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Biological damage in testis by Iodine-125 in partially blocked thyroid of rats

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Summary

Degeneration of testis has been observed after administration of Iodine-125 in potassiumperchlorate treated rats. Histological damage is associated with loss of DNA, RNA, acid phosphatase, total adenosine triphosphatase (ATPase) and Na/K dependent ATPase. Iodine-125 induced atrophic testis shows higher content of sodium and lower levels of potassium as compared to control testis. Damage of testis by Iodine-125 has been compared with atrophied testis, following gamma irradiation earlier reported. Auger effect due to Iodine-125 decay and transmutation at the sites of nuclei and plasma membrane of germinal cells seems to be the possible explanation for testicular damage caused by Iodine-125.

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References

  1. Anber, M., Guttman, S., Lewitus, Z.: The mode of action of perchlorate ions on the iodine uptake of thyroid gland. Int. J. appl. Radiat.7, 86–96 (1959)

    Google Scholar 

  2. Auger, P.: L'effect photoelectrique compose. Ann. Phys.10, 183 (1926)

    Google Scholar 

  3. Carlson, T. A., White, M: Explosion of multicharged molecular ions: Chemical consequences of inner shell vacancies in atoms. Proc. Symp. on chemical effects of nuclear transformations, Vol. 1, p. 23. Vienna, 1965

    Google Scholar 

  4. Doniach, I., Shale, D. J.: Biological effects of131I and125I isotopes of iodine in the rat. J. Endocr.71, 109–114 (1976)

    Google Scholar 

  5. Ellis, L. C.: Radiation effects. In: The testis, Vol. III, pp. 333–376 (Johnson, A. D., Gomes, W. R., VanDemark, N. L., Eds.). New York: Academic Press 1970

    Google Scholar 

  6. Ertl, H. H., Feinendegen, L. E., Heiniger, H.: Iodine-125, a tracer in cell biology: Physical properties and biological aspects. Phys. Med. Biol.15, 447–456 (1970)

    Google Scholar 

  7. Feinendegen, L. E.: Biological damage from Auger effect. Possible benefits. Rad. and Environm. Biophys.12, 85–99 (1975)

    Google Scholar 

  8. Gomes, W. R.: Metabolic and regulatory hormones influencing testis function. In: The testis, Vol. III, pp. 68–138 (Johnson, A. D., Gomes, W. R., VanDemark, N. L., Eds.). New York: Academic Press 1970

    Google Scholar 

  9. Gupta, G. S.: Radiation effects on rat testis. Evidences for Na/K stimulated ATPase in germinal and non-germinal cells of testis of rat. Ind. J. Biochem. Biophys.12, 189–192 (1975)

    Google Scholar 

  10. Gupta, G. S., Bawa, S. R.: Radiation effects on rat testes. V. Studies on lysosomal enzymes (acid phosphatase and acid DNAse) and their physiological significance following partial bodyγ-irradiation. J. Reprod. Fertil.44, 223–233 (1975)

    Google Scholar 

  11. Gupta, G. S., Bawa, S. R.: Radiation effects on testes. VI. 5′nucleotidase and adenosine triphosphatase following partial body gamma irradiation. Radiobiol. Radiother.16, 221–234 (1975)

    Google Scholar 

  12. Gupta, G. S., Bawa, S. R.: Radiation effects on testes. VII. Alterations in nucleic acids and P32 incorporation after local body gamma irradiation. Strahlentherapie149, 324–332 (1975)

    Google Scholar 

  13. Gupta, G. S., Bawa, S. R.: Radiation effects on testes. X. Studies on inorganic pyrophosphatase and pyrophosphate following partial body gamma irradiation of rats. Radiat. Res.60 (in press) (1977)

  14. Gupta, G. S., Bawa, S. R.: Radiation effects on testes. XII. Monovalent electrolytes in relation to radiation injury of germinal epithelium. Radial. Res. (in press) (1977)

  15. Hofer, K. G., Warters, R. L., Harris, C. R., Smith, J. M.: Radiotoxicity of Auger emitters incorporated into different subcellular compartments. Abstract in Proc. Int. Conf. on molecular and microdistribution of radioisotopes and biological consequences, Jülich (Germany), 1975

  16. Krisch, R. E., Zelle, M. R.: Biological effects of radioactive decay: The role of transmutation effect. Advanc. Rad. Biol.3, 177–213 (1969)

    Google Scholar 

  17. Okada, S.: Radiation biochemistry, Vol. I, Cells. New York: Academic Press 1970

    Google Scholar 

  18. VanDemark, N. L., Free, M. J.: Temperature effects. In: The testis, Vol. III, pp. 233–312 (Johnson, A. D., Gomes, W. R., VanDemark, N. L., Eds.). New York: Academic Press 1970

    Google Scholar 

  19. Wolff, J.: Transport of iodide and other anions in the thyroid gland. Physiol. Rev.44, 45–90 (1964)

    Google Scholar 

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Authors and Affiliations

  1. Department of Biophysics, Panjab University, 160014, Chandigarh, India

    G. S. Gupta & V. K. Chopra

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  1. G. S. Gupta
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  2. V. K. Chopra
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Gupta, G.S., Chopra, V.K. Biological damage in testis by Iodine-125 in partially blocked thyroid of rats. Radiat Environ Biophys 14, 147–152 (1977). https://doi.org/10.1007/BF01332150

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  • DOI: https://doi.org/10.1007/BF01332150

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