Summary
The detection of opiates and their metabolites in human hair has obtained an increasing importance in forensic toxicology, but many compounds [e.g. the heroin marker 6-monoacetylmorphine (MAM)] are regularly destroyed by the use of invasive extraction and hydrolysis procedures. This paper describes a method for the analysis of such sensible structures by means of guanidine/mercaptoethanol treatment, followed by specific solid phase extraction. The detection limit is better than 1 μg/g hair.
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Ahrens, B., Erdmann, F., Rochholz, G. et al. Detection of morphine and monoacetylmorphine (MAM) in human hair. Fresenius J Anal Chem 344, 559–560 (1992). https://doi.org/10.1007/BF00324655
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DOI: https://doi.org/10.1007/BF00324655