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Synthesis and some properties of the methyl ester and N,N-diethylamide of 2-azido-5-phenyl-4-thiazolecarboxylic acid

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The methyl ester and N,N-diethylamide of 2-azido-5-phenyl-4-thiazolecarboxylic acid were obtained by the reaction of the corresponding 4-substituted 2-hydrazino-5-phenylthiazole with NaNO2 in acid media. IR and UV spectroscopy were used to show that the compounds synthesized retain azide form in both the crystalline state and in solution. The reaction of azides with dicarbonyl compounds gave derivatives of 2-[5′-methyl-4′-acetyl-or 2-[5′-methyl-4′-ethoxycarbonyl-1′,2′,3′-triazol-1′-yl]-5-phenylthiazole-4-carboxylic acid.

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Science Center, Russian Academy of Sciences, 420083, Kazan

    V. A. Mamedov, V. N. Valeeva, L. A. Antokhina, G. M. Doroshkina, A. V. Chernova & I. A. Nuretdinov

Authors
  1. V. A. Mamedov
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  2. V. N. Valeeva
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  3. L. A. Antokhina
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  4. G. M. Doroshkina
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  5. A. V. Chernova
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  6. I. A. Nuretdinov
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 710–714, May, 1993.

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Mamedov, V.A., Valeeva, V.N., Antokhina, L.A. et al. Synthesis and some properties of the methyl ester and N,N-diethylamide of 2-azido-5-phenyl-4-thiazolecarboxylic acid. Chem Heterocycl Compd 29, 607–611 (1993). https://doi.org/10.1007/BF00534479

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  • DOI: https://doi.org/10.1007/BF00534479

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