Summary
The interactions between Cp2TiCl2 and mononucleotides such as 5′-AMP, 5′-CMP, 5′-GMP and 5′-TMP were investigated by high-resolution 1H- and 31P-n.m.r. The results suggest that phosphate (O) and nucleobase (N) are all important targets of Cp2TiCl2. The mechanism of the Cp2TiCl2-DNA interaction is discussed.
Similar content being viewed by others
References
P. Koepf-Maier and H. Koepf, Chem. Rev., 87, 1137 (1987).
W. E. Berdel, H. J. Schmoll, M. E. Scheulen, A. Korfel, M. F. Knoche, A. Harstrick, F. Bach, J. Baumgart and G. Sass, J. Cancer Res. Clin. Oncol., 120, (Suppl.), R-172 (1994).
P. Koepf-Maier, W. Wagner and H. Koepf, Naturwis., 68, 272 (1981).
P. Koepf-Maier and H. Koepf, Naturwis., 67, 415 (1980).
H. Koepf and P. Koepf-Maier, ACS Symp. Ser., 209, 315 (1983).
B. Rosenberg, Cancer, 55, 2303 (1985).
J. H. Toney, C. P. Brock and T. J. Marks, J. Am. Chem. Soc., 108, 7263 (1986).
L. Y. Kuo, M. G. Kanatzidis, M. Sabat, A. L. Tipton and T. J. Marks, J. Am. Chem. Soc., 113, 9027 (1991).
J. H. Toney and T. J. Marks, J. Am. Chem. Soc., 107, 947 (1985).
J. M. Birmingham, Advan. Organometal. Chem., 2, 365 (1964).
M. L. McLaughlin, J. M. Cronan, Jr and R. D. Snelling, J. Am. Chem. Soc., 112, 8949 (1990).
S. Menzer, M. Sabat and B. Lippert, J. Am. Chem. Soc., 114, 4644 (1992).
D. B. Davies and S. S. Danyluk, Biochem., 13, 4417 (1974).
D. J. Wood, F. E. Hruska and K. K. Ogilvie, Can. J. Chem., 52, 3353 (1974).
D. B. Davies, Progress In NMR Spectrosc., 12, 135 (1978).
H. A. Tajmir-Riahi and T. Theophanides, Can. J. Chem., 61, 1813 (1983).
R. B. Martin, Acc. Chem. Res., 18, 32 (1985).
S. H. Kim and R. B. Martin, Inorg. Chim. Acta, 91, 19 (1984).
H. Iwahashi, H. Sugeta and Y. Kyogoku, Biochem., 21, 631 (1982).
J. D. Orbell, L. G. Marzilli and T. J. Kistenmacher, J. Am. Chem. Soc., 103, 5126 (1981).
M. D. Reily and L. G. Marzilli, J. Am. Chem. Soc., 108, 8299 (1986).
M. D. Reily, T. W. Hambly and L. G. Marzilli, J. Am. Chem. Soc., 110, 2999 (1988).
D. J. Nelson, P. L. Yeagle, T. L. Miller and R. B. Martin, Bioinorg. Chem., 5, 353 (1976).
M. P. Schweizer, A. D. Broom, P. O. P. Ts'o and D. P. Hollis, J. Am. Chem. Soc., 90, 1042 (1968).
G. Pneumatikakis, A. Yannopoulos and J. Markopoulos, Inorg. Chim. Acta, 151, 125 (1988).
S. L. Bruhn, J. H. Toney and G. J. Lippard, Prog. Inorg. Chem., 38, 477 (1990).
M. M. Harding, G. J. Harden and L. D. Field, FEBS Lett., 332, 291 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zhang, Z., Yang, P. & Guo, M. Study of interactions between titanocene dichloride and mononucleotides by high-resolution 1H- and 31P-nuclear magnetic resonance. Transition Met Chem 21, 322–326 (1996). https://doi.org/10.1007/BF00139027
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00139027