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Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease

  • Book
  • © 2023

Overview

Editors:
  1. Jörg Striessnig

    1. Center for Chemistry and Biomedicine, UI, Pharmacology and Toxicology, Innsbruck, Austria

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  • Provides state-of the art insight into current research on voltage-gared Ca2+ channels
  • Broadens the understanding of how Ca2+ channelopathies can provide novel insight into therapies of rare diseases
  • Discusses concepts of the regulation of Ca2+ channels by neurotransmitters, enzymes and drugs

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 279)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Modulation

    1. Front Matter

      Pages 1-1
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    2. CaV1.1 Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies

      • Marta Campiglio, Agnieszka Dyrda, Wietske E. Tuinte, Enikő Török
      Pages 3-39

    3. Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia

      • Miguel Martín-Aragón Baudel, Junyoung Hong, Johannes W. Hell, Madeline Nieves-Cintrón, Manuel F. Navedo
      Pages 41-58

    4. Sympathetic Nervous System Regulation of Cardiac Calcium Channels

      • Pedro J. del Rivero Morfin, Steven O. Marx, Manu Ben-Johny
      Pages 59-82

    5. Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19

      • Kelvin Wei Zhern Loh, Zhenyu Hu, Tuck Wah Soong
      Pages 83-103

  3. Pharmacological Approaches

    1. Front Matter

      Pages 105-105
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    2. The Role of Striatal Cav1.3 Calcium Channels in Therapeutics for Parkinson’s Disease

      • Margaret E. Caulfield, Fredric P. Manfredsson, Kathy Steece-Collier
      Pages 107-137

    3. Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors

      • Ariana C. Gavin, Henry M. Colecraft
      Pages 139-155

  4. Disease Insight from Channelopathies: Consequences for Pharmacology and Therapeutic Strategies

    1. Front Matter

      Pages 157-157
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    2. CACNA1C-Related Channelopathies

      • Kevin G. Herold, John W. Hussey, Ivy E. Dick
      Pages 159-181

    3. CACNA1D-Related Channelopathies: From Hypertension to Autism

      • Nadine J. Ortner
      Pages 183-225

    4. CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options

      • Elisabetta Indelicato, Sylvia Boesch
      Pages 227-248

    5. CaV3.2 (CACNA1H) in Primary Aldosteronism

      • Hoang An Dinh, Gabriel Stölting, Ute I. Scholl
      Pages 249-262

    6. CaV3.3 Channelopathies

      • Yousra El Ghaleb, Bernhard E. Flucher
      Pages 263-288

    7. Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits

      • Manuel Hessenberger, Sabrin Haddad, Gerald J. Obermair
      Pages 289-316
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Keywords

About this book

The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.

Editors and Affiliations

  • Center for Chemistry and Biomedicine, UI, Pharmacology and Toxicology, Innsbruck, Austria

    Jörg Striessnig

Bibliographic Information

  • Book Title: Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease

  • Editors: Jörg Striessnig

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-031-38437-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-38436-3Published: 01 August 2023

  • Softcover ISBN: 978-3-031-38439-4Due: 01 September 2023

  • eBook ISBN: 978-3-031-38437-0Published: 31 July 2023

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XII, 316

  • Number of Illustrations: 70 b/w illustrations, 30 illustrations in colour

  • Topics: Pharmacology/Toxicology, Human Genetics, Human Physiology

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