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Study of interactions between titanocene dichloride and mononucleotides by high-resolution 1H- and 31P-nuclear magnetic resonance

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The interactions between Cp2TiCl2 and mononucleotides such as 5′-AMP, 5′-CMP, 5′-GMP and 5′-TMP were investigated by high-resolution 1H- and 31P-n.m.r. The results suggest that phosphate (O) and nucleobase (N) are all important targets of Cp2TiCl2. The mechanism of the Cp2TiCl2-DNA interaction is discussed.

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References

  1. P. Koepf-Maier and H. Koepf, Chem. Rev., 87, 1137 (1987).

    Google Scholar 

  2. W. E. Berdel, H. J. Schmoll, M. E. Scheulen, A. Korfel, M. F. Knoche, A. Harstrick, F. Bach, J. Baumgart and G. Sass, J. Cancer Res. Clin. Oncol., 120, (Suppl.), R-172 (1994).

    Google Scholar 

  3. P. Koepf-Maier, W. Wagner and H. Koepf, Naturwis., 68, 272 (1981).

    Google Scholar 

  4. P. Koepf-Maier and H. Koepf, Naturwis., 67, 415 (1980).

    Google Scholar 

  5. H. Koepf and P. Koepf-Maier, ACS Symp. Ser., 209, 315 (1983).

    Google Scholar 

  6. B. Rosenberg, Cancer, 55, 2303 (1985).

    Google Scholar 

  7. J. H. Toney, C. P. Brock and T. J. Marks, J. Am. Chem. Soc., 108, 7263 (1986).

    Google Scholar 

  8. L. Y. Kuo, M. G. Kanatzidis, M. Sabat, A. L. Tipton and T. J. Marks, J. Am. Chem. Soc., 113, 9027 (1991).

    Google Scholar 

  9. J. H. Toney and T. J. Marks, J. Am. Chem. Soc., 107, 947 (1985).

    Google Scholar 

  10. J. M. Birmingham, Advan. Organometal. Chem., 2, 365 (1964).

    Google Scholar 

  11. M. L. McLaughlin, J. M. Cronan, Jr and R. D. Snelling, J. Am. Chem. Soc., 112, 8949 (1990).

    Google Scholar 

  12. S. Menzer, M. Sabat and B. Lippert, J. Am. Chem. Soc., 114, 4644 (1992).

    Google Scholar 

  13. D. B. Davies and S. S. Danyluk, Biochem., 13, 4417 (1974).

    Google Scholar 

  14. D. J. Wood, F. E. Hruska and K. K. Ogilvie, Can. J. Chem., 52, 3353 (1974).

    Google Scholar 

  15. D. B. Davies, Progress In NMR Spectrosc., 12, 135 (1978).

    Google Scholar 

  16. H. A. Tajmir-Riahi and T. Theophanides, Can. J. Chem., 61, 1813 (1983).

    Google Scholar 

  17. R. B. Martin, Acc. Chem. Res., 18, 32 (1985).

    Google Scholar 

  18. S. H. Kim and R. B. Martin, Inorg. Chim. Acta, 91, 19 (1984).

    Google Scholar 

  19. H. Iwahashi, H. Sugeta and Y. Kyogoku, Biochem., 21, 631 (1982).

    Google Scholar 

  20. J. D. Orbell, L. G. Marzilli and T. J. Kistenmacher, J. Am. Chem. Soc., 103, 5126 (1981).

    Google Scholar 

  21. M. D. Reily and L. G. Marzilli, J. Am. Chem. Soc., 108, 8299 (1986).

    Google Scholar 

  22. M. D. Reily, T. W. Hambly and L. G. Marzilli, J. Am. Chem. Soc., 110, 2999 (1988).

    Google Scholar 

  23. D. J. Nelson, P. L. Yeagle, T. L. Miller and R. B. Martin, Bioinorg. Chem., 5, 353 (1976).

    Google Scholar 

  24. M. P. Schweizer, A. D. Broom, P. O. P. Ts'o and D. P. Hollis, J. Am. Chem. Soc., 90, 1042 (1968).

    Google Scholar 

  25. G. Pneumatikakis, A. Yannopoulos and J. Markopoulos, Inorg. Chim. Acta, 151, 125 (1988).

    Google Scholar 

  26. S. L. Bruhn, J. H. Toney and G. J. Lippard, Prog. Inorg. Chem., 38, 477 (1990).

    Google Scholar 

  27. M. M. Harding, G. J. Harden and L. D. Field, FEBS Lett., 332, 291 (1993).

    Google Scholar 

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Zhang, Z., Yang, P. & Guo, M. Study of interactions between titanocene dichloride and mononucleotides by high-resolution 1H- and 31P-nuclear magnetic resonance. Transition Met Chem 21, 322–326 (1996). https://doi.org/10.1007/BF00139027

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  • DOI: https://doi.org/10.1007/BF00139027

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