Summary
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1.
Chronic (10 mg/kg, i.p., once daily for 14 days) but not acute (10 mg/kg, i.p., 24 hr) administration of imipramine resulted in a decrease in both the responsiveness and the sensitivity of the contractions of the isolated rat vas deferens elicited by field stimulation to GABA and (−)-baclofen.
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In contrast, clonidine and isoproterenol effects were not altered by either treatment.
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This study shows for the first time that GABA action in the peripheral nervous system is altered by chronic treatment with antidepressants, possibly by inducing changes in a postreceptor element.
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Strobel, G.H., Calixto, J.B. & Ballejo, G. Decreasedγ-aminobutyric acid (GABA) modulatory effect on rat vas deferens neurotransmission after chronic administration of imipramine. Cell Mol Neurobiol 9, 469–473 (1989). https://doi.org/10.1007/BF00712794
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DOI: https://doi.org/10.1007/BF00712794