Summary
In a double-blind crossover study performed at Wood Veterans Administration Center and Milwaukee County General Hospital, the efficacy of ethoheptazine (Zactane®) as an analgesic agent was compared to dextropropoxyphene (65 mg) and placebo. Single oral doses of 150 mg ethoheptazine citrate were administered to 76 patients with chronic pain of various etiologies. The analgesia score obtained for 150 mg ethoheptazine was not significantly different from that obtained for 65 mg dextropropxyphene HCl. Both active medications demonstrated significant analgesic activity compared to placebo. Side effects were minor and did not interfere with the course of therapy.
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Wang, R.I.H. A controlled clinical comparison of the analgesic efficacy of ethoheptazine, propoxyphene and placebo. Eur J Clin Pharmacol 7, 183–185 (1974). https://doi.org/10.1007/BF00560379
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DOI: https://doi.org/10.1007/BF00560379