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Inhibition ofSaccharomyces cerevisiae division by 5-trifluoro-methyl-6-azauracil

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Summary

Cell division, as studied in asynchronous cultures of yeast cells, is sensitive to 5-trifluoromethyl-6-azauracil (F3CAzU). Under defined conditions (10 mmoles l−1 F3CAzU) this compound blocks immediately and completely the process of cell division. Using synchronized cells, the time-point at which division process of yeast cell can be inhibited by F3CAzU has been determined. The inhibitor effect of this compound is completely reversed by thymine, thymidine and uracil.

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Authors and Affiliations

  1. Department of Fermentation Chemistry and Biongineering, Institute of Chemical Technology, 166 28, Prague 6

    V. Jirků, D. Petřiková & J. Škoda

  2. Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10, Prague 6, (Czechoslovakia)

    V. Jirků, D. Petřiková & J. Škoda

Authors
  1. V. Jirků
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  2. D. Petřiková
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  3. J. Škoda
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Jirků, V., Petřiková, D. & Škoda, J. Inhibition ofSaccharomyces cerevisiae division by 5-trifluoro-methyl-6-azauracil. Experientia 40, 1159–1161 (1984). https://doi.org/10.1007/BF01971472

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  • DOI: https://doi.org/10.1007/BF01971472

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