419 from the National Cancer Institute, by a general Research Support Grant No. RR-05357 and by Grant No. HD-00622 from the National Institute of Child Health and Human Development, by funds provided by the House Bill No. 1578 of the State of Colorado Legislature (Sickle Cell Anemia Treatment and Research Center) and by a Biological Medical Award from the Swiss Academy of Medical Sciences.

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Hays, T., Humbert, J.R., Peakman, D.C. et al. Missing Y chromosome in juvenile chronic myelogenous leukemia. Hum Genet 29, 259–264 (1975). https://doi.org/10.1007/BF00297633

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  • DOI: https://doi.org/10.1007/BF00297633

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