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The effects of various agents in vitro on homocarnosine-carnosine synthetase from rat brain

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  • Chimica, Biochimica
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Summary

The present paper reports the first evidence that homocarnosine-carnosine synthetase from rat brain requires free sulfhydryl groups for activity. The activity of the synthetase can be stabilized by dithioerythritol and inhibited strongly by Cu2+, Cd2+, Hg2+, Zn2+, and to a lesser extent by Ca2+, Ni2+, Li, chlorpromazine, α-methyl DOPA and norepinephrine at the concentrations tested.

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Authors and Affiliations

  1. Department of Biochemistry, The University of South Dakota School of Medicine, 57069, Vermillion, South Dakota, USA

    R. H. Ng & F. D. Marshall

Authors
  1. R. H. Ng
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  2. F. D. Marshall
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Additional information

Acknowledgment. This work was supported by United States Public Health Service Grant No. NS-06137.

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Ng, R.H., Marshall, F.D. The effects of various agents in vitro on homocarnosine-carnosine synthetase from rat brain. Experientia 32, 839–841 (1976). https://doi.org/10.1007/BF02003717

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  • DOI: https://doi.org/10.1007/BF02003717

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