Summary
A controlled study of the clinical pharmacology of the biliary tract has been made. The rate of gallbladder emptying induced by a fatty meal was taken as a parameter for assessment of the inhibitory effect of indoprofen, a new analgesic-anti-inflammatory drug, pentazocine and morphine. The compounds were administered as single doses by iv (indoprofen and pentazocine) or im (morphine) injection. Indoprofen up to 400 mg had no effect, whereas morphine and pentazocine exerted a significant inhibitory effect on emptying of the gallbladder. Adverse reactions of clinical significance were associated with morphine and pentazocine, but were negligible with indoprofen.
Similar content being viewed by others
References
Armitage, P.: Statistica Medica. Milano: Feltrinelli 1975
Baldrighi, G., Sacchetti, G.: Studio preliminare di emodinamica in pazienti cardiopatici trattati con dose unica endovena di indoprofene. Clin. Ter. (in press)
Beaver, W.T., Wallenstein, S.L., Houde, R.W., Rogers, A.: A comprison of the analgesic effects of pentazocine and morphine in patients with cancer. Clin. Pharmacol. Ther.7, 740–751 (1966)
Beckett, A.H., Kourounakis, P., Vaugham, D.P., Mitchard, M.: The absorption, blood concentrations and excretion of pentazocine after oral, intramuscular or rectal administration to man. J. Pharm. Pharmacol.22, suppl. 169S-174S (1970)
Bellville, J.W., Forrest, W.H.: Respiratory and subjective effects of d- and l-pentazocine. Clin. Pharmacol. Ther.9, 142–151 (1968)
Bliss, C.I.: Statistics in biology, Vol. I, New York: McGraw-Hill 1967
Buttinoni, A., Cuttica, A., Franceschini, J., Mandelli, V., Orsini, G., Passerini, N., Turba, C., Tommasini, R.: Pharmacological study on a new analgesic-anti-inflammatory drug: α[-4-(1-oxo-2-iso-indolinyl)-phenyl]-propionic acid or K 4277. Arzneimittel-Forsch.,23, 1100–1107 (1973)
Economou, G., Ward-Mc Quaid, J.N.: A cross-over comparison of the effect of morphine, pethidine, pentazocine, and phenazocine on biliary pressure. Gut12, 218–221 (1971)
Finney, J.D.: Statistical method in biological assay. London: Griffin 1952
Fuccella, L.M., Conti, F., Corvi, G., Mandelli, V., Randelli, M., Stefanelli, G.: Double-blind study of the analgesic effect of indoprofen (K 4277) in man. Clin. Pharmacol. Ther.17, 277–283 (1975)
Fuccella, L.M., Goldaniga, G.C., Moro, E., Tamassia, V., Tosolini, G.P., Valzelli, G.: Fate of the analgesic and anti-inflammatory drug K 4277 after oral administration to man. Europ. J. clin. Pharmacol.6, 256–260 (1973)
Lee, G., DeMaria, A.N., Realyvasquez, F., Mason, D.T., Amsterdam, E.A.: Comparative hemodynamic effects of morphine, meperidine and pentazocine following acute myocardial infarction in man. Amer. J. Cardiol.35, 151 (1975)
Loan, W.B., Morrison, J.D.: Strong analgesics: pharmacological and therapeutic aspects. Drugs5, 108–142 (1973)
Nannini, G., Giraldi, P.N., Molgora, G., Biasoli, G., Spinelli, G., Logemann, W., Dradi, E., Zanni, G., Buttinoni, A., Tommasini, R.: New analgesic-anti-inflammatory drugs. 1-Oxo-2-substituted isoindoline derivatives. Arzneimittel-Forsch.23, 1090–1100 (1973)
Payne, J.P.: The clinical pharmacology of pentazocine. Drugs5, 1–5 (1973)
Pedronetto, S., Gorini, F., Mandelli, V., Fuccella, L.M.: Double-blind trial of the new analgesic and anti-inflammatory drug, indoprofen in post-episiotomic pain. J. int. med. Res.3, 16–20 (1975)
Sacchetti, G., Caputo, G., Mandelli, V., Fornari, R., Magni, E.: Biliary colic as a model for assessing analgesic activity in humans. In preparation.
Sacchetti, G., Mandelli, V., Croce, F.M.: Gall bladder emptying induced by a fatty meal: a reliable technique for a quantitative evaluation in humans of drugs inhibiting extravascular smooth muscle motility. Farmaco Ed. prat.27, 708–716 (1972 b)
Sacchetti, G., Mandelli, V., Roncoroni, L.: Farmacologia clinica del tratto gastrointestinale. Valutazione quantitativa dell'attività di farmeci inibenti la motilità. Boll. chim. farm.111, 100–107 (1972 a)
Sacchetti, G., Mandelli, V., Roncoroni, L., Montanari, C.: Influence of age and sex on gallbladder emptying induced by a fatty meal in normal subjects. Amer. J. Roentgenol.119, 40–45 (1973 a)
Sacchetti, G., Roncoroni, L., Mandelli, V.: Gall bladder emptying as a pharmacological test in humans. Farmaco Ed. prat.28, 324–329 (1973 b)
Ventafridda, V., Martino, G., Mandelli, V., Emanueli, A.: Indoprofen, a new analgesic and anti-inflammatory drug in cancer pain. Clin. Pharmacol. Ther.17, 284–289 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sacchetti, G., Roncoroni, L., Mandelli, V. et al. Effect of analgesic agents on emptying of the gallbladder in man. Eur J Clin Pharmacol 10, 127–131 (1976). https://doi.org/10.1007/BF00609471
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00609471