Abstract
Quantitative proton spectroscopy was performed on 26 volunteers and 9 patients using STEAM. Voxels (8 ml) were localized within white matter or meningioma and water-suppressed spectra acquired with TR=2 s at three echo times. Concentrations were calculated using individual relaxation parameter values with tissue water as an internal reference. Compared to white matter, meningiomas were characterized by an increased choline/creatine ratio, the absence ofN-acetylasparate, and the presence of alanine. Further, theT 2 of choline and its concentration were both significantly greater in meningiomas than white matter (p<0.01). Thus, the high choline/creatine ratio seen in meningioma spectra is the consequence of a greater concentration and a longerT 2. The longerT 2 may reflect differences in the relative proportions of choline-containing compounds. Our data demonstrate that individual measurements of relaxation parameters are important for long echo spectra and may reveal important metabolic information.
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Manton, D.J., Lowry, M., Blackband, S.J. et al. Quantitative proton MRS of brain tumors reveals increased cholineT 2 in meningiomas. MAGMA 2, 361–363 (1994). https://doi.org/10.1007/BF01705272
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DOI: https://doi.org/10.1007/BF01705272