Concentrated by condensates

Distinct chemical environments in biomolecular condensates

  • Henry R. Kilgore
  • Peter G. Mikhael
  • Richard A. Young
Article

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  • Drops of dew condensing on leaves

    This themed issue presents a collection of Reviews, Perspectives and Articles that aim to reveal the molecular and chemical principles underlying phase-separated condensate formation and promote the development and use of new tools for the study of phase separation biology.

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  • A proteomics and computational approach was developed to map the proximal proteome of the activated μ-opioid receptor and to extract subcellular location, trafficking and functional partners of G-protein-coupled receptor activity.

    • Benjamin J. Polacco
    • Braden T. Lobingier
    • Ruth Hüttenhain
    Article
  • Huang et al. developed E3-substrate tagging by ubiquitin biotinylation (E-STUB), a proximity labeling-based method for direct identification of ubiquitylated substrates for a given E3 ligase, providing a useful tool for substrate discovery of targeted protein degradation and the understanding of E3 ligase function.

    • Hai-Tsang Huang
    • Ryan J. Lumpkin
    • William R. Sellers
    Article
  • Hypoxia induces ·NO-dependent hydrogen sulfide (H2S) biogenesis by inhibiting the transsulfuration pathway. H2S oxidation promotes endothelial cell proliferation to support neovascularization in tissue injury and tumor xenograft models.

    • Roshan Kumar
    • Victor Vitvitsky
    • Ruma Banerjee
    Article
    • Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with predicting potential pathways of resistance. A new analytical method for evaluating chemogenetic profiles reveals contributions from death-regulatory genes.

      • Jesse D. Gelles
      • Jerry Edward Chipuk
      News & Views
    • BURP-domain proteins belong to an emerging class of autocatalytic copper-containing proteins that modify themselves after synthesis. Now, a report explains how their structure and metal coordination sphere control the installation of crosslinks within the core peptide, and shows how nature leverages mechanistic paradigms to create diversity.

      • Ninian J. Blackburn
      News & Views
    • An integrative approach has now enabled elucidation of the complete biosynthetic pathway of a prominent saponin adjuvant. Reconstruction of the whole biosynthetic pathway in a heterologous host provides new perspectives for the biotechnological supply of this immunostimulant.

      • Vincent Courdavault
      • Nicolas Papon
      News & Views
    • Reprogramming of the genetic code allows the synthesis of proteins using new building blocks, thus opening the door to the development of a wider variety of medicines and biocatalysts; however, it is currently limited to α-amino acids. A new study has now reported the incorporation of β-linked and α,α-disubstituted monomers into a ribosome-synthesized protein.

      • Ya-Ming Hou
      • Yuko Nakano
      News & Views
    • The rate of ATP production and the total mass of enzymes were quantified for both glycolysis and mitochondrial respiration to determine the proteome efficiency of these pathways. Per unit of enzyme mass, mitochondrial respiration generates energy faster than glycolysis and is thus more proteome efficient. Despite being less proteome efficient, constitutive glycolysis comes with the benefit of rendering cells robust to hypoxia.

      Research Briefing

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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