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Solacasine, a new steroidal alkaloid fromSolanum pseudocapsicum possessing antimicrobial activity

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Summary

Systematic fractionation of alcohol extracts ofSolanum pseudocapsicum. showed that solacasine is the main antibacterial constituent. Based on physiochemical studies, a structure is proposed.

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Author notes

  1. J. V. Juvarkar & J. L. Beal

    Present address: Division of Pharmacognosy, The Ohio State University, 43210, Columbus, Ohio, USA

Authors and Affiliations

  1. Department of Medicinal Chemistry, The University of Kansas, 66045, Lawrence, Kansas, USA

    L. A. Mitscher, J. V. Juvarkar & J. L. Beal

  2. Division of Pharmacognosy, The Ohio State University, 43210, Columbus, Ohio, USA

    L. A. Mitscher

Authors
  1. L. A. Mitscher
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  2. J. V. Juvarkar
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  3. J. L. Beal
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Additional information

The authors are grateful to Dr.R. Foltz, Battelle's Columbus Laboratories, and Mr.E. Fairchild of our laboratories for the mass spectral data, to Mr.Ruey-Ping Leu for the microbiological data, and to the NIH for grant No. AI-09846 in partial support of this work.

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Mitscher, L.A., Juvarkar, J.V. & Beal, J.L. Solacasine, a new steroidal alkaloid fromSolanum pseudocapsicum possessing antimicrobial activity. Experientia 32, 415–416 (1976). https://doi.org/10.1007/BF01920766

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