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The significance of MRI in myelin disorders

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Abstract

Systematic analysis of white matter changes on magnetic resonance (MR) images has increased the diagnostic quality of MR interpretation. For that purpose, structural elements were defined, relevant to the distinction of disease groups. Per disease group histograms were obtained of the frequency of involvement of these structural elements. On the reverse, this database could be used as the basis of an expert system. Loaded with the data of a new case, the program comes up with a differential diagnosis and probability percentage with confidence intervals per diagnostic item. The program has helped in identifying MR patterns in rare disorders.

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References

  1. Van der Knaap MS, Valk J, de Neeling N, Nauta JJP (1991) Pattern recognition in magnetic resonance imaging of white matter disorders in children and young adults.Neuroradiology 33 478–493.

    PubMed  Google Scholar 

  2. Valk J, van der Knaap MS (1989)Magnetic Resonance of Myelin, Myelination andMyelin Disorders. Berlin: Springer-Verlag.

    Google Scholar 

  3. Demaerel Ph, Wilms G, Verdru P, Carton H, Baert AL (1990) MR findings in globoid cell leucodystrophy.Neu-roradiology 32 520–522.

    Google Scholar 

  4. Morgan SH, Rudge P, Smith SJM, Bronstein AM, Kendall BE, Holly E, Young EP, Crawford M D'A, Bannister R (1990) The neurological complications of Anderson-Fabry disease: investigation of symptomatic and pre-symptomatic patients.Quart J Med 75 491–504.

    PubMed  Google Scholar 

  5. Brismar J, Brismar G, Coates R, Gascon G, Ozand P (1990) Increased density of the thalamus on CT scans in patients with GM2 gangliosidosis.AJNR 11 125–130.

    PubMed  Google Scholar 

  6. Dietemann JL, Filippi de la Palavesa MM, Tranchant C, Kastler B (1990) MR findings in mannosidosis.Neuroradiology 32 485–487.

    PubMed  Google Scholar 

  7. Shimoda-Matsubayashi S, Kuru Y, Sumie H, Ito T, Hattori N, Okuma Y, Mizuno Y (1990) MRI findings in the mild type of mucopolysaccharidosis II (Hunter's syndrome).Neuroradiology 32 328–330.

    PubMed  Google Scholar 

  8. Afifi AK, Sata Y, Waziri MH, Bell WE (1990) Computed tomography and magnetic resonance imaging of the brain in Hurler's disease.J Child Neurol 5 235–241.

    PubMed  Google Scholar 

  9. Van der Knaap MS, Valk J (1991) The MR spectrum of perioxisomal disorders.Neuroradiology 33 30–37.

    PubMed  Google Scholar 

  10. Van der Knaap MS, Valk J (1989) MR of aderenoleukodys-trophy: histopathologic correlations.AJNR 10 S12-S14.

    PubMed  Google Scholar 

  11. Sandhu PS, Dillon WP (1991) MR demonstration of leukoencephalopathy associated with mitochondral encephalomyopathy: case report.AJNR 12 375–379.

    PubMed  Google Scholar 

  12. Fujii T, Okuno T, Ito M, Mothoh K, Hamazaki S, Okada S, Kusaka H, Mikawa H (1990) CT, MRI, and autopsy findings in brain of a patient with MELAS.Pediatr Neurol 6 253–256.

    PubMed  Google Scholar 

  13. Yamagata T, Yano S, Okabe I, Miyao M, Momoi MY, Yanagisawa M, Hirata H, Komatsu K (1990) Ultrasonog-raphy and magnetic resonance imaging in Leigh disease.Pediatr Neurol 6 326–329.

    PubMed  Google Scholar 

  14. Brismar J, Brismar G, Gascon G, Ozand P (1990) Canavan disease: CT and MR imaging of the brain.AJNR 11 805–810.

    PubMed  Google Scholar 

  15. Hald JK, Nakstad PH, Skjeldal OH, Stromme P (1991) Bilateral arachnoid cysts of the temporal fossa in four children with glutaric aciduria type I.AJNR 12 407–409.

    PubMed  Google Scholar 

  16. Andreula CF, Blasi de R, Carella A (1991) CT and MR studies of methylmalonic acidemia.AJNR 12 410–412.

    PubMed  Google Scholar 

  17. Thompson AJ, Smith I, Brenton D, Youl BD, Rylance G, Davidson DC, Kendall B, Lees AJ (1990) Neurological deterioration in young adults with phenylketonuria.Lancet 336 602–605.

    PubMed  Google Scholar 

  18. Shaw DWW, Weinberger E, MaraviUa KR (1990) Cranial MR in phenylketonuria.J Comput Assist Tomogr 14 458–460.

    PubMed  Google Scholar 

  19. Pearsen KD, Gean-Marton AD, Levy HI, Davis KR (1990) Phenylketonuria: MR imaging of the brain with clinical correlation.Radiology 177 437–440.

    PubMed  Google Scholar 

  20. Shaw DWW, Maravilla KR, Weinberger E, Garretson J, Trahms CM, Scott CR (1991) MR imaging of phenylketonuria.AJNR 12 403–406.

    PubMed  Google Scholar 

  21. Sugita R, Takahashi S, Ishii K, Matsumoto K, Ishibashi T, Sakamoto, Narisawa K (1990) Brain CT and MR findings in hyperphenylalaninemia due to dihypdropeteridine reductase deficiency (variant of phenylketonuria).J Comput Assist Tomogr 14 669–703.

    Google Scholar 

  22. Brismar J, Aqeel A, Brismar G, Coates R, Gascon G, Ozand P (1990) Maple syrup urine disease: findings on CT and MR scans of the brain in 10 infants.AJNR 11 1219–1228.

    PubMed  Google Scholar 

  23. Press GA, Barshop BA, Haas RH, Nyhan WL, Glass RF, Hesselink JR (1989) Abnormalities of the brain in nonkeotic hyperglycinemia: MR manifestations.AJNR 10 315–321.

    PubMed  Google Scholar 

  24. Van der Knaap MS, Valk J (1989) The reflection of histology in MR imaging of Pelizaeus-Merzbacher disease.AJNR 10 99–103.

    PubMed  Google Scholar 

  25. Silverstein AM, Hirsh DK, Trobe JD, Gebarski SS (1990) MR imaging of the brain in five members of a family with Pelizaeus-Merzbacher disease.AJNR 11 495–499.

    PubMed  Google Scholar 

  26. Bobele GB, Garnica A, Bradley Schaefer G, Leonard JC, Wilson D, Marks WA, Leech RW, Brumback RA (1990) Neuroimaging findings in Alexander's disease.J Child Neurol 5 253–258.

    PubMed  Google Scholar 

  27. Hess DC, Fischer AQ, Yaghmai F, Figueroa R, Akamatsu Y (1990) Comparative neuroimaging with pathologic correlates in Alexander's disease.J Child Neurol 5 248–252.

    PubMed  Google Scholar 

  28. Shah M, Ross JS (1990) Infantile Alexander disease: MR appearance of a biopsy-proved case.AJNR 11 1105–1106.

    PubMed  Google Scholar 

  29. Naidu SB, Moser HW (1991) Value of neuroimaging in metabolic diseases affecting the CNS.AJNR 12 413–416.

    PubMed  Google Scholar 

  30. Sharief MK, Phil M, Thompson EJ (1991) The predictive value of intrathecal immunoglobulin synthesis and magnetic resonance imaging in acute isolated syndromes for subsequent development of multiple sclerosis.Ann Neurol 29 147–151.

    PubMed  Google Scholar 

  31. Harris JO, Frank JA, Patronas N, McFarlin DE, McFar-land HF (1991) Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: Implications for clinical trials and natural history.Ann Neurol 29 548–555.

    PubMed  Google Scholar 

  32. Zerrin Yetkin F, Haughton VM, Anne Papke R, Fischer ME, Rao SM (1991) Multiple sclerosis: Specificity of MR for diagnosis.Radiology 178 447–451.

    PubMed  Google Scholar 

  33. Truyen L, Gheuens J, Van de Vyver FL, Parizel PM, Peersman GV, Martin JJ (1990) Improved correlation of magnetic resonance imaging (MRI) with clinical status in multiple sclerosis (MS) by use of an extensive standardized imaging-protocol.J Neurol Sci 96 173–182.

    PubMed  Google Scholar 

  34. Quint DJ (1991) Multiple sclerosis and imaging of the corpus callosum.Radiology 180 15–17.

    PubMed  Google Scholar 

  35. Gean-Martin AD, Gilbert Vezina L, Marton KI, Stimac GK, Peyster RG, Taveras JM, Davis KR (1991) Abnormal corpus callosum: a sensitive and specific indicator of multiple sclerosis.Radiology 180 215–221.

    PubMed  Google Scholar 

  36. Paty DW, McFarlin DE, McDonald WI (1991) Magnetic resonance imaging and laboratory aids in the diagnosis of multiple sclerosis.Ann Neurol 29 3–5.

    PubMed  Google Scholar 

  37. Lynch SG, Rose JW, Smoker W, Petajan JH (1990) MRI in familial multiple sclerosis.Neurology 40 900–903.

    PubMed  Google Scholar 

  38. Millner MM, Ebner F, Justich E, Urban C (1990) Multiple sclerosis in childhood: contribution of serial MRI to earlier diagnosis.Dev Med Child Neurol 32 769–777.

    PubMed  Google Scholar 

  39. Osbom AG, Harnsberger HR, Smoker WRK, Boyer RS (1990) Multiple sclerosis in adolescents.AJNR 11 489–494.

    PubMed  Google Scholar 

  40. Ebner F, Millner MM, Justich E (1990) Multiple sclerosis in children: value of serial MR studies to monitor patients.AJNR 11 1023–1027.

    PubMed  Google Scholar 

  41. Shermann JL, Stern BJ (1990) Sarcoidosis of the CNS: comparisons of unenhanced and enhanced MR images.AJNR 11 915–923.

    PubMed  Google Scholar 

  42. Zuheir AL, Kawi M, Bohlega S, Banna M (1991) MRI findings in Neuro-Behget's disease.Neurology 41 405–408.

    PubMed  Google Scholar 

  43. Rafto SE, Milton WJ, Galetta SL, Grossman RI (1990) Biopsy-confirmed CNS Lyme disease: MR appearance at 1.5 T.AJNR 11 482–484.

    PubMed  Google Scholar 

  44. Loes DJ, Biller J, Yuh WTC, Hart MN, Godersky JC, Adams Jr HP, Keefauver SP, Tranel D (1990) Leukoen-cephalopathy in cerebral amyloid angiopathy: MR imaging in four case.AJNR 11 485–488.

    PubMed  Google Scholar 

  45. Hawke SHB, Hallinan JM, McLeod JG (1990) Cranial magnetic resonance imaging in chronic demyelinating polyneuropathy.J Neurol Neurosurg Psychiatry 53 794–796.

    PubMed  Google Scholar 

  46. Williams DW, Elster AD, Kramer SI (1990) Neurosarcoid-osis: gadolinium-enhanced MR imaging.J Comput Assist Tomogr 14 704–707.

    PubMed  Google Scholar 

  47. Fernandez RE, Rothberg M, Ferencz G, Wujack D (1990) Lyme disease of the CNS: MR imaging findings in 14 cases.AJNR 11 479–481.

    PubMed  Google Scholar 

  48. Doran M, Bydder GM (1990) Magnetic resonance perfusion and diffusion imaging.Neuroradiology 32 392–398.

    PubMed  Google Scholar 

  49. Doran M, Hajnal JV, Van Bruggen N, King MD, Young IR, Bydder GM (1990) Normal and abnormal white matter tracts shown by MR imaging using directional diffusion weighted sequences.J Comput Assist Tomogr 14 865–873.

    PubMed  Google Scholar 

  50. Hajnal JV, Doran M, Hall AS, Collins AG, Oatridge A, Pennock JM, Young IR, Bydder GM (1991) MR imaging of anisotropically restricted diffusion of water in the nervous system: technical, anatomic, and pathologic considerations.J Comput Assist Tomogr 15 1–18.

    PubMed  Google Scholar 

  51. Sakuma H, Nomura Y, Takeda K, Tagami T, Nakagawa T, Tamagawa Y, Ishii Y, Tsukamoto T (1991) Adult and neonatal human brain: diffusional anisotropy and myelination with diffusion-weighted MR imaging.Radiology 180 229–233.

    PubMed  Google Scholar 

  52. Miller DH, Austin SJ, Connelly A, Youl BD, Gadian DG, McDonald WI (1991) Proton magnetic resonance spectroscopy of an acute and chronic lesion in multiple sclerosis.Lancet 5 58–59.

    Google Scholar 

  53. Sappey-Marinier D (1990) High-resolution NMR spectroscopy of cerebral white matter in multiple sclerosis.Magn Reson Med 15 229–239.

    PubMed  Google Scholar 

  54. Chrysikopoulos HS, Press GA, Grafe MR, Hesselink JR, Wiley CA (1990) Encephalitis caused by human immunodeficiency virus: CT and MR imaging manifestations with clinical and pathologic correlation.Radiology 175 185–191.

    PubMed  Google Scholar 

  55. Grafe MR, Press GA, Berthoty DP, Hesselink JR, Wiley CA (1990) Abnormalities of the brain in AIDS patients: correlation of postmortem MR findings with neuropathology.AJNR 11 905–911.

    PubMed  Google Scholar 

  56. Kieburtz KD, Ketonen L, Zettelmaier AE, Kido D, Caine ED, Simon JH (1990) Magnetic resonance imaging findings in HIV cognitive impairment.Arch Neurol 47 643–645.

    PubMed  Google Scholar 

  57. Tien RD, Chu PK, Hesselink JR, Duberg A, Wley C (1991) Intracranial cryptococcosis in immunocompromised patients: CT and MR findings in 29 cases.AJNR 12 283–289.

    PubMed  Google Scholar 

  58. Menon DK, Baudouin CJ, Tomlinson D, Hoyle C (1990) Proton MR spectroscopy and imaging of the brain in AIDS: evidence of neuronal loss in regions that appear normal with imaging.J Comput Assist Tomogr 14 882–885.

    PubMed  Google Scholar 

  59. Barkovich AJ, Truwit CL (1990) Brain damage from perinatal asphyxia: Correlation of MR findings with gestational age.AJNR 11 1087–1096.

    PubMed  Google Scholar 

  60. Valk J, van der Knaap MS, Grauw de T, Taets v Amerongen AHM (1991) The role of imaging modalities in the diagnosis of posthypoxic-ischemic and hemorrhagic conditions of infants (part I or two).Klin Neuroradiol 1 72–79.

    Google Scholar 

  61. Byrne P, Welch R, Johnson MA, Darrah J, Piper M (1990) Serial magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy.J Pedwfr ll7 694–700.

    Google Scholar 

  62. Konishi Y, Kuriyama M, Hayakawa K, Konishi K, Yasu-jima M, Fujii Y, Sudo M (1990) Periventricular hyperin-tensity detected by magnetic resonance imaging in infancy.Pediatr Neurol 6 229–232.

    PubMed  Google Scholar 

  63. Feldman HM, Scher MS, Kemp SS (1990) Neurodevelop-mental outcome of children with evidence of periventricular leukomalacia on late MRI.Pediatr Neurol 6 296–302.

    PubMed  Google Scholar 

  64. Dietrich RB, Vining EP, Taira RK, Hall TR, Philipart M (1990) Myelin disorders of childhood: correlation of MR findings and severity of neurological impairment.J Comput Assist Tomogr 14 693–698.

    PubMed  Google Scholar 

  65. Leifer D, Buonanno PS, Richardson EP Jr (1990) Clinico-pathologic correlations of cranial magnetic resonance imaging of periventricular white matter.Neurology 40 911–918.

    PubMed  Google Scholar 

  66. Yamaguchi H, Fukuyama H, Harada K, Yamaguchi S, Moyoshi T, Doi T, Kumura J, Iwasaki Y, Asato R, Yonekura Y (1990) White matter hyperintensities may correspond to areas of increased blood volume: correlative MR and PET observations.J Comput Assist Tomogr 14 905–908.

    PubMed  Google Scholar 

  67. Bradley WG, Whitemore AR, Watanabe AS, Davis SJ, Teresi LM, Homyak M (1991) Association of deep white matter infarction with chronic communicating hydrocephalus: implications regarding the possible origin of normal-pressure hydrocephalus.AJNR 12 31–39.

    PubMed  Google Scholar 

  68. Hachinski V (1991) Binswanger's disease: neither Binswanger's nor a disease.J Neurol Sci 103 1.

    PubMed  Google Scholar 

  69. Gallucci M, Bozzao A, Splendiani A, Masciocchi C, Passariello R (1990) Wernicke encephalopathy: MR findings in five patients.AJNR 11 887–892.

    PubMed  Google Scholar 

  70. Victor M (1990) MR in the diagnosis of Wernicke—Korsakoff syndrome.AJNR 11 895–896.

    Google Scholar 

  71. Donnal JF, Ralph Heinz E, Burger PC (1990) MR of reversible thalamic lesions in Wernicke syndrome.AJNR 11 893–894.

    PubMed  Google Scholar 

  72. Koci TM, Chiang F, Chow P, Wang A, Chiu LC, Itabshi H, Mehringer CM (1990) Thalamic extrapontine lesions in central pontine myelinolysis.AJNR 11 1229–1233.

    PubMed  Google Scholar 

  73. Prayer L, Wimberger D, Kramer J, Grimm G, Oder W, Imhof H (1990) Cranial MRI in Wilson's disease.Neurora-diology 32 211–214.

    Google Scholar 

  74. Chamuleau RAFM, Bosman DK (1991) What the clinician can learn from MR glutamine/glutamate assays.NMR Biomed 4 103–108.

    PubMed  Google Scholar 

  75. Ross BD (1991) Biochemical considerations in 1H spectroscopy. Glutamate and glutamine; myo-inositol and related metabolites.NMR Biomed 4 59–63.

    PubMed  Google Scholar 

  76. Kreis R, Farrow N, Ross BD (1991) Localized 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols.NMR Biomed 4 109–116.

    PubMed  Google Scholar 

  77. Valk PE, Dillon WP (1991) Radiation injury of the brain.AJNR 12 45–62.

    PubMed  Google Scholar 

  78. Wilson DA, Nitschke R, Bowman ME, Chaffin MJ, Sex-auer CL, Prince JR (1991) Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: correlation with neuropsy-chologic deficiencies.Radiology 180 205–209.

    PubMed  Google Scholar 

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  1. Department of Child Neurology Free University Hospital, Amsterdam, The Netherlands

    M. S. van der Knaap

  2. Department of Diagnostic Radiology, Free University Hospital, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands

    J. Valk

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Valk, J., van der Knaap, M.S. The significance of MRI in myelin disorders. MAGMA 2, 191–201 (1994). https://doi.org/10.1007/BF01705240

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